Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for atoB (acetyl-CoA C-acetyltransferase) in L-leucine catabolism

Or see other characterized proteins similar to atoB

Or see all steps for L-leucine catabolism

Or cluster curated proteins matching a keyword

Definition of atoB

Curated proteins or TIGRFams with EC 2.3.1.9
Ignore hits to items matching 2.3.1.16 when looking for 'other' hits
Ignore hits to P07256 when looking for 'other' hits (acetyl-CoA C-acetyltransferase (EC 2.3.1.9). Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome c oxidoreductase core protein 1; Ubiquinol-cytochrome c reductase 44 kDa protein)
Ignore hits to I3R3D0 when looking for 'other' hits (acetyl-CoA C-acetyltransferase (subunit 1/2) (EC 2.3.1.9))
Ignore hits to I3RA71 when looking for 'other' hits (acetyl-CoA C-acetyltransferase (subunit 1/2) (EC 2.3.1.9))
Ignore hits to items matching similar to acetyl-CoA acetyltransferase when looking for 'other' hits
Comment: Produces two acetyl-CoA from acetoacetyl-CoA and CoA. EC 2.3.1.16 describes a broader range of beta-ketothiolases. This enzyme is usually homomeric, but I3R3D0 and I3RA71 are non-catalytic subunits of an enzyme from Haloferax mediterranei that also contains a "normal" catalytic subunit (I3R3D1, I3RA72). Inclusion of P07256 was an error in BRENDA. And CharProtDB includes an odd annotation of the form "similar to acetyl-CoA acetyltransferase"

Fetched 36 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 35 of these sequences

Found 2 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 391-427 amino acids (not heteromeric)

A4YEH9 acetyl-CoA C-acetyltransferase (EC 2.3.1.16) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YEH9 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Metallosphaera sedula
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
395 amino acids: PaperBLAST, CDD, Compare to cluster

B1YB71 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Pyrobaculum neutrophilum
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
392 amino acids: PaperBLAST, CDD, Compare to cluster

B7XEI5 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Ostrinia scapulalis
PFams: Thiolase_N, Thiolase_C
396 amino acids: PaperBLAST, CDD, Compare to cluster

D0EUY6 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Medicago sativa
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

D2IH11 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Helianthus annuus
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
411 amino acids: PaperBLAST, CDD, Compare to cluster

P42765 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) from Homo sapiens
THIM_HUMAN / P42765 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Homo sapiens (Human)
P42765 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Homo sapiens
PFams: Thiolase_N, Thiolase_C
397 amino acids: PaperBLAST, CDD, Compare to cluster

P45359 acetoacetyl-CoA thiolase monomer (EC 2.3.1.16) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
P45359 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Clostridium acetobutylicum
PFams: Thiolase_N, SpoVAD, ketoacyl-synt, Thiolase_C
392 amino acids: PaperBLAST, CDD, Compare to cluster

Q0K368 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Cupriavidus necator
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
391 amino acids: PaperBLAST, CDD, Compare to cluster

Q0KAI3 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Cupriavidus necator
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
392 amino acids: PaperBLAST, CDD, Compare to cluster

Q86AD9 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Dictyostelium discoideum
PFams: Thiolase_N, Thiolase_C
414 amino acids: PaperBLAST, CDD, Compare to cluster

Q8S4Y1 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Arabidopsis thaliana
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

THIKB_MOUSE / Q8VCH0 3-ketoacyl-CoA thiolase B, peroxisomal; Acetyl-CoA acyltransferase B; Beta-ketothiolase B; Peroxisomal 3-oxoacyl-CoA thiolase B; EC 2.3.1.155; EC 2.3.1.16; EC 2.3.1.9 from Mus musculus (Mouse)
Q8VCH0 acetyl-CoA C-acyltransferase (EC 2.3.1.16) from Mus musculus
PFams: Thiolase_N, Thiolase_C
424 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FIK7 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Arabidopsis thaliana
PFams: Thiolase_N, Thiolase_C
415 amino acids: PaperBLAST, CDD, Compare to cluster

THIL_ZOORA / P07097 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Zoogloea ramigera
PFams: Thiolase_N, Thiolase_C
392 amino acids: PaperBLAST, CDD, Compare to cluster

THIKB_RAT / P07871 3-ketoacyl-CoA thiolase B, peroxisomal; Acetyl-CoA acyltransferase B; Beta-ketothiolase B; Peroxisomal 3-oxoacyl-CoA thiolase B; EC 2.3.1.155; EC 2.3.1.16; EC 2.3.1.9 from Rattus norvegicus (Rat)
PFams: Thiolase_N, Thiolase_C
424 amino acids: PaperBLAST, CDD, Compare to cluster

THIM_RAT / P13437 3-ketoacyl-CoA thiolase, mitochondrial; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; EC 2.3.1.16; EC 2.3.1.9; EC 3.1.2.-; EC 3.1.2.1; EC 3.1.2.2 from Rattus norvegicus (Rat)
PFams: Thiolase_N, Thiolase_C
397 amino acids: PaperBLAST, CDD, Compare to cluster

P14611 acetyl-CoA acetyltransferase subunit (EC 2.3.1.16) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
THIL_CUPNH / P14611 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
393 amino acids: PaperBLAST, CDD, Compare to cluster

P24752 acetyl-CoA acetyltransferase monomer (EC 2.3.1.16) from Homo sapiens
THIL_HUMAN / P24752 Acetyl-CoA acetyltransferase, mitochondrial; Acetoacetyl-CoA thiolase; T2; EC 2.3.1.9 from Homo sapiens (Human)
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
427 amino acids: PaperBLAST, CDD, Compare to cluster

P41338 Erg10 (EC 2.3.1.16) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
THIL_YEAST / P41338 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10; EC 2.3.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
398 amino acids: PaperBLAST, CDD, Compare to cluster

THIL_THIVI / P45363 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Thiocystis violacea
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
394 amino acids: PaperBLAST, CDD, Compare to cluster

THIL_ALLVD / P45369 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) (Chromatium vinosum)
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
394 amino acids: PaperBLAST, CDD, Compare to cluster

THL_BACSU / P45855 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Bacillus subtilis (strain 168)
PFams: Thiolase_N, Thiolase_C
393 amino acids: PaperBLAST, CDD, Compare to cluster

SMc03879 Acetyl-CoA acetyltransferase (EC 2.3.1.9) from Sinorhizobium meliloti 1021
THIL_RHIME / P50174 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Beta-ketothiolase; EC 2.3.1.9 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
PFams: Thiolase_N, Thiolase_C
393 amino acids: PaperBLAST, CDD, Compare to cluster

THIL_SYNY3 / P73825 Acetyl-CoA acetyltransferase; Beta-ketothiolase PhaA; EC 2.3.1.9 from Synechocystis sp. (strain PCC 6803 / Kazusa)
PFams: Thiolase_N, Thiolase_C
396 amino acids: PaperBLAST, CDD, Compare to cluster

THLA_SYNWW / Q0AVM3 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; EC 2.3.1.9 from Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)
PFams: Thiolase_N, Thiolase_C
396 amino acids: PaperBLAST, CDD, Compare to cluster

Q0KBP1 β-ketothiolase (EC 2.3.1.16) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
BKTB_CUPNH / Q0KBP1 Beta-ketothiolase BktB; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; EC 2.3.1.16; EC 2.3.1.9 from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
394 amino acids: PaperBLAST, CDD, Compare to cluster

Q9BWD1 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Homo sapiens
THIC_HUMAN / Q9BWD1 Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; EC 2.3.1.9 from Homo sapiens (Human)
PFams: Thiolase_N, Thiolase_C
397 amino acids: PaperBLAST, CDD, Compare to cluster

THIL_SCHPO / Q9UQW6 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10; EC 2.3.1.9 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Thiolase_N, Thiolase_C
395 amino acids: PaperBLAST, CDD, Compare to cluster

b2224 acetyl-CoA acetyltransferase (EC 2.3.1.16; EC 2.3.1.9) from Escherichia coli K-12 substr. MG1655
P76461 acetyl-CoA acetyltransferase (EC 2.3.1.16) from Escherichia coli (strain K12)
PFams: Thiolase_N, Thiolase_C
394 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_c03400 acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) from Phaeobacter inhibens BS107
PFams: Thiolase_N, Thiolase_C
391 amino acids: PaperBLAST, CDD, Compare to cluster

PfGW456L13_2411 Acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Pseudomonas fluorescens GW456-L13
PFams: Thiolase_N, Thiolase_C
393 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_25685 acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) from Pseudomonas fluorescens FW300-N2E3
PFams: Thiolase_N, Thiolase_C
397 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_21640 acetyl-CoA C-acetyltransferase [EC: 2.3.1.9] from Pseudomonas fluorescens FW300-N2C3
PFams: Thiolase_N, ketoacyl-synt, Thiolase_C
393 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 383-383 amino acids (heteromeric)

I3R3D1 acetyl-CoA C-acetyltransferase (subunit 2/2) (EC 2.3.1.9) from Haloferax mediterranei
PFams: Thiolase_N, Thiolase_C
Heteromeric, 383 amino acids: PaperBLAST, CDD, Compare to cluster

I3RA72 acetyl-CoA C-acetyltransferase (subunit 2/2) (EC 2.3.1.9) from Haloferax mediterranei
PFams: Thiolase_N, Thiolase_C
Heteromeric, 383 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

G7YHN5 acetyl-CoA C-acetyltransferase (EC 2.3.1.9) from Clonorchis sinensis
PFams: Thiolase_N, Thiolase_C
284 amino acids: PaperBLAST, CDD