Clusters of Characterized Proteins

Clustering the characterized proteins for manX (glucose PTS, enzyme EIIAB) in lactose catabolism

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Definition of manX

• Curated sequence CH_088329: PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191. PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose. mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IIAB component
• Curated sequence E1UCI0: PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN
• Curated sequence Q04GK1: Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system
• Curated sequence Q2QKM4: ManL aka EIIAB, component of Glucose porter, ManLMN
• Curated sequence Q5M5W6: ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
• Ignore hits to Q9S4L5 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
• Ignore hits to D2BKY7 when looking for 'other' hits (Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine)
• Comment: PTS system manXYZ (manX is EIIAB; manY is EIIC; manZ is EIID) from E. coli, Listeria, Oenococcus, Lactobacillus, and Streptococcus. Systems related to manXYZ in Streptococcus salivarius and Lactococcus lactis subsp. lactis are reported to act on glucose, but are listed with other preferred substrates; ignore these.

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 321-331 amino acids (heteromeric)

b1817 mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655
P69797 mannose-specific PTS enzyme IIAB component from Escherichia coli (strain K12)
PTNAB_ECOLI / P69797 PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191 from Escherichia coli (strain K12)
TC 4.A.6.1.1 / P69797 PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli
RF|NP_416331.1 PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 323 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.15 / E1UCI0 PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 321 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.10 / Q04GK1 Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 331 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.6 / Q2QKM4 ManL aka EIIAB, component of Glucose porter, ManLMN from Lactobacillus casei
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 324 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.7 / Q5M5W6 ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 330 amino acids: PaperBLAST, CDD, Compare to cluster