Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for manY (glucose PTS, enzyme EIIC) in lactose catabolism

Or see other characterized proteins similar to manY

Or see all steps for lactose catabolism

Or cluster curated proteins matching a keyword

Definition of manY

Curated sequence CH_088330: mannose permease IIC component. PTS system mannose-specific EIIC component; EII-P-Man; EIIC-Man; Mannose permease IIC component. PTNC aka MANY aka PTSP aka PEL aka B1818, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose. mannose-specific PTS enzyme IIC component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IIC component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193)
Curated sequence E1UCI1: PTS system, mannose/fructose/sorbose family, IIC component, component of The primary glucose /mannose uptake transporter, ManLMN
Curated sequence Q04GK0: Mannose-specific PTS system component IIC, component of The hexose (glucose and fructose demonstrated) PTS uptake system
Curated sequence Q2QKM3: ManM aka EIIC, component of Glucose porter, ManLMN
Curated sequence Q5M5W7: ManM, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
Comment: Also similar is Lmo0782 (TC 4.A.6.1.16 / Q8Y8W0) from MpoABCD, a PTS-like glucose sensor; this is not ignored but possibly should be.

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 266-275 amino acids (heteromeric)

The first sequence in each cluster is the seed.

b1818 mannose-specific PTS enzyme IIC component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655
P69801 mannose-specific PTS enzyme IIC component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli (strain K12)
PTNC_ECOLI / P69801 PTS system mannose-specific EIIC component; EII-P-Man; EIIC-Man; Mannose permease IIC component from Escherichia coli (strain K12)
TC 4.A.6.1.1 / P69801 PTNC aka MANY aka PTSP aka PEL aka B1818, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli
CH_088330 mannose permease IIC component from Escherichia coli K12
PFams: EII-Sor
Heteromeric, 266 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.15 / E1UCI1 PTS system, mannose/fructose/sorbose family, IIC component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EII-Sor
Heteromeric, 268 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.10 / Q04GK0 Mannose-specific PTS system component IIC, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EII-Sor
Heteromeric, 271 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.6 / Q2QKM3 ManM aka EIIC, component of Glucose porter, ManLMN from Lactobacillus casei
PFams: EII-Sor
Heteromeric, 271 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.7 / Q5M5W7 ManM, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EII-Sor
Heteromeric, 275 amino acids: PaperBLAST, CDD, Compare to cluster