Clusters of Characterized Proteins

Clustering the characterized proteins for mglA (glucose ABC transporter, ATP-binding component (MglA)) in lactose catabolism

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Definition of mglA

• Ignore hits to D4GPW3 when looking for 'other' hits (Glucose import ATP-binding protein TsgD13; EC 7.5.2.-)
• Curated sequence G4FGN3: Monosaccharide-transporting ATPase, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR
• Curated sequence O05176: GguA aka ATU2347 aka AGR_C_4264, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter
• Curated sequence P0AAG8: Galactose/methyl galactoside import ATP-binding protein MglA aka B2149, component of Galactose/glucose (methyl galactoside) porter. D-galactose/methyl-galactoside ABC transporter ATP binding subunit. D-galactose/methyl-galactoside ABC transporter ATP binding subunit
• Curated sequence GFF3641: glucose transporter, ATPase component
• Ignore hits to P23924 when looking for 'other' hits (Galactose/methyl galactoside import ATP-binding protein MglA; EC 7.5.2.11)
• Comment: mglABC-like ABC transporters, from E. coli, Haloferax, Thermotoga, Agrobacterium, and Phaeobacter. But in Haloferax, only two components are known; there is a SBP nearby but also a second permease. So mark TSGDD_HALVD / D4GPW3 and D4GPW2 as ignore. Also, there is one paper about the Salmonella ortholog of mglABC; not clear if that transports glucose or not, so ignore that as well (P23924).

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 494-512 amino acids (heteromeric)

TC 3.A.1.2.20 / G4FGN3 Monosaccharide-transporting ATPase, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: ABC_tran, ABC_tran
Heteromeric, 494 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.2.5 / O05176 GguA aka ATU2347 aka AGR_C_4264, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter from Agrobacterium radiobacter
PFams: ABC_tran, ABC_tran
Heteromeric, 512 amino acids: PaperBLAST, CDD, Compare to cluster

b2149 D-galactose/methyl-galactoside ABC transporter ATP binding subunit from Escherichia coli K-12 substr. MG1655
P0AAG8 D-galactose/methyl-galactoside ABC transporter ATP binding subunit from Escherichia coli (strain K12)
TC 3.A.1.2.3 / P0AAG8 Galactose/methyl galactoside import ATP-binding protein MglA aka B2149, component of Galactose/glucose (methyl galactoside) porter from Escherichia coli
PFams: ABC_tran, ABC_tran
Heteromeric, 506 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (1/1 heteromeric)

PGA1_262p00450 glucose transporter, ATPase component from Phaeobacter inhibens BS107
PFams: ABC_tran
Heteromeric, 260 amino acids: PaperBLAST, CDD