Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for MFS-glucose (glucose transporter, MFS superfamily) in lactose catabolism

Or see other characterized proteins similar to MFS-glucose

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Definition of MFS-glucose

Curated sequence A0A0H2VG78: Glucose transporter GlcP; Glucose/H(+) symporter
Curated sequence CH_091029: galactose transporter. Galactose, glucose uniporter, Gal2. Also transports xylose
Curated sequence CH_091305: solute carrier family 2, facilitated glucose transporter member 8. The blastocyst/testis glucose transporter, Glut8 (Doege et al., 2000) (insulin stimulated in blastocysts)
Curated sequence CH_091400: low-affinity glucose transporter HXT4. Low-affinity glucose transporter HXT4; Low-affinity glucose transporter LGT1. Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1; Rag1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9)
Curated sequence CH_091463: sugar transport protein 13. The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death
Curated sequence CH_091493: sugar transport protein 6. Sugar transport protein 6; Hexose transporter 6. High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose.
Curated sequence CH_091695: sugar transport protein 1. Sugar transport protein 1; Glucose transporter; Hexose transporter 1. The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. Km=20 uM for glucose)
Curated sequence CH_122958: high affinity glucose transporter
Curated sequence CH_124310: high-affinity glucose transporter ght2
Curated sequence A0A1D8PCL1: High-affinity glucose transporter 1
Curated sequence F1R0H0: Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10
Curated sequence O44616: Facilitated glucose transporter homolog
Curated sequence O44827: Facilitated glucose transporter protein 1
Curated sequence P0AEP1: Galactose-proton symporter; Galactose transporter. Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977. ; galactose:H⁺ symporter. galactose:H⁺ symporter. galactose:H+ symporter (galP)
Curated sequence P11166: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter. The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier
Curated sequence P11167: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1
Curated sequence P11168: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2. Glucosamine/glucose uniporter, Glut-2; it may also transport dehydroascorbate (Mardones et al., 2011;
Curated sequence P11169: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3. Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3 or GLUT3). It mediates the facilitative uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose
Curated sequence P12336: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2
Curated sequence P14142: Solute carrier family 2, facilitated glucose transporter member 4; GT2; Glucose transporter type 4, insulin-responsive; GLUT-4
Curated sequence P14246: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2
Curated sequence P14672: Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4. Insulin-responsive facilitative glucose transporter in skeletal and cardiac muscle, adipose, and other tissues, Glut4 (GTR4; SLC2A4; 509aas). Defects in Glut4 cause noninsulin-dependent diabetes mellitus (NIDDM)
Curated sequence P17809: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1
Curated sequence P19357: Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4
Curated sequence P27674: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1
Curated sequence P32037: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3
Curated sequence P47843: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3
Curated sequence P58353: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence P58354: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
Curated sequence Q07647: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3. Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b)
Curated sequence Q56ZZ7: Plastidic glucose transporter 4; AtpGlcT. Plastidic glucose transporter 4 (AtpGlcT). glucose transporter
Curated sequence Q9JIF3: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
Curated sequence Q9JJZ1: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
Curated sequence Q9NY64: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1. Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)
Curated sequence Q9WV38: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence Q9XSC2: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3
Curated sequence A0QZX3: Glucose permease GlcP (Pimentel-Schmitt et al., 2008) (most similar to 2.A.1.1.32)
Curated sequence A0ZXK6: The monosaccharide (MST) (glucose > mannose > galactose > fructose):H+ symporter, MST1
Curated sequence A1Z264: Sugar & polyol transporter 1 (SPT1): broad specificity; takes up glucose (Schilling and Oesterhelt, 2007). Loss of the first 3 TMSs of the 12 TMSs does not prevent sugar uptake or sugar recognition but lowers substrate affinity & transport rate, and abolished H+ symport
Curated sequence G4N740: Glucose transporter Rco-3 or MoST1. MoST1 plays a specific role in conidiation and mycelial melanization which is not shared by other hexose transporter family members in M. oryzae
Curated sequence H9BPB6: The sea bream facilitative glucose transporter 1 (GLUT1)
Curated sequence P15729: Glucose/fructose:H+ symporter, GlcP
Curated sequence P23585: High-affinity glucose transporter HXT2
Curated sequence P49374: The high affinity glucose transporter, Hgt1
Curated sequence Q0SE66: The glucose uptake porter, GluP
Curated sequence Q2MDH1: Glucose/xylose facilitator-1, GXF1 (functions by sugar uniport; low affinity
Curated sequence Q2MEV7: Glucose/xylose: H+ symporter, Gsx1
Curated sequence Q63ZP5: Glucose transporter 1, GLUT1 or Slc2A1 of 491 aas and 12 TMSs
Curated sequence Q7BEC4: The major glucose (or 2-deoxyglucose) uptake transporter, GlcP
Curated sequence Q8G3X1: The D-glucose:H+ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose)
Curated sequence Q8J0U9: Low affinity glucose:H+ symporter, MstC
Curated sequence Q8NTX0: Myo-Inositol uptake porter, IolT1 (Km=0.2mM)
Curated sequence Q9LT15: The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4
Curated sequence O07563: Glucose/mannose transporter GlcP; Glucose/mannose:H(+) symporter. Glucose/Mannose/Xylose: H+ symporter (Paulsen et al., 1998; G.Gosset, personal communication)
Curated sequence Q8TDB8: Solute carrier family 2, facilitated glucose transporter member 14; Glucose transporter type 14; GLUT-14. Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)
Curated sequence CH_091552: glucose transporter 9b. The embryonic liver, kidney, and other tissue uric acid (urate) transporter, Glut9 (SLC2A9) (Wright et al. 2010). Mutations in this transporter cause severe renal hyperuricemia
Curated sequence CH_121984: low affinity glucose transporter MstE. The low affinity, glucose-inducible glucose transporter, MstE
Curated sequence P22732: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5. Fructose uniporter, GLUT5
Curated sequence P43427: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence P46408: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
Curated sequence Q3T9X0: Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter
Curated sequence Q6PXP3: Solute carrier family 2, facilitated glucose transporter member 7; Glucose transporter type 7; GLUT-7; hGLUT7. The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport
Curated sequence Q9BYW1: Solute carrier family 2, facilitated glucose transporter member 11; Glucose transporter type 11; GLUT-11. The hexose (glucose and fructose but not galactose) transporter (Glut11; SLC2A11)
Curated sequence Q9NRM0: Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter
Curated sequence Q26579: The glucose transport protein, GTP1
Curated sequence A3M0N3: The Glucose Transporter/Sensor Rgt2
Curated sequence CH_091058: high-affinity glucose transporter ght2. Hexose:H+ symporter, Ght2 (Glucose > Fructose)
Curated sequence CH_123257: potential high affinity glucose transporter
Curated sequence B8MYS7: MFS glucose transporter mfs1; Asparasone A synthesis protein mfs1
Curated sequence P32465: Low-affinity glucose transporter HXT1. Low-affinity glucose transporter HXT1
Curated sequence P32466: Low-affinity glucose transporter HXT3
Curated sequence Q9P3U6: High-affinity glucose transporter Ght1 (Hexose transporter 1)
Curated sequence O95528: Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10. The glucose transporter, GLUT10, was originally believed to be responsible for Type 2 diabetes. It is now believed to be responsible for arterial tortuosity, a rare autosomal recessive connective tissue disease (Callewaert et al., 2007). GLUT10 transports glucose and 2-deoxy glucose (Km=0.3 mM), and is inhibited by galactose and phloretin
Curated sequence Q5J316: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12
Curated sequence Q6NWF1: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12
Curated sequence Q8BFW9: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12
Curated sequence Q8TD20: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12. solute carrier family 2, member 12, Glut12 of 617 aas and 12 TMSs
Curated sequence B1PLM1: Hexose (glucose) transporter, GT4 (D2) (almost identical to 2.A.1.1.16)
Curated sequence O61059: The D-glucose/D-ribose transporter, LmGT2 (Most similar to 1.A.1.1.18)
Curated sequence O61060: The glucose transporter, LmGT3 (homologous to LmGT2 (1.A.1.1.75)). Two threonine residues located in the hydrophilic loops connecting TMSs 3 & 4 and 7 & 8 of GT3 prevent transport of D-ribose. Changing these two residues to alanine (as in GT2) allows transport of ribose. Thus, loops 3-4 and 7-8 partially determine substrate specificity
Curated sequence O76486: Glucose transporter, GT1. GT1, 2, and 3 are homologues. GT2 and GT3 transport ribose as well as glucose at different rates. GT3 transports ribose with 6-fold lower efficiency due to two threonines in GT3 that are alanines in GT2. They are in two loops between TMSs 3, 4, and 7, 8 (Naula et al., 2010). GT1 is expressed in the flagellar membrane and may be both a glucose transporter and sensor, allowing the parasites to enter the stationary phase when they deplete glucose although in the absence of the sensor, they lose viability
Curated sequence Q06222: Glucose/mannose/fructose transporter and high affinity sensor, Snf3p (regulates glucose transport via other systems)
Curated sequence A5Y0C3: Facilitative (Na+-independent) glucose-specific transporter (Km = 3 mM) of 486 aas and 12 TMSs, HT1; inhibited by cytochalasin B and localized to the midgut
Curated sequence Q3UDF0: Solute carrier family 2, facilitated glucose transporter member 6; Glucose transporter type 6; GLUT-6
Curated sequence Q9UGQ3: Solute carrier family 2, facilitated glucose transporter member 6; Glucose transporter type 6; GLUT-6. solute carrier family 2 (facilitated glucose transporter), member 6
Curated sequence O25788: The Na+-dependent sugar transporter, HP1174 (transports glucose, galactose, mannose and 2-deoxyglucose (Psakis et al. 2009)). (most similar to 2.A.1.7.2; 49% identity)
Curated sequence P0C105: Glucose/galactose porter
Curated sequence Q04DP6: The glucose transporter, OEOE_1574; does not transport fructose
Curated sequence Q04FN1: Glucose transporter, OEOE_0819. Does not transport fructose
Curated sequence CH_091224: D-xylose-proton symporter-like 1. Vacuolar (tonoplast) glucose transporter1, Vgt1 (important for seed germination and flowering)
Curated sequence CH_091141: sodium-dependent glucose transporter 1. Sodium-dependent glucose transporter 1; rNaGLT1; Major facilitator superfamily domain-containing protein 4B. Rat kidney Na+-dependent glucose (methyl α-glucoside) transporter, NaGLT1 (glucose:Na+:Na+=1:1)
Curated sequence P21906: Glucose facilitated diffusion protein. Glucose uniporter
Curated sequence Q8IRI6: Glucose transporter type 1
Curated sequence C5DX43: The fructose/glucose uniporter, Ffz2 (64% identical to 2.A.1.2.23)
Curated sequence P39004: High-affinity hexose transporter HXT7. High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6/Hxt7). Asn331 and hydrophobic residue side chains in TMS5 determine substrate affinity
Curated sequence CH_091031: high-affinity hexose transporter HXT6
Ignore hits to CH_091031 when looking for 'other' hits (high-affinity hexose transporter HXT6)
Curated sequence P43581: hexose transporter HXT10. Hexose uniporter
Ignore hits to CH_122303 when looking for 'other' hits (high-affinity hexose transporter)
Ignore hits to P40886 when looking for 'other' hits (Hexose transporter HXT8)
Ignore hits to P54862 when looking for 'other' hits (Hexose transporter HXT11 (Low-affinity glucose transporter LGT3))
Ignore hits to Q9P3U7 when looking for 'other' hits (Probable high-affinity hexose transporter ght8, mitochondrial; Hexose transporter 8)
Ignore hits to C5E4Z7 when looking for 'other' hits (The fructose-specific uniporter, Ffz1 (69% identical to Ffz2)
Ignore hits to CH_123252 when looking for 'other' hits (potential hexose transporter)
Ignore hits to CH_123250 when looking for 'other' hits (potential hexose transporter)
Ignore hits to CH_122864 when looking for 'other' hits (potential sugar sensor or transporter)
Ignore hits to P39924 when looking for 'other' hits (Hexose transporter HXT13)
Ignore hits to CH_124796 when looking for 'other' hits (hexose transporter Ght4)
Ignore hits to P54854 when looking for 'other' hits (Hexose transporter HXT15)
UniProt sequence A0KXM0: SubName: Full=Glucose/galactose transporter {ECO:0000313|EMBL:ABK48539.1};
Comment: MFS superfamily glucose transporters include: glcP, O07563 (glcP from B. subtilis), SLCA14/Q8TDB8, ght/rgt, SLC2A10, GT4, GTR6, gluP, and singletons Q04DP6 Q04FN1 CH_091224 CH_091141 P21906 Q8IRI6 C5DX43. Also add the hexose transporters HXT7_YEAST / P39004, CharProtDB::CH_091031 (nearly identical). Ignore CharProtDB::CH_091031 which is nearly identical to G4N740. Add P43581, yet another yeast glucose transporter. Ignore CH_122303, yet another hexose transporter. Ignore yet more yeast hexose transporters P40886, P54862, GHT8_SCHPO / Q9P3U7, C5E4Z7, CH_123252, CH_123250, CH_122864, P39924, CH_124796, P54854. Shewana3_2310 = glcP(Mal) = A0KXM0 was shown to be a glucose transporter (PMID:20836887).

Fetched 97 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 91 of these sequences

Found 7 clusters of similar sequences. Another 8 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 446-583 amino acids (not heteromeric)

GLCP_STAES / A0A0H2VG78 Glucose transporter GlcP; Glucose/H(+) symporter from Staphylococcus epidermidis (strain ATCC 12228)
PFams: Sugar_tr, MFS_1, TRI12, MFS_1
446 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.6 / P13181 Galactose, glucose uniporter, Gal2. Also transports xylose from Saccharomyces cerevisiae (Baker's yeast)
GI|1360445 galactose transporter from Saccharomyces cerevisiae
PFams: Sugar_tr, MFS_1
574 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.46 / Q9JIF3 The blastocyst/testis glucose transporter, Glut8 (Doege et al., 2000) (insulin stimulated in blastocysts) from Mus musculus (Mouse)
CH_091305 solute carrier family 2, facilitated glucose transporter member 8 from Mus musculus
PFams: Sugar_tr, MFS_1
477 amino acids: PaperBLAST, CDD, Compare to cluster

HXT4_YEAST / P32467 Low-affinity glucose transporter HXT4; Low-affinity glucose transporter LGT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.1.1.30 / P32467 Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1; Rag1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9) from Saccharomyces cerevisiae (Baker's yeast)
CH_091400 low-affinity glucose transporter HXT4 from Saccharomyces cerevisiae
PFams: Sugar_tr, MFS_1
576 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.50 / Q94AZ2 The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_198006.1 sugar transport protein 13 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
526 amino acids: PaperBLAST, CDD, Compare to cluster

STP6_ARATH / Q9SFG0 Sugar transport protein 6; Hexose transporter 6 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.56 / Q9SFG0 High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_187247.1 sugar transport protein 6 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
507 amino acids: PaperBLAST, CDD, Compare to cluster

STP1_ARATH / P23586 Sugar transport protein 1; Glucose transporter; Hexose transporter 1 from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.60 / P23586 The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. Km=20 uM for glucose) from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_172592.1 sugar transport protein 1 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
522 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122958 high affinity glucose transporter from Candida albicans
PFams: Sugar_tr, MFS_1
545 amino acids: PaperBLAST, CDD, Compare to cluster

CH_124310 high-affinity glucose transporter ght2 from Magnaporthe grisea 70-15
PFams: Sugar_tr, MFS_1
570 amino acids: PaperBLAST, CDD, Compare to cluster

HGT1_CANAL / A0A1D8PCL1 High-affinity glucose transporter 1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: Sugar_tr, MFS_1
545 amino acids: PaperBLAST, CDD, Compare to cluster

GTR10_DANRE / F1R0H0 Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10 from Danio rerio (Zebrafish) (Brachydanio rerio)
PFams: Sugar_tr, MFS_1, TRI12, MFS_1, Sugar_tr
513 amino acids: PaperBLAST, CDD, Compare to cluster

FGTH1_CAEEL / O44616 Facilitated glucose transporter homolog from Caenorhabditis elegans
PFams: Sugar_tr, MFS_1
516 amino acids: PaperBLAST, CDD, Compare to cluster

FGT1_CAEEL / O44827 Facilitated glucose transporter protein 1 from Caenorhabditis elegans
PFams: Sugar_tr, MFS_1
510 amino acids: PaperBLAST, CDD, Compare to cluster

b2943 galactose:H+ symporter (galP) from Escherichia coli BW25113
b2943 galactose:H⁺ symporter from Escherichia coli K-12 substr. MG1655
P0AEP1 galactose:H⁺ symporter from Escherichia coli (strain K12)
GALP_ECOLI / P0AEP1 Galactose-proton symporter; Galactose transporter from Escherichia coli (strain K12)
TC 2.A.1.1.1 / P0AEP1 Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977; from Escherichia coli (strain K12)
PFams: TRI12, Sugar_tr, MFS_1, MFS_2, MFS_1
464 amino acids: PaperBLAST, CDD, Compare to cluster

GTR1_HUMAN / P11166 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter from Homo sapiens (Human)
TC 2.A.1.1.28 / P11166 The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, Compare to cluster

GTR1_RAT / P11167 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, Compare to cluster

GTR2_HUMAN / P11168 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Homo sapiens (Human)
TC 2.A.1.1.29 / P11168 Glucosamine/glucose uniporter, Glut-2; it may also transport dehydroascorbate (Mardones et al., 2011; from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
524 amino acids: PaperBLAST, CDD, Compare to cluster

GTR3_HUMAN / P11169 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Homo sapiens (Human)
TC 2.A.1.1.91 / P11169 Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3 or GLUT3). It mediates the facilitative uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose from Homo sapiens
PFams: Sugar_tr, MFS_1
496 amino acids: PaperBLAST, CDD, Compare to cluster

GTR2_RAT / P12336 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1, Folate_carrier
522 amino acids: PaperBLAST, CDD, Compare to cluster

GLUT4_MOUSE / P14142 Solute carrier family 2, facilitated glucose transporter member 4; GT2; Glucose transporter type 4, insulin-responsive; GLUT-4 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, Compare to cluster

GTR2_MOUSE / P14246 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1, Folate_carrier
523 amino acids: PaperBLAST, CDD, Compare to cluster

GLUT4_HUMAN / P14672 Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4 from Homo sapiens (Human)
TC 2.A.1.1.80 / P14672 Insulin-responsive facilitative glucose transporter in skeletal and cardiac muscle, adipose, and other tissues, Glut4 (GTR4; SLC2A4; 509aas). Defects in Glut4 cause noninsulin-dependent diabetes mellitus (NIDDM) from Homo sapiens
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, Compare to cluster

GTR1_MOUSE / P17809 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, Compare to cluster

GLUT4_RAT / P19357 Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
509 amino acids: PaperBLAST, CDD, Compare to cluster

GTR1_BOVIN / P27674 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1 from Bos taurus (Bovine)
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, Compare to cluster

GTR3_MOUSE / P32037 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
493 amino acids: PaperBLAST, CDD, Compare to cluster

HXT7_YEAST / P39004 High-affinity hexose transporter HXT7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.1.1.31 / P39004 High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6/Hxt7). Asn331 and hydrophobic residue side chains in TMS5 determine substrate affinity from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: Sugar_tr, MFS_1
570 amino acids: PaperBLAST, CDD, Compare to cluster

GTR3_SHEEP / P47843 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Ovis aries (Sheep)
PFams: Sugar_tr, MFS_1
494 amino acids: PaperBLAST, CDD, Compare to cluster

GTR5_BOVIN / P58353 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Bos taurus (Bovine)
PFams: Sugar_tr, MFS_1
501 amino acids: PaperBLAST, CDD, Compare to cluster

GTR8_BOVIN / P58354 Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1 from Bos taurus (Bovine)
PFams: Sugar_tr, MFS_1
478 amino acids: PaperBLAST, CDD, Compare to cluster

GTR3_RAT / Q07647 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Rattus norvegicus (Rat)
TC 2.A.1.1.12 / Q07647 Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b) from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
493 amino acids: PaperBLAST, CDD, Compare to cluster

Q56ZZ7 glucose transporter from Arabidopsis thaliana
PLST4_ARATH / Q56ZZ7 Plastidic glucose transporter 4; AtpGlcT from Arabidopsis thaliana (Mouse-ear cress)
TC 2.A.1.1.102 / Q56ZZ7 Plastidic glucose transporter 4 (AtpGlcT) from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
546 amino acids: PaperBLAST, CDD, Compare to cluster

GTR8_MOUSE / Q9JIF3 Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
477 amino acids: PaperBLAST, CDD, Compare to cluster

GTR8_RAT / Q9JJZ1 Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1 from Rattus norvegicus (Rat)
PFams: Sugar_tr, MFS_1
478 amino acids: PaperBLAST, CDD, Compare to cluster

GTR8_HUMAN / Q9NY64 Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1 from Homo sapiens (Human)
TC 2.A.1.1.89 / Q9NY64 Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1) from Homo sapiens
PFams: Sugar_tr, MFS_1
477 amino acids: PaperBLAST, CDD, Compare to cluster

GTR5_MOUSE / Q9WV38 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
501 amino acids: PaperBLAST, CDD, Compare to cluster

GTR3_RABIT / Q9XSC2 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Oryctolagus cuniculus (Rabbit)
PFams: Sugar_tr, MFS_1
494 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.65 / A0QZX3 Glucose permease GlcP (Pimentel-Schmitt et al., 2008) (most similar to 2.A.1.1.32) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
PFams: Sugar_tr, MFS_1
498 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.43 / A0ZXK6 The monosaccharide (MST) (glucose > mannose > galactose > fructose):H+ symporter, MST1 from Geosiphon pyriformis
PFams: Sugar_tr, MFS_1
540 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.69 / A1Z264 Sugar & polyol transporter 1 (SPT1): broad specificity; takes up glucose (Schilling and Oesterhelt, 2007). Loss of the first 3 TMSs of the 12 TMSs does not prevent sugar uptake or sugar recognition but lowers substrate affinity & transport rate, and abolished H+ symport from Galdieria sulphuraria
PFams: Sugar_tr, MFS_1
557 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.117 / G4N740 Glucose transporter Rco-3 or MoST1. MoST1 plays a specific role in conidiation and mycelial melanization which is not shared by other hexose transporter family members in M. oryzae from Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
PFams: Sugar_tr, MFS_1
547 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.86 / H9BPB6 The sea bream facilitative glucose transporter 1 (GLUT1) from Sparus aurata
PFams: Sugar_tr, MFS_1
492 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.32 / P15729 Glucose/fructose:H+ symporter, GlcP
PFams: Sugar_tr, MFS_1
468 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.111 / P23585 High-affinity glucose transporter HXT2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: Sugar_tr, MFS_1
541 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.39 / P49374 The high affinity glucose transporter, Hgt1 from Kluyveromyces lactis (Yeast) (Candida sphaerica)
PFams: Sugar_tr, MFS_1
551 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.81 / Q0SE66 The glucose uptake porter, GluP from Rhodococcus sp. (strain RHA1)
PFams: Sugar_tr, MFS_1
483 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.67 / Q2MDH1 Glucose/xylose facilitator-1, GXF1 (functions by sugar uniport; low affinity from Candida intermedia
PFams: Sugar_tr, MFS_1
547 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.51 / Q2MEV7 Glucose/xylose: H+ symporter, Gsx1 from Candida intermedia
PFams: Sugar_tr, MFS_1
522 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.130 / Q63ZP5 Glucose transporter 1, GLUT1 or Slc2A1 of 491 aas and 12 TMSs from Xenopus laevis
PFams: Sugar_tr, MFS_1
491 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.35 / Q7BEC4 The major glucose (or 2-deoxyglucose) uptake transporter, GlcP from Streptomyces lividans
PFams: Sugar_tr, MFS_1
472 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.42 / Q8G3X1 The D-glucose:H+ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose) from Bifidobacterium longum
PFams: Sugar_tr, MFS_1, TRI12
517 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.58 / Q8J0U9 Low affinity glucose:H+ symporter, MstC from Aspergillus niger
PFams: Sugar_tr, MFS_1
583 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.53 / Q8NTX0 Myo-Inositol uptake porter, IolT1 (Km=0.2mM) from Corynebacterium glutamicum (Brevibacterium flavum)
PFams: Sugar_tr, MFS_1, MFS_1
491 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.124 / Q9LT15 The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4 from Arabidopsis thaliana
PFams: MFS_1, Sugar_tr
514 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 486-562 amino acids (not heteromeric)

GTR14_HUMAN / Q8TDB8 Solute carrier family 2, facilitated glucose transporter member 14; Glucose transporter type 14; GLUT-14 from Homo sapiens (Human)
TC 2.A.1.1.90 / Q8TDB8 Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14) from Homo sapiens
PFams: Sugar_tr, MFS_1
520 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.5 / P43581 Hexose uniporter from Saccharomyces cerevisiae (Baker's yeast)
RF|NP_116644.1 hexose transporter HXT10 from Saccharomyces cerevisiae
PFams: Sugar_tr, MFS_1
546 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.47 / Q5ERC7 The embryonic liver, kidney, and other tissue uric acid (urate) transporter, Glut9 (SLC2A9) (Wright et al. 2010). Mutations in this transporter cause severe renal hyperuricemia from Mus musculus (Mouse)
RF|NP_001012363.2 glucose transporter 9b from Mus musculus
PFams: Sugar_tr, MFS_1
523 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.36 / Q400D8 The low affinity, glucose-inducible glucose transporter, MstE from Emericella nidulans (Aspergillus nidulans)
CH_121984 low affinity glucose transporter MstE from Emericella nidulans
PFams: Sugar_tr, MFS_1
562 amino acids: PaperBLAST, CDD, Compare to cluster

GTR5_HUMAN / P22732 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Homo sapiens (Human)
TC 2.A.1.1.13 / P22732 Fructose uniporter, GLUT5
PFams: Sugar_tr, MFS_1
501 amino acids: PaperBLAST, CDD, Compare to cluster

GTR5_RAT / P43427 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Rattus norvegicus (Rat)
PFams: MFS_1, Sugar_tr
502 amino acids: PaperBLAST, CDD, Compare to cluster

GTR5_RABIT / P46408 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Oryctolagus cuniculus (Rabbit)
PFams: Sugar_tr, MFS_1
486 amino acids: PaperBLAST, CDD, Compare to cluster

GTR9_MOUSE / Q3T9X0 Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1, MFS_1
538 amino acids: PaperBLAST, CDD, Compare to cluster

GTR7_HUMAN / Q6PXP3 Solute carrier family 2, facilitated glucose transporter member 7; Glucose transporter type 7; GLUT-7; hGLUT7 from Homo sapiens (Human)
TC 2.A.1.1.37 / Q6PXP3 The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
512 amino acids: PaperBLAST, CDD, Compare to cluster

GTR11_HUMAN / Q9BYW1 Solute carrier family 2, facilitated glucose transporter member 11; Glucose transporter type 11; GLUT-11 from Homo sapiens (Human)
TC 2.A.1.1.44 / Q9BYW1 The hexose (glucose and fructose but not galactose) transporter (Glut11; SLC2A11) from Homo sapiens
PFams: Sugar_tr, MFS_1
496 amino acids: PaperBLAST, CDD, Compare to cluster

GTR9_HUMAN / Q9NRM0 Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1
540 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.52 / Q26579 The glucose transport protein, GTP1 from Schistosoma mansoni (Blood fluke)
PFams: Sugar_tr, MFS_1
521 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 528-570 amino acids (not heteromeric)

TC 2.A.1.1.68 / A3M0N3 The Glucose Transporter/Sensor Rgt2 from Pichia stipitis
PFams: Sugar_tr, MFS_1
528 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.21 / O74969 Hexose:H+ symporter, Ght2 (Glucose > Fructose) from Schizosaccharomyces pombe (Fission yeast)
RF|NP_596425.1 high-affinity glucose transporter ght2 from Schizosaccharomyces pombe
PFams: Sugar_tr, MFS_1
531 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123257 potential high affinity glucose transporter from Candida albicans
PFams: Sugar_tr, MFS_1
545 amino acids: PaperBLAST, CDD, Compare to cluster

MF127_ASPFN / B8MYS7 MFS glucose transporter mfs1; Asparasone A synthesis protein mfs1 from Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
PFams: Sugar_tr, MFS_1
529 amino acids: PaperBLAST, CDD, Compare to cluster

HXT1_YEAST / P32465 Low-affinity glucose transporter HXT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
TC 2.A.1.1.108 / P32465 Low-affinity glucose transporter HXT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: Sugar_tr, MFS_1
570 amino acids: PaperBLAST, CDD, Compare to cluster

HXT3_YEAST / P32466 Low-affinity glucose transporter HXT3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Sugar_tr, MFS_1
567 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.112 / Q9P3U6 High-affinity glucose transporter Ght1 (Hexose transporter 1) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
PFams: Sugar_tr, MFS_1
557 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 541-622 amino acids (not heteromeric)

GTR10_HUMAN / O95528 Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10 from Homo sapiens (Human)
TC 2.A.1.1.59 / O95528 The glucose transporter, GLUT10, was originally believed to be responsible for Type 2 diabetes. It is now believed to be responsible for arterial tortuosity, a rare autosomal recessive connective tissue disease (Callewaert et al., 2007). GLUT10 transports glucose and 2-deoxy glucose (Km=0.3 mM), and is inhibited by galactose and phloretin from Homo sapiens (Human)
PFams: Sugar_tr, MFS_1, Sugar_tr
541 amino acids: PaperBLAST, CDD, Compare to cluster

GTR12_BOVIN / Q5J316 Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12 from Bos taurus (Bovine)
PFams: Sugar_tr, MFS_1, Sugar_tr
621 amino acids: PaperBLAST, CDD, Compare to cluster

GTR12_DANRE / Q6NWF1 Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12 from Danio rerio (Zebrafish) (Brachydanio rerio)
PFams: Sugar_tr, MFS_1, Sugar_tr
610 amino acids: PaperBLAST, CDD, Compare to cluster

GTR12_MOUSE / Q8BFW9 Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1, Sugar_tr
622 amino acids: PaperBLAST, CDD, Compare to cluster

GTR12_HUMAN / Q8TD20 Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12 from Homo sapiens (Human)
TC 2.A.1.1.87 / Q8TD20 solute carrier family 2, member 12, Glut12 of 617 aas and 12 TMSs from Homo sapiens
PFams: Sugar_tr, MFS_1, Sugar_tr
617 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 529-627 amino acids (not heteromeric)

TC 2.A.1.1.71 / B1PLM1 Hexose (glucose) transporter, GT4 (D2) (almost identical to 2.A.1.1.16) from Leishmania mexicana
PFams: Sugar_tr, MFS_1
627 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.77 / O61059 The D-glucose/D-ribose transporter, LmGT2 (Most similar to 1.A.1.1.18) from Leishmania mexicana
PFams: Sugar_tr, MFS_1, Sugar_tr
567 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.78 / O61060 The glucose transporter, LmGT3 (homologous to LmGT2 (1.A.1.1.75)). Two threonine residues located in the hydrophilic loops connecting TMSs 3 & 4 and 7 & 8 of GT3 prevent transport of D-ribose. Changing these two residues to alanine (as in GT2) allows transport of ribose. Thus, loops 3-4 and 7-8 partially determine substrate specificity from Leishmania mexicana
PFams: Sugar_tr, MFS_1, Sugar_tr
566 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.76 / O76486 Glucose transporter, GT1. GT1, 2, and 3 are homologues. GT2 and GT3 transport ribose as well as glucose at different rates. GT3 transports ribose with 6-fold lower efficiency due to two threonines in GT3 that are alanines in GT2. They are in two loops between TMSs 3, 4, and 7, 8 (Naula et al., 2010). GT1 is expressed in the flagellar membrane and may be both a glucose transporter and sensor, allowing the parasites to enter the stationary phase when they deplete glucose although in the absence of the sensor, they lose viability from Leishmania mexicana
PFams: Sugar_tr, MFS_1, Sugar_tr
610 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.1.18 / Q06222 Glucose/mannose/fructose transporter and high affinity sensor, Snf3p (regulates glucose transport via other systems) from Trypanosoma brucei brucei
PFams: Sugar_tr, MFS_1
529 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 6 407-423 amino acids (not heteromeric)

TC 2.A.1.7.7 / O25788 The Na+-dependent sugar transporter, HP1174 (transports glucose, galactose, mannose and 2-deoxyglucose (Psakis et al. 2009)). (most similar to 2.A.1.7.2; 49% identity) from Helicobacter pylori
PFams: MFS_1
407 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.1.7.2 / P0C105 Glucose/galactose porter from Brucella abortus
PFams: MFS_1
412 amino acids: PaperBLAST, CDD, Compare to cluster

A0KXM0 Glucose/galactose transporter
423 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 7 486-507 amino acids (not heteromeric)

TC 2.A.1.1.128 / A5Y0C3 Facilitative (Na+-independent) glucose-specific transporter (Km = 3 mM) of 486 aas and 12 TMSs, HT1; inhibited by cytochalasin B and localized to the midgut from Nilaparvata lugens
PFams: Sugar_tr, MFS_1
486 amino acids: PaperBLAST, CDD, Compare to cluster

GTR6_MOUSE / Q3UDF0 Solute carrier family 2, facilitated glucose transporter member 6; Glucose transporter type 6; GLUT-6 from Mus musculus (Mouse)
PFams: Sugar_tr, MFS_1
497 amino acids: PaperBLAST, CDD, Compare to cluster

GTR6_HUMAN / Q9UGQ3 Solute carrier family 2, facilitated glucose transporter member 6; Glucose transporter type 6; GLUT-6 from Homo sapiens (Human)
TC 2.A.1.1.88 / Q9UGQ3 solute carrier family 2 (facilitated glucose transporter), member 6 from Homo sapiens
PFams: MFS_1, Sugar_tr
507 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/8 heteromeric)

MFS4B_RAT / Q80T22 Sodium-dependent glucose transporter 1; rNaGLT1; Major facilitator superfamily domain-containing protein 4B from Rattus norvegicus (Rat)
TC 2.A.1.7.4 / Q80T22 Rat kidney Na+-dependent glucose (methyl α-glucoside) transporter, NaGLT1 (glucose:Na+:Na+=1:1) from Rattus norvegicus (Rat)
RF|NP_788269.1 sodium-dependent glucose transporter 1 from Rattus norvegicus
PFams: MFS_1
484 amino acids: PaperBLAST, CDD

TC 2.A.1.1.45 / Q8L6Z8 Vacuolar (tonoplast) glucose transporter1, Vgt1 (important for seed germination and flowering) from Arabidopsis thaliana (Mouse-ear cress)
RF|NP_186959.2 D-xylose-proton symporter-like 1 from Arabidopsis thaliana
PFams: Sugar_tr, MFS_1
503 amino acids: PaperBLAST, CDD
(similar to SwissProt::P11168 from Cluster 1, but similarity to seed sequence is below thresholds)

GLCP_BACSU / O07563 Glucose/mannose transporter GlcP; Glucose/mannose:H(+) symporter from Bacillus subtilis (strain 168)
TC 2.A.1.7.3 / O07563 Glucose/Mannose/Xylose: H+ symporter (Paulsen et al., 1998; G.Gosset, personal communication) from Bacillus subtilis
PFams: MFS_1
401 amino acids: PaperBLAST, CDD

GLF_ZYMMO / P21906 Glucose facilitated diffusion protein from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
TC 2.A.1.1.4 / P21906 Glucose uniporter from Zymomonas mobilis
PFams: Sugar_tr, MFS_1
473 amino acids: PaperBLAST, CDD
(similar to CharProtDB::CH_091305 from Cluster 1, but similarity to seed sequence is below thresholds)

GTR1_DROME / Q8IRI6 Glucose transporter type 1 from Drosophila melanogaster (Fruit fly)
PFams: Sugar_tr, MFS_1
1440 amino acids: PaperBLAST, CDD

TC 2.A.1.2.46 / C5DX43 The fructose/glucose uniporter, Ffz2 (64% identical to 2.A.1.2.23) from Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)
PFams: MFS_1
601 amino acids: PaperBLAST, CDD

TC 2.A.1.68.1 / Q04DP6 The glucose transporter, OEOE_1574; does not transport fructose from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: MFS_2, MFS_1
403 amino acids: PaperBLAST, CDD

TC 2.A.1.17.2 / Q04FN1 Glucose transporter, OEOE_0819. Does not transport fructose from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: MFS_1
395 amino acids: PaperBLAST, CDD