Clusters of Characterized Proteins

Clustering the characterized proteins for galK (galactokinase (-1-phosphate forming)) in lactose catabolism

Or see other characterized proteins similar to galK

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Definition of galK

• Curated proteins or TIGRFams with EC 2.7.1.6
• Ignore hits to items matching galactokinase when looking for 'other' hits
• Comment: Some curated sequences match an HMM and are annotated as galactokinases, but without the EC number.

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 350-392 amino acids (not heteromeric)

P51570 galactokinase (EC 2.7.1.6) from Homo sapiens
GALK1_HUMAN / P51570 Galactokinase; Galactose kinase; EC 2.7.1.6 from Homo sapiens (Human)
P51570 galactokinase (EC 2.7.1.6) from Homo sapiens
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
392 amino acids: PaperBLAST, CDD, Compare to cluster

Q9GKK4 galactokinase (EC 2.7.1.6) from Canis lupus familiaris
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
392 amino acids: PaperBLAST, CDD, Compare to cluster

b0757 galactokinase (EC 2.7.1.6) from Escherichia coli K-12 substr. MG1655
P0A6T3 galactokinase (EC 2.7.1.6) from Escherichia coli (strain K12)
GAL1_ECOLI / P0A6T3 Galactokinase; Galactose kinase; EC 2.7.1.6 from Escherichia coli (strain K12)
MB|P0A6T3 galactose kinase from Escherichia coli K12
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
382 amino acids: PaperBLAST, CDD, Compare to cluster

GAL1_PYRHO / O58107 Galactokinase; Galactose kinase; EC 2.7.1.6 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
350 amino acids: PaperBLAST, CDD, Compare to cluster

GAL1_PYRFU / Q9HHB6 Galactokinase; Galactose kinase; EC 2.7.1.6 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
352 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS06125 Galactokinase (EC 2.7.1.6) from Pedobacter sp. GW460-11-11-14-LB5
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
383 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 496-520 amino acids (not heteromeric)

GAL3_YEAST / P13045 Protein GAL3 (from HMM only) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
520 amino acids: PaperBLAST, CDD, Compare to cluster

GALK1_ARATH / Q9SEE5 Galactokinase; Galactose kinase; EC 2.7.1.6 from Arabidopsis thaliana (Mouse-ear cress)
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
496 amino acids: PaperBLAST, CDD, Compare to cluster

B6V3B9 galactokinase (EC 2.7.1.6) from Cucumis melo
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
500 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 463-468 amino acids (not heteromeric)

Q4DF18 galactokinase (EC 2.7.1.6) from Trypanosoma cruzi
PFams: GalKase_gal_bdg, GHMP_kinases_C
468 amino acids: PaperBLAST, CDD, Compare to cluster

Q4DFH6 galactokinase (EC 2.7.1.6) from Trypanosoma cruzi
PFams: GalKase_gal_bdg, GHMP_kinases_N, GHMP_kinases_C
463 amino acids: PaperBLAST, CDD, Compare to cluster