Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for ilvD (dihydroxy-acid dehydratase) in L-leucine biosynthesis

Or see other characterized proteins similar to ilvD

Or see all steps for L-leucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of ilvD

Curated proteins or TIGRFams with EC 4.2.1.9
Ignore hits to MONOMER-15882 when looking for 'other' hits (dihydroxy-acid dehydratase)
Comment: IlvD is involved in the biosynthesis of isoleucine, with (R)-2,3-dihydroxy-3-methylpentanoate as the substrate, and in the biosynthesis of valine and leucine, with (R)-2,3-dihydroxy-3-methylbutanoate as the substrate. The ignored enzyme is involved in salinosporamide A biosynthesis but does a very similar reaction and is >50% identical to N515DRAFT_0569, which is confirmed by fitness data to be biosynthetic

Fetched 12 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 12 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 549-617 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A0A481UJA7 dihydroxy-acid dehydratase (EC 4.2.1.9) from Hevea brasiliensis
PFams: ILVD_EDD
614 amino acids: PaperBLAST, CDD, Compare to cluster

Q8NQZ9 dihydroxy-acid dehydratase (EC 4.2.1.9) from Corynebacterium glutamicum
PFams: ILVD_EDD
613 amino acids: PaperBLAST, CDD, Compare to cluster

Q97UB2 dihydroxy-acid dehydratase (EC 4.2.1.9) from Saccharolobus solfataricus
PFams: ILVD_EDD
558 amino acids: PaperBLAST, CDD, Compare to cluster

ILVD_ARATH / Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress)
Q9LIR4 dihydroxy-acid dehydratase (EC 4.2.1.9) from Arabidopsis thaliana
PFams: ILVD_EDD
608 amino acids: PaperBLAST, CDD, Compare to cluster

b3771 dihydroxy-acid dehydratase (EC 4.2.1.9) from Escherichia coli K-12 substr. MG1655
P05791 dihydroxy-acid dehydratase (EC 4.2.1.9) from Escherichia coli (strain K12)
ILVD_ECOLI / P05791 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Escherichia coli (strain K12)
EW|b3771 dihydroxyacid dehydratase from Escherichia coli K12
PFams: ILVD_EDD
616 amino acids: PaperBLAST, CDD, Compare to cluster

ILV3_YEAST / P39522 Dihydroxy-acid dehydratase, mitochondrial; DAD; EC 4.2.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: ILVD_EDD
585 amino acids: PaperBLAST, CDD, Compare to cluster

ILVD_CAUVC / P55186 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
PFams: ILVD_EDD
617 amino acids: PaperBLAST, CDD, Compare to cluster

ILVD_MYCTU / P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: ILVD_EDD
575 amino acids: PaperBLAST, CDD, Compare to cluster

ILVD_RHIL3 / Q1MIB2 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Rhizobium leguminosarum bv. viciae (strain 3841)
PFams: ILVD_EDD
612 amino acids: PaperBLAST, CDD, Compare to cluster

ILVC_ASPFU / Q4X099 Dihydroxy-acid dehydratase ilvC, mitochondrial; DHAD ilvC; EC 4.2.1.9 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
PFams: ILVD_EDD
606 amino acids: PaperBLAST, CDD, Compare to cluster

O27498 dihydroxy-acid dehydratase subunit (EC 4.2.1.9) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
PFams: ILVD_EDD
549 amino acids: PaperBLAST, CDD, Compare to cluster

Q0K7F8 dihydroxyacid dehydratase (EC 4.2.1.9) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
Q0K7F8 dihydroxy-acid dehydratase (EC 4.2.1.9) from Cupriavidus necator
PFams: ILVD_EDD
557 amino acids: PaperBLAST, CDD, Compare to cluster