Clusters of Characterized Proteins

Clustering the characterized proteins for acdH ((2S)-2-methylbutanoyl-CoA dehydrogenase) in L-isoleucine catabolism

Or see other characterized proteins similar to acdH

Or see all steps for L-isoleucine catabolism

Or cluster curated proteins matching a keyword

Definition of acdH

• Curated proteins or TIGRFams with EC 1.3.8.5
• Curated sequence PfGW456L13_2983: Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1)
• Curated sequence 7025618: Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12)
• Curated sequence MONOMER-17424: short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1)
• Ignore hits to GFF2392 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.1))
• Ignore hits to GFF2713 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.5))
• Ignore hits to PfGW456L13_2985 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.5))
• Ignore hits to AO353_25670 when looking for 'other' hits (isobutyryl-CoA dehydrogenase (EC 1.3.8.5))
• Ignore hits to P45857 when looking for 'other' hits (Acyl-CoA dehydrogenase; EC 1.3.99.-)
• Ignore hits to CH_091788 when looking for 'other' hits (acyl-CoA dehydrogenase)
• Comment: EC 1.3.8.5 includes (2S)-2-methylbutanoyl-CoA dehydrogenases and also isobutyryl-CoA dehydrogenases (involved in valine degradation) or sometimes 3-methylbutanoyl-CoA dehydrogenases (involved in leucine degradation, usually given EC 1.3.8.4). Some enzymes act on all three methylacyl-CoA substrates. Other genes are required only for valine degradation and their activity on 2-methylbutanoyl-CoA uncertain, so they are marked ignore. PfGW456L13_2983 and Shewana3_2769 (VIMSS 7025618) and PP_2216 (MONOMER-17424) were annotated with other EC numbers (implying other acyl-CoA substrates) but are involved in isoleucine utilization, so are included. Various isobutyryl-CoA dehydrogenases are ignored (they may well act on 2-methylbutanoyl-CoA as well). P45857 (mmgC from B. subtilis) is part of an operon with methylcitrate cycle genes, and could be involved in isoleucine catabolism, but its biochemical activity is uncertain, so it is ignored, as is the nearly-identical CH_091788.

Fetched 14 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 14 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 375-432 amino acids (not heteromeric)

ACDSB_HUMAN / P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
432 amino acids: PaperBLAST, CDD, Compare to cluster

P70584 2-methyl branched chain acyl-CoA dehydrogenase subunit (EC 1.3.8.5) from Rattus norvegicus
ACDSB_RAT / P70584 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Rattus norvegicus (Rat)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
432 amino acids: PaperBLAST, CDD, Compare to cluster

Q9XCG5 acyl-CoA dehydrogenase subunit (EC 1.3.8.4; EC 1.3.8.5) from Streptomyces avermitilis
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
386 amino acids: PaperBLAST, CDD, Compare to cluster

Q88KS3 short-chain acyl-CoA dehydrogenase monomer (EC 1.3.8.1) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster

Shewana3_2769 Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) from Shewanella sp. ANA-3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
385 amino acids: PaperBLAST, CDD, Compare to cluster

SO1679 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Shewanella oneidensis MR-1
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
385 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_13850 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas simiae WCS417
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_2996 2-methyl-branched-chain-enoyl-CoA reductase (EC 1.3.8.5) from Acidovorax sp. GW101-3H11
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
376 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_2445 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas stutzeri RCH2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
379 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_2983 Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1) from Pseudomonas fluorescens GW456-L13
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_4787 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N1B4
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_25680 2-methylbutanoyl-CoA dehydrogenase / butanoyl-CoA dehydrogenase / isobutyryl-CoA dehydrogenase (EC 1.3.8.1; EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_26355 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2C3
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_1146 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) from Pseudomonas fluorescens FW300-N2E2
PFams: Acyl-CoA_dh_N, Acyl-CoA_dh_M, Acyl-CoA_dh_1, Acyl-CoA_dh_2
375 amino acids: PaperBLAST, CDD, Compare to cluster