Clusters of Characterized Proteins

Clustering the characterized proteins for livM (L-isoleucine ABC transporter, permease component 2 (LivM/BraE)) in L-isoleucine catabolism

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Definition of livM

• Curated sequence P22729: High-affinity branched-chain amino acid transport system permease protein LivM; LIV-I protein M. LivM aka B3456, component of Leucine; leucine/isoleucine/valine porter. branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2). branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2)
• Curated sequence P21628: High-affinity branched-chain amino acid transport system permease protein BraE, component of Branched chain amino acid uptake transporter. Transports alanine
• Curated sequence Q8DQH9: ABC transporter membrane-spanning permease-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM
• UniProt sequence Q1MCU1: SubName: Full=Transmembrane component of a broad range amino acid ABC transporter {ECO:0000313|EMBL:CAK09239.1};
• UniProt sequence A0A165KER0: SubName: Full=ABC transporter ATP-binding protein {ECO:0000313|EMBL:KZT15410.1};
• UniProt sequence A0A159ZYE0: SubName: Full=High-affinity branched-chain amino acid ABC transporter permease LivM {ECO:0000313|EMBL:AMZ72284.1};
• Comment: LivM from Streptococcus pneumoniae lacks an N-terminal domain of unknown function (DUF3382) that is found in E.coli and P. aeruginosa

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 318-425 amino acids (3/5 heteromeric)

A0A165KER0 ABC transporter ATP-binding protein
358 amino acids: PaperBLAST, CDD, Compare to cluster

b3456 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2) from Escherichia coli K-12 substr. MG1655
P22729 branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM (EC 7.4.2.2) from Escherichia coli (strain K12)
LIVM_ECOLI / P22729 High-affinity branched-chain amino acid transport system permease protein LivM; LIV-I protein M from Escherichia coli (strain K12)
TC 3.A.1.4.1 / P22729 LivM aka B3456, component of Leucine; leucine/isoleucine/valine porter from Escherichia coli
PFams: DUF3382, BPD_transp_2
Heteromeric, 425 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.4.8 / P21628 High-affinity branched-chain amino acid transport system permease protein BraE, component of Branched chain amino acid uptake transporter. Transports alanine from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: DUF3382, BPD_transp_2
Heteromeric, 417 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.4.10 / Q8DQH9 ABC transporter membrane-spanning permease-branched chain amino acid transport, component of The branched chain hydrophobic amino acid transporter, LivJFGHM from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
PFams: BPD_transp_2
Heteromeric, 318 amino acids: PaperBLAST, CDD, Compare to cluster

A0A159ZYE0 High-affinity branched-chain amino acid ABC transporter permease LivM
418 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q1MCU1 Transmembrane component of a broad range amino acid ABC transporter
463 amino acids: PaperBLAST, CDD