Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for ilvA (threonine deaminase) in L-isoleucine biosynthesis

Or see other characterized proteins similar to ilvA

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of ilvA

Curated proteins or TIGRFams with EC 4.3.1.19
Ignore hits to items matching threonine deaminase when looking for 'other' hits
Curated sequence B1N2N4: L-serine ammonia-lyase (EC 4.3.1.17)
Ignore hits to P09367 when looking for 'other' hits (L-serine ammonia-lyase (EC 4.3.1.17))
Comment: (Ignore some CharProtDB annotations with threonine deaminase but no EC). B1N2N4 is included because it is active on both serine and threonine (PMID:19931317). P09367 is ignored because it may be active on threonine as well as serine.

Fetched 23 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 22 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 329-436 amino acids (not heteromeric)

TSAL_GEOSL / Q74FW6 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine/serine ammonia-lyase; EC 4.3.1.19; EC 4.3.1.17 from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Q74FW6 threonine ammonia-lyase (EC 4.3.1.19) from Geobacter sulfurreducens
PFams: PALP
402 amino acids: PaperBLAST, CDD, Compare to cluster

A0QX60 threonine ammonia-lyase (EC 4.3.1.19) from Mycolicibacterium smegmatis
PFams: PALP, Thr_dehydrat_C
430 amino acids: PaperBLAST, CDD, Compare to cluster

B1N2N4 L-serine ammonia-lyase (EC 4.3.1.17) from Entamoeba histolytica
PFams: PALP
423 amino acids: PaperBLAST, CDD, Compare to cluster

Q04513 threonine ammonia-lyase (EC 4.3.1.19) from Corynebacterium glutamicum
PFams: PALP, Thr_dehydrat_C
436 amino acids: PaperBLAST, CDD, Compare to cluster

Q2V0H1 serine racemase (EC 5.1.1.18) (from HMM only) from Pyrobaculum islandicum
PFams: PALP, ACT
402 amino acids: PaperBLAST, CDD, Compare to cluster

Q96GA7 Serine dehydratase-like (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens
SDSL_HUMAN / Q96GA7 Serine dehydratase-like; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; Serine dehydratase 2; SDH 2; EC 4.3.1.19; EC 4.3.1.17 from Homo sapiens (Human)
Q96GA7 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens
PFams: PALP
329 amino acids: PaperBLAST, CDD, Compare to cluster

b3117 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655
P0AGF6 catabolic threonine dehydratase (EC 4.3.1.17; EC 4.3.1.19) from Escherichia coli (strain K12)
TDCB_ECOLI / P0AGF6 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Escherichia coli (strain K12)
RF|NP_417587 threonine ammonia-lyase; EC 4.3.1.19 from Escherichia coli K12
PFams: PALP
329 amino acids: PaperBLAST, CDD, Compare to cluster

TDCB_SALTY / P11954 L-threonine dehydratase catabolic TdcB; L-serine dehydratase; Threonine deaminase; EC 4.3.1.19; EC 4.3.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: PALP
329 amino acids: PaperBLAST, CDD, Compare to cluster

SDSL_MOUSE / Q8R238 Serine dehydratase-like; L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH; SDH; EC 4.3.1.17; EC 4.3.1.19 from Mus musculus (Mouse)
PFams: PALP
329 amino acids: PaperBLAST, CDD, Compare to cluster

TSAL_THEMA / Q9WYJ1 L-threonine ammonia-lyase; L-serine ammonia-lyase; Threonine dehydratase; EC 4.3.1.19; EC 4.3.1.17 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: PALP, ACT
401 amino acids: PaperBLAST, CDD, Compare to cluster

CCNA_03750 threonine deaminase (EC 4.3.1.19) from Caulobacter crescentus NA1000
PFams: PALP, ACT_4, ACT
400 amino acids: PaperBLAST, CDD, Compare to cluster

Ga0059261_3694 threonine deaminase (EC 4.3.1.19) from Sphingomonas koreensis DSMZ 15582
PFams: PALP, ACT_4
420 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS15860 threonine deaminase (EC 4.3.1.19) from Pedobacter sp. GW460-11-11-14-LB5
PFams: PALP, Thr_dehydrat_C
416 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 514-606 amino acids (not heteromeric)

b3772 threonine deaminase (EC 4.3.1.19) from Escherichia coli K-12 substr. MG1655
P04968 threonine deaminase (EC 4.3.1.19) from Escherichia coli (strain K12)
ILVA_ECOLI / P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12)
P04968 threonine ammonia-lyase (EC 4.3.1.19) from Escherichia coli
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
514 amino acids: PaperBLAST, CDD, Compare to cluster

V6QU65 threonine ammonia-lyase (EC 4.3.1.19) from Fusarium graminearum
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
581 amino acids: PaperBLAST, CDD, Compare to cluster

TD1_SOLLC / A0FKE6 Threonine dehydratase 1 biosynthetic, chloroplastic; SlTD1; Threonine deaminase 1; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
606 amino acids: PaperBLAST, CDD, Compare to cluster

THDH_SCHPO / O94634 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
600 amino acids: PaperBLAST, CDD, Compare to cluster

THDH_YEAST / P00927 Threonine dehydratase, mitochondrial; Threonine deaminase; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
576 amino acids: PaperBLAST, CDD, Compare to cluster

TD2_SOLLC / P25306 Threonine dehydratase 2 biosynthetic, chloroplastic; SlTD2; Threonine deaminase 2; EC 4.3.1.17; EC 4.3.1.19 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
595 amino acids: PaperBLAST, CDD, Compare to cluster

TD_NICAT / Q9AXU4 Threonine dehydratase; Threonine deaminase; EC 4.3.1.19 from Nicotiana attenuata (Coyote tobacco)
Q9AXU4 threonine ammonia-lyase (EC 4.3.1.19) from Nicotiana attenuata
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
601 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 328-360 amino acids (not heteromeric)

P20132 L-serine dehydratase (EC 4.3.1.19; EC 4.3.1.17) from Homo sapiens
SDHL_HUMAN / P20132 L-serine dehydratase/L-threonine deaminase; SDH; L-serine deaminase; L-threonine dehydratase; TDH; EC 4.3.1.17; EC 4.3.1.19 from Homo sapiens (Human)
P20132 L-serine ammonia-lyase (EC 4.3.1.17) from Homo sapiens
PFams: PALP
328 amino acids: PaperBLAST, CDD, Compare to cluster

STDH_YEAST / P25379 Catabolic L-serine/threonine dehydratase; EC 4.3.1.17; EC 4.3.1.19 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PALP
360 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

TD_SOLTU / P31212 Threonine dehydratase biosynthetic, chloroplastic; Threonine deaminase; EC 4.3.1.19 from Solanum tuberosum (Potato)
PFams: PALP, Thr_dehydrat_C, Thr_dehydrat_C
359 amino acids: PaperBLAST, CDD