Clusters of Characterized Proteins

Clustering the characterized proteins for gtsA (glucose ABC transporter, substrate-binding component (GtsA)) in lactose catabolism

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Definition of gtsA

• Curated sequence Q88P38: GtsA (GLcE), component of Glucose porter, GtsABCD
• Curated sequence Q72KX2: Glucose-binding protein aka TT_C0328, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25)
• Curated sequence PfGW456L13_1894: ABC transporter for D-Galactose and D-Glucose, periplasmic substrate-binding component
• Curated sequence GFF4324: ABC transporter for D-Glucose-6-Phosphate, periplasmic substrate-binding component
• UniProt sequence A0A165KPY4: SubName: Full=Sugar ABC transporter substrate-binding protein {ECO:0000313|EMBL:KZT15782.1};
• Comment: gtsABCD-like ABC transporters, from Thermus, Pseudomonas putida, and Pseudomonas fluorescens GW456-L13. (Some components cluster with glcSTUV from Saccharolobus, which is described separately; those are marked ignore here.) The system in P. fluorescens is very similar (~90% a.a. identity) to PS417_22145:PS417_22130 (GFF4324:GFF4321), which is involved in glucose-6-phosphate utilization, probably as a glucose transporter. Fitness data also identified a gtsABCD-like glucose transporter in Acidovorax sp. GW101-3H11 (Ac3H11_2062:Ac3H11_2064:Ac3H11_2065:Ac3H11_2066; A0A165KPY4, A0A165KPZ4, A0A165KQ00, A0A165KQ08).

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 414-432 amino acids (4/5 heteromeric)

TC 3.A.1.1.30 / Q88P38 GtsA (GLcE), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440)
Heteromeric, 428 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.1.24 / Q72KX2 Glucose-binding protein aka TT_C0328, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
PFams: SBP_bac_1, SBP_bac_8
Heteromeric, 414 amino acids: PaperBLAST, CDD, Compare to cluster

A0A165KPY4 Sugar ABC transporter substrate-binding protein
416 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_22145 ABC transporter for D-Glucose-6-Phosphate, periplasmic substrate-binding component from Pseudomonas simiae WCS417
Heteromeric, 428 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_1894 ABC transporter for D-Galactose and D-Glucose, periplasmic substrate-binding component from Pseudomonas fluorescens GW456-L13
Heteromeric, 432 amino acids: PaperBLAST, CDD, Compare to cluster