Clusters of Characterized Proteins

Clustering the characterized proteins for mglB (glucose ABC transporter, substrate-binding component) in lactose catabolism

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Definition of mglB

• Curated sequence P0AEE5: D-galactose-binding periplasmic protein DGAL aka MglB aka B2150, component of Galactose/glucose (methyl galactoside) porter. D-galactose/methyl-galactoside ABC transporter periplasmic binding protein. D-galactose/methyl-galactoside ABC transporter periplasmic binding protein
• Curated sequence P25548: CVE1 aka ChvE aka ATU2348 aka AGR_C_4267, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter
• Curated sequence GFF3639: glucose transporter, periplasmic substrate-binding component
• Curated sequence G4FGN5: LacI family transcriptional regulator, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR
• Ignore hits to P54083 when looking for 'other' hits (Multiple sugar-binding periplasmic protein SbpA; Sugar-binding protein A)
• Comment: mglB (b2150) from E. coli (P0AEE5; 332 a.a.), chvE, or TC 3.A.1.2.20 / G4FGN5 in Thermotoga (343 a.a.) [absent from Haloferax]. Ignore SBPA_AZOBR / P54083 from Azospirillum, whose substrate specificity is uncertain.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 1 of these sequences

Found 1 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 341-354 amino acids (heteromeric)

TC 3.A.1.2.5 / P25548 CVE1 aka ChvE aka ATU2348 aka AGR_C_4267, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter from Agrobacterium tumefaciens
PFams: Peripla_BP_1, Peripla_BP_4
Heteromeric, 354 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_262p00430 glucose transporter, periplasmic substrate-binding component from Phaeobacter inhibens BS107
PFams: Peripla_BP_4, Peripla_BP_1, Peripla_BP_3
Heteromeric, 341 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (2/2 heteromeric)

TC 3.A.1.2.20 / G4FGN5 LacI family transcriptional regulator, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: Peripla_BP_1, Peripla_BP_4, ABC_sub_bind
Heteromeric, 343 amino acids: PaperBLAST, CDD

b2150 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein from Escherichia coli K-12 substr. MG1655
P0AEE5 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein from Escherichia coli (strain K12)
TC 3.A.1.2.3 / P0AEE5 D-galactose-binding periplasmic protein DGAL aka MglB aka B2150, component of Galactose/glucose (methyl galactoside) porter from Escherichia coli
PFams: Peripla_BP_4, Peripla_BP_1, Peripla_BP_3
Heteromeric, 332 amino acids: PaperBLAST, CDD