Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for epi (methylmalonyl-CoA epimerase) in L-isoleucine catabolism

Or see other characterized proteins similar to epi

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Or cluster curated proteins matching a keyword

Definition of epi

Curated proteins or TIGRFams with EC 5.1.99.1
Ignore hits to 3607309 when looking for 'other' hits (Methylmalonyl-CoA epimerase (EC 5.1.99.1))
Comment: In the fitness browser reannotations, Dshi_0724 from Dinoroseobacter shibae (Dino:3607309) was annotated as the epimerase because it was annotated as such by SEED and it has a specific phenotype on propionate, which seemed to confirm its annotation. But Dshi_0724 belongs to the uncharacterized family DUF4174 / PF13778 and has a signal peptide. Also, D. shibae contains another, apparently essential, epi (Dshi_2630).

Fetched 9 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 1 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 134-176 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A4YEG2 methylmalonyl-CoA epimerase monomer (EC 5.1.99.1) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YEG2 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Metallosphaera sedula
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4
140 amino acids: PaperBLAST, CDD, Compare to cluster

K7SKA8 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Acidipropionibacterium acidipropionici
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4
153 amino acids: PaperBLAST, CDD, Compare to cluster

Q96PE7 methylmalonyl CoA epimerase (EC 5.1.99.1) from Homo sapiens
MCEE_HUMAN / Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Homo sapiens (Human)
Q96PE7 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Homo sapiens
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4
176 amino acids: PaperBLAST, CDD, Compare to cluster

MCE_PYRHO / O58010 Methylmalonyl-CoA epimerase; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4
136 amino acids: PaperBLAST, CDD, Compare to cluster

EPI_RHOS4 / Q3IZP4 Ethylmalonyl-CoA/methylmalonyl-CoA epimerase; EC 5.1.99.-; EC 5.1.99.1 from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4, Glyoxalase_6
134 amino acids: PaperBLAST, CDD, Compare to cluster

Q8VQN0 methylmalonyl CoA epimerase subunit (EC 5.1.99.1) from Propionibacterium freudenreichii subsp. shermanii
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4
148 amino acids: PaperBLAST, CDD, Compare to cluster

A9WGS0 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
PFams: Glyoxalase, Glyoxalase_3, Glyoxalase_4
139 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

Q8RCQ6 methylmalonyl-CoA epimerase (EC 5.1.99.1) from Caldanaerobacter subterraneus subsp. tengcongensis
PFams: Glyoxalase_4, Glyoxalase
150 amino acids: PaperBLAST, CDD

Dsui_0512 Methylmalonyl-CoA epimerase (EC 5.1.99.1) from Dechlorosoma suillum PS
PFams: Glyoxalase_4
158 amino acids: PaperBLAST, CDD