Clusters of Characterized Proteins

Clustering the characterized proteins for ilvI (acetolactate/acetohydroxybutanoate synthase catalytic subunit) in L-isoleucine biosynthesis

Or see other characterized proteins similar to ilvI

Or see all steps for L-isoleucine biosynthesis

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Definition of ilvI

• HMM TIGR00118
• Curated proteins matching acetohydroxy-acid synthase%large
• Curated proteins matching acetohydroxy acid synthase%large
• Curated proteins matching acetohydroxybutanoate synthase, catalytic subunit
• Curated proteins matching acetohydroxybutanoate synthase, catalytic subunit
• Curated proteins matching acetohydroxyacid synthase subunit B
• Ignore hits to items matching EC 2.2.1.6 when looking for 'other' hits
• Ignore hits to CH_124219 when looking for 'other' hits (threonine deaminase [Arxula adeninivorans])
• Ignore hits to O53554 when looking for 'other' hits (acetolactate synthase (EC 2.2.1.6). Putative acetolactate synthase large subunit IlvX; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6)
• Comment: ilvIH (or ilvGM) is a two-subunit enzyme that forms acetolactate or acetohydroxybutanoate. (S)-2-aceto-2-hydroxybutanoate synthesis is part of isoleucine biosynthesis. Acetolactate synthesis is part of valine or leucine biosynthesis. CH_124129 is probably correct but has limited data and vaguer annotations. IlvX from Mycobacterium tuberculosis (O53554) is ignored because, although annotated with this activity by both SwissProt and BRENDA, we could not find experimental evidence, and it is reported to lack activity (PMID:20884690).

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 548-618 amino acids (4/5 heteromeric)

b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655
P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 574 amino acids: PaperBLAST, CDD, Compare to cluster

ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 618 amino acids: PaperBLAST, CDD, Compare to cluster

ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12)
GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
548 amino acids: PaperBLAST, CDD, Compare to cluster

O08353 acetohydroxy-acid synthase large subunit (EC 2.2.1.6) from Methanococcus aeolicus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 599 amino acids: PaperBLAST, CDD, Compare to cluster

Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 585 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (2/2 heteromeric)

ILVB2_MYCTU / O06335 Putative acetolactate synthase large subunit IlvB2; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
O06335 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 552 amino acids: PaperBLAST, CDD

ILVG_MYCTU / P9WG39 Acetolactate synthase large subunit IlvG; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WG39 acetolactate synthase (EC 2.2.1.6) from Mycobacterium tuberculosis
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 547 amino acids: PaperBLAST, CDD