Clusters of Characterized Proteins

Clustering the characterized proteins for lacA' (periplasmic lactose 3-dehydrogenase, LacA subunit) in lactose catabolism

Or see other characterized proteins similar to lacA'

Or see all steps for lactose catabolism

Or cluster curated proteins matching a keyword

Definition of lacA'

• Curated sequence CCNA_01706: lactose 3-dehydrogenase flavin subunit (EC 1.1.99.13). lacA: subunit of periplasmic glucoside 3-dehydrogenase (EC 1.1.99.13)
• Curated sequence CA265_RS15345: periplasmic glucoside 3-dehydrogenase (lacA subunit) (EC 1.1.99.13)
• Ignore hits to items matching 1.1.99.13 when looking for 'other' hits
• Comment: LacACB from Caulobacter is the best studied lactose 3-dehydrogenase, but a related system from Pedobacter is also required for lactose utilization. EC 1.1.99.13 includes 3-ketoglycoside dehydrogenases more broadly. Other types of periplasmic 3-ketoglycoside dehydrogenases have been reported (ThuAB from Agrobacterium and Sinorhizobium and BT2158 from Bacteroides thetaiotaomicron) but these do not seem to be involved in lactose utilization. To avoid confusion with galactose catabolism genes, these are named lacA' etc. in GapMind.

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 567-579 amino acids (heteromeric)

CCNA_01706 lacA: subunit of periplasmic glucoside 3-dehydrogenase (EC 1.1.99.13) from Caulobacter crescentus NA1000
Q9A7T6 lactose 3-dehydrogenase flavin subunit (EC 1.1.99.13) from Caulobacter vibrioides (strain ATCC 19089 / CB15)
PFams: FAD_binding_2, GMC_oxred_N, GMC_oxred_C
Heteromeric, 579 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS15345 periplasmic glucoside 3-dehydrogenase (lacA subunit) (EC 1.1.99.13) from Pedobacter sp. GW460-11-11-14-LB5
PFams: GMC_oxred_N, GMC_oxred_C
Heteromeric, 567 amino acids: PaperBLAST, CDD, Compare to cluster