Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for manZ (glucose PTS, enzyme EIID) in lactose catabolism

Or see other characterized proteins similar to manZ

Or see all steps for lactose catabolism

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Definition of manZ

Curated sequence P69805: PTS system mannose-specific EIID component; EII-M-Man; EIID-Man; Mannose permease IID component. mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193)
Curated sequence E1UCI2: PTS system, mannose/fructose/sorbose family, IID component, component of The primary glucose /mannose uptake transporter, ManLMN
Curated sequence P69805: PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose
Curated sequence Q04GJ9: PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system
Curated sequence Q2QKM2: ManN aka EIID, component of Glucose porter, ManLMN
Curated sequence Q5M5W8: ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN
Ignore hits to Q5IRC0 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
Ignore hits to D2BKY9 when looking for 'other' hits (Mannose-specific PTS system, IID component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine)
Comment: (The E. coli entry, P69805, is listed twice, because the sequence in TCDB has 3 extra N-terminal residues.) Also similar is Lmo0781 (TC 4.A.6.1.16 / Q8Y8W1) from MpoABCD; should perhaps be ignored.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 283-304 amino acids (heteromeric)

The first sequence in each cluster is the seed.

b1819 mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655
P69805 mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli (strain K12)
PTND_ECOLI / P69805 PTS system mannose-specific EIID component; EII-M-Man; EIID-Man; Mannose permease IID component from Escherichia coli (strain K12)
PFams: EIID-AGA
Heteromeric, 283 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.15 / E1UCI2 PTS system, mannose/fructose/sorbose family, IID component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.1 / P69805 PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli
PFams: EIID-AGA
Heteromeric, 286 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.10 / Q04GJ9 PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1)
PFams: EIID-AGA
Heteromeric, 304 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.6 / Q2QKM2 ManN aka EIID, component of Glucose porter, ManLMN from Lactobacillus casei
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD, Compare to cluster

TC 4.A.6.1.7 / Q5M5W8 ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: EIID-AGA
Heteromeric, 303 amino acids: PaperBLAST, CDD, Compare to cluster