Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for ilvE (leucine transaminase) in L-leucine biosynthesis

Or see other characterized proteins similar to ilvE

Or see all steps for L-leucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of ilvE

Curated proteins or TIGRFams with EC 2.6.1.6
Curated proteins or TIGRFams with EC 2.6.1.42
Ignore hits to Q8NS92 when looking for 'other' hits (HTH-type pyridoxine biosynthesis transcriptional regulator PdxR)
Ignore hits to items matching 2.6.1.57 when looking for 'other' hits
Ignore hits to items matching 2.6.1.5 when looking for 'other' hits
Comment: Q8NS92 is ignored because it is primarily a transcriptional regulator. Similarity to aromatic amino acid transaminases or tyrosine transaminases is ignored as they are often non-specific.

Fetched 60 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 58 of these sequences

Found 3 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 305-427 amino acids (not heteromeric)

Q5FTR3 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Gluconobacter oxydans
PFams: Aminotran_4
379 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0A0KG15 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Cucumis sativus var. sativus
PFams: Aminotran_4
405 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0A0LN48 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Cucumis sativus var. sativus
PFams: Aminotran_4
390 amino acids: PaperBLAST, CDD, Compare to cluster

A0A2Z4MEX9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Brevibacillus brevis
PFams: Aminotran_4
357 amino acids: PaperBLAST, CDD, Compare to cluster

A0A5Q8BPF5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Lacticaseibacillus paracasei
PFams: Aminotran_4
343 amino acids: PaperBLAST, CDD, Compare to cluster

ILVE_MYCS2 / A0R066 Branched-chain-amino-acid aminotransferase; BCAT; EC 2.6.1.42 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
A0R066 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Mycolicibacterium smegmatis
PFams: Aminotran_4
368 amino acids: PaperBLAST, CDD, Compare to cluster

B6RFK8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Nicotiana benthamiana
PFams: Aminotran_4
418 amino acids: PaperBLAST, CDD, Compare to cluster

B9L0B7 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermomicrobium roseum
PFams: Aminotran_4
320 amino acids: PaperBLAST, CDD, Compare to cluster

D1CCW1 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermobaculum terrenum
PFams: Aminotran_4
316 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_HUMAN / O15382 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT(m); Placental protein 18; PP18; EC 2.6.1.42 from Homo sapiens (Human)
O15382 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Homo sapiens
PFams: Aminotran_4
392 amino acids: PaperBLAST, CDD, Compare to cluster

O26004 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Helicobacter pylori
PFams: Aminotran_4
340 amino acids: PaperBLAST, CDD, Compare to cluster

O35855 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Mus musculus
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

O86428 branched-chain-amino-acid aminotransferase subunit (EC 2.6.1.6; EC 2.6.1.42) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
O86428 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Pseudomonas aeruginosa
PFams: Aminotran_4
307 amino acids: PaperBLAST, CDD, Compare to cluster

P38891 branched-chain amino acid aminotransferase subunit (EC 2.6.1.42; EC 2.6.1.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
BCA1_YEAST / P38891 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT; Protein ECA39; Protein TWT1; EC 2.6.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P38891 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Saccharomyces cerevisiae
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

BCA2_YEAST / P47176 Branched-chain-amino-acid aminotransferase, cytosolic; BCAT; Protein TWT2; EC 2.6.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P47176 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Saccharomyces cerevisiae
PFams: Aminotran_4
376 amino acids: PaperBLAST, CDD, Compare to cluster

ILVE_MYCTU / P9WQ75 Branched-chain-amino-acid aminotransferase; BCAT; EC 2.6.1.42 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WQ75 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Mycobacterium tuberculosis
PFams: Aminotran_4
368 amino acids: PaperBLAST, CDD, Compare to cluster

Q0E9S8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Helicobacter pylori
PFams: Aminotran_4
340 amino acids: PaperBLAST, CDD, Compare to cluster

Q70KX9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Hordeum vulgare
PFams: Aminotran_4
397 amino acids: PaperBLAST, CDD, Compare to cluster

Q7BPX6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Lactococcus lactis
PFams: Aminotran_4
340 amino acids: PaperBLAST, CDD, Compare to cluster

Q8DTW7 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Streptococcus mutans
PFams: Aminotran_4
341 amino acids: PaperBLAST, CDD, Compare to cluster

Q93Y32 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
384 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FYA6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
415 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LE06 methionine transaminase (EC 2.6.1.88) from Arabidopsis thaliana
BCAT4_ARATH / Q9LE06 Methionine aminotransferase BCAT4; Branched-chain-amino-acid aminotransferase 4; Atbcat-4; Methionine-oxo-acid transaminase BCAT4; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress)
Q9LE06 branched-chain-amino-acid transaminase (EC 2.6.1.42); methionine transaminase (EC 2.6.1.88) from Arabidopsis thaliana
PFams: Aminotran_4
354 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LPM9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
356 amino acids: PaperBLAST, CDD, Compare to cluster

Q9M401 branched-chain aminotransferase from Arabidopsis thaliana
BCAT3_ARATH / Q9M401 Branched-chain-amino-acid aminotransferase 3, chloroplastic; Atbcat-3; EC 2.6.1.42; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress)
Q9M401 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
413 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_ARATH / Q9M439 Branched-chain-amino-acid aminotransferase 2, chloroplastic; Atbcat-2; EC 2.6.1.42 from Arabidopsis thaliana (Mouse-ear cress)
Q9M439 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
388 amino acids: PaperBLAST, CDD, Compare to cluster

Q9RTX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Deinococcus radiodurans
PFams: Aminotran_4
358 amino acids: PaperBLAST, CDD, Compare to cluster

b3770 branched-chain-amino-acid aminotransferase (EC 2.6.1.1; EC 2.6.1.57; EC 2.6.1.27; EC 2.6.1.42; EC 2.6.1.6) from Escherichia coli K-12 substr. MG1655
P0AB80 branched-chain-amino-acid aminotransferase (EC 2.6.1.1; EC 2.6.1.42; EC 2.6.1.6) from Escherichia coli (strain K12)
RF|YP_026247 branched-chain-amino-acid aminotransferase; EC 2.6.1.42 from Escherichia coli K12
PFams: Aminotran_4
309 amino acids: PaperBLAST, CDD, Compare to cluster

RF|NP_595180.1 branched chain amino acid aminotransferase Eca39; EC 2.6.1.42 from Schizosaccharomyces pombe
PFams: Aminotran_4
380 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_HUMLU / K7QHS5 Branched-chain amino acid aminotransferase 2, chloroplastic; HlBCAT2; EC 2.6.1.42 from Humulus lupulus (European hop)
PFams: Aminotran_4
408 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT1_HUMLU / K7QKH1 Branched-chain amino acid aminotransferase 1, mitochondrial; HlBCAT1; EC 2.6.1.42 from Humulus lupulus (European hop)
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

BCA1_SCHPO / O14370 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT; EC 2.6.1.42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
O14370 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Schizosaccharomyces pombe
PFams: Aminotran_4
427 amino acids: PaperBLAST, CDD, Compare to cluster

O31461 branched-chain amino acid aminotransferase (EC 2.6.1.6; EC 2.6.1.42) from Bacillus subtilis (strain 168)
ILVE1_BACSU / O31461 Branched-chain-amino-acid transaminase 1; BCAT 1; EC 2.6.1.42 from Bacillus subtilis (strain 168)
PFams: Aminotran_4
356 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_RAT / O35854 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT(m); EC 2.6.1.42 from Rattus norvegicus (Rat)
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

P39576 branched-chain amino acid aminotransferase (EC 2.6.1.42; EC 2.6.1.6) from Bacillus subtilis (strain 168)
ILVE2_BACSU / P39576 Branched-chain-amino-acid aminotransferase 2; BCAT 2; Vegetative protein 85; VEG85; EC 2.6.1.42 from Bacillus subtilis (strain 168)
PFams: Aminotran_4
363 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT_CAEEL / P54688 Branched-chain-amino-acid aminotransferase, cytosolic; BCAT; ECA39 protein; EC 2.6.1.42 from Caenorhabditis elegans
PFams: Aminotran_4
415 amino acids: PaperBLAST, CDD, Compare to cluster

ATNH_EMENI / Q5AV02 Branched-chain-amino-acid aminotransferase atnH; Aspercryptin biosynthesis cluster protein H; EC 2.6.1.- (from HMM only) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Aminotran_4
396 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT1_SHEEP / Q9GKM4 Branched-chain-amino-acid aminotransferase, cytosolic; BCAT(c); EC 2.6.1.42 from Ovis aries (Sheep)
Q9GKM4 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Ovis aries
PFams: Aminotran_4
385 amino acids: PaperBLAST, CDD, Compare to cluster

GLOG_GLAL2 / S3DQP8 Branched-chain amino acid aminotransferase gloG; L-homotyrosine biosynthesis sub-cluster protein gloG; Pneumocandin biosynthesis cluster protein G; EC 2.6.1.42 from Glarea lozoyensis (strain ATCC 20868 / MF5171)
PFams: Aminotran_4
358 amino acids: PaperBLAST, CDD, Compare to cluster

O27481 branched-chain-amino-acid aminotransferase subunit (EC 2.6.1.42) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
PFams: Aminotran_4
306 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS16285 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Burkholderia phytofirmans PsJN
PFams: Aminotran_4
307 amino acids: PaperBLAST, CDD, Compare to cluster

RR42_RS25890 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Cupriavidus basilensis FW507-4G11
PFams: Aminotran_4
363 amino acids: PaperBLAST, CDD, Compare to cluster

N515DRAFT_2015 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Dyella japonica UNC79MFTsu3.2
PFams: Aminotran_4
305 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_0450 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Pseudomonas stutzeri RCH2
PFams: Aminotran_4
307 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_22970 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Pseudomonas fluorescens FW300-N2C3
PFams: Aminotran_4
339 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 286-317 amino acids (not heteromeric)

F0QW25 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Vulcanisaeta moutnovskia
PFams: Aminotran_4
314 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1B1L2T7 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Bacillus thuringiensis
PFams: Aminotran_4
298 amino acids: PaperBLAST, CDD, Compare to cluster

A6UP94 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Methanococcus vannielii
PFams: Aminotran_4
303 amino acids: PaperBLAST, CDD, Compare to cluster

D0LR31 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Haliangium ochraceum
PFams: Aminotran_4
317 amino acids: PaperBLAST, CDD, Compare to cluster

E6TUA8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Evansella cellulosilytica
PFams: Aminotran_4
302 amino acids: PaperBLAST, CDD, Compare to cluster

F2L0W0 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermoproteus uzoniensis
PFams: Aminotran_4
295 amino acids: PaperBLAST, CDD, Compare to cluster

P54691 branched-chain-amino-acid transaminase (EC 2.6.1.42); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Synechocystis sp.
PFams: Aminotran_4
305 amino acids: PaperBLAST, CDD, Compare to cluster

GB|AAU18968.1 branched-chain amino acid aminotransferase 2; EC 2.6.1.42 from Bacillus cereus E33L
PFams: Aminotran_4
298 amino acids: PaperBLAST, CDD, Compare to cluster

A6UWA0 branched-chain amino acid aminotransferase subunit (EC 2.6.1.6; EC 2.6.1.42) from Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
A6UWA0 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Methanococcus aeolicus
PFams: Aminotran_4
286 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 393-417 amino acids (not heteromeric)

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp.
PFams: Aminotran_1_2, Asp_aminotransf
417 amino acids: PaperBLAST, CDD, Compare to cluster

BWI76_RS24235 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Klebsiella michiganensis M5al
PFams: Aminotran_1_2, Asp_aminotransf
393 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Asp_aminotransf
401 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS06555 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Azospirillum brasilense Sp245
PFams: Aminotran_1_2, DegT_DnrJ_EryC1, Asp_aminotransf
404 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

A0A0A0LJI6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Cucumis sativus var. sativus
PFams: Sulfotransfer_5, Aminotran_4
555 amino acids: PaperBLAST, CDD

b4054 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.42; EC 2.6.1.1; EC 2.6.1.5; EC 2.6.1.27) from Escherichia coli K-12 substr. MG1655
P04693 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.1) from Escherichia coli (strain K12)
TYRB_ECOLI / P04693 Aromatic-amino-acid aminotransferase; ARAT; AROAT; Beta-methylphenylalanine transaminase; EC 2.6.1.57; EC 2.6.1.107 from Escherichia coli (strain K12)
P04693 aromatic-amino-acid transaminase (EC 2.6.1.57) from Escherichia coli
GB|AAC77024.1 aromatic-amino-acid transaminase TyrB; EC 2.6.1.57 from Escherichia coli K12
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD