Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for ilvE (L-leucine transaminase) in L-leucine catabolism

Or see other characterized proteins similar to ilvE

Or see all steps for L-leucine catabolism

Or cluster curated proteins matching a keyword

Definition of ilvE

Curated proteins or TIGRFams with EC 2.6.1.6
Curated proteins or TIGRFams with EC 2.6.1.42
Comment: These enzymes transfer the amino group to 2-oxoglutarate to form glutamate; glutamate dehydrogenase (not included in the pathway definition) can then release the ammonia. Many other paths are possible but do not seem to be known (i.e., transfer to oxaloacetate followed by aspartate-ammonia lyase).

Fetched 48 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 46 of these sequences

Found 3 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 305-427 amino acids (not heteromeric)

ILVE_MYCS2 / A0R066 Branched-chain-amino-acid aminotransferase; BCAT; EC 2.6.1.42 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
A0R066 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Mycolicibacterium smegmatis
PFams: Aminotran_4
368 amino acids: PaperBLAST, CDD, Compare to cluster

B6RFK8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Nicotiana benthamiana
PFams: Aminotran_4
418 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_HUMAN / O15382 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT(m); Placental protein 18; PP18; EC 2.6.1.42 from Homo sapiens (Human)
O15382 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Homo sapiens
PFams: Aminotran_4
392 amino acids: PaperBLAST, CDD, Compare to cluster

O35855 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Mus musculus
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

b3770 branched-chain-amino-acid aminotransferase (EC 2.6.1.1; EC 2.6.1.57; EC 2.6.1.27; EC 2.6.1.42; EC 2.6.1.6) from Escherichia coli K-12 substr. MG1655
P0AB80 branched-chain-amino-acid aminotransferase (EC 2.6.1.1; EC 2.6.1.42; EC 2.6.1.6) from Escherichia coli (strain K12)
P0AB80 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Escherichia coli
RF|YP_026247 branched-chain-amino-acid aminotransferase; EC 2.6.1.42 from Escherichia coli K12
PFams: Aminotran_4
309 amino acids: PaperBLAST, CDD, Compare to cluster

P38891 branched-chain amino acid aminotransferase subunit (EC 2.6.1.42; EC 2.6.1.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
BCA1_YEAST / P38891 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT; Protein ECA39; Protein TWT1; EC 2.6.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P38891 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Saccharomyces cerevisiae
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

BCA2_YEAST / P47176 Branched-chain-amino-acid aminotransferase, cytosolic; BCAT; Protein TWT2; EC 2.6.1.42 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P47176 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Saccharomyces cerevisiae
PFams: Aminotran_4
376 amino acids: PaperBLAST, CDD, Compare to cluster

P54687 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Homo sapiens
PFams: Aminotran_4
386 amino acids: PaperBLAST, CDD, Compare to cluster

ILVE_MYCTU / P9WQ75 Branched-chain-amino-acid aminotransferase; BCAT; EC 2.6.1.42 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WQ75 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Mycobacterium tuberculosis
PFams: Aminotran_4
368 amino acids: PaperBLAST, CDD, Compare to cluster

Q0E9S8 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Helicobacter pylori
PFams: Aminotran_4
340 amino acids: PaperBLAST, CDD, Compare to cluster

Q70KX9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Hordeum vulgare
PFams: Aminotran_4
397 amino acids: PaperBLAST, CDD, Compare to cluster

Q7BPX6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Lactococcus lactis
PFams: Aminotran_4
340 amino acids: PaperBLAST, CDD, Compare to cluster

Q8DTW7 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Streptococcus mutans
PFams: Aminotran_4
341 amino acids: PaperBLAST, CDD, Compare to cluster

Q93Y32 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
384 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FYA6 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
415 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LE06 methionine transaminase (EC 2.6.1.88) from Arabidopsis thaliana
BCAT4_ARATH / Q9LE06 Methionine aminotransferase BCAT4; Branched-chain-amino-acid aminotransferase 4; Atbcat-4; Methionine-oxo-acid transaminase BCAT4; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress)
Q9LE06 branched-chain-amino-acid transaminase (EC 2.6.1.42); methionine transaminase (EC 2.6.1.88) from Arabidopsis thaliana
PFams: Aminotran_4
354 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LPM9 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
356 amino acids: PaperBLAST, CDD, Compare to cluster

Q9M401 branched-chain aminotransferase from Arabidopsis thaliana
BCAT3_ARATH / Q9M401 Branched-chain-amino-acid aminotransferase 3, chloroplastic; Atbcat-3; EC 2.6.1.42; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress)
Q9M401 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
413 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_ARATH / Q9M439 Branched-chain-amino-acid aminotransferase 2, chloroplastic; Atbcat-2; EC 2.6.1.42 from Arabidopsis thaliana (Mouse-ear cress)
Q9M439 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Arabidopsis thaliana
PFams: Aminotran_4
388 amino acids: PaperBLAST, CDD, Compare to cluster

Q9RTX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Deinococcus radiodurans
PFams: Aminotran_4
358 amino acids: PaperBLAST, CDD, Compare to cluster

RF|NP_595180.1 branched chain amino acid aminotransferase Eca39; EC 2.6.1.42 from Schizosaccharomyces pombe
PFams: Aminotran_4
380 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_HUMLU / K7QHS5 Branched-chain amino acid aminotransferase 2, chloroplastic; HlBCAT2; EC 2.6.1.42 from Humulus lupulus (European hop)
PFams: Aminotran_4
408 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT1_HUMLU / K7QKH1 Branched-chain amino acid aminotransferase 1, mitochondrial; HlBCAT1; EC 2.6.1.42 from Humulus lupulus (European hop)
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

BCA1_SCHPO / O14370 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT; EC 2.6.1.42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
O14370 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Schizosaccharomyces pombe
PFams: Aminotran_4
427 amino acids: PaperBLAST, CDD, Compare to cluster

ILVE1_BACSU / O31461 Branched-chain-amino-acid transaminase 1; BCAT 1; EC 2.6.1.42 from Bacillus subtilis (strain 168)
PFams: Aminotran_4
356 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT2_RAT / O35854 Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT(m); EC 2.6.1.42 from Rattus norvegicus (Rat)
PFams: Aminotran_4
393 amino acids: PaperBLAST, CDD, Compare to cluster

ILVE2_BACSU / P39576 Branched-chain-amino-acid aminotransferase 2; BCAT 2; Vegetative protein 85; VEG85; EC 2.6.1.42 from Bacillus subtilis (strain 168)
PFams: Aminotran_4
363 amino acids: PaperBLAST, CDD, Compare to cluster

ATNH_EMENI / Q5AV02 Branched-chain-amino-acid aminotransferase atnH; Aspercryptin biosynthesis cluster protein H; EC 2.6.1.- (from HMM only) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Aminotran_4
396 amino acids: PaperBLAST, CDD, Compare to cluster

BCAT1_SHEEP / Q9GKM4 Branched-chain-amino-acid aminotransferase, cytosolic; BCAT(c); EC 2.6.1.42 from Ovis aries (Sheep)
Q9GKM4 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Ovis aries
PFams: Aminotran_4
385 amino acids: PaperBLAST, CDD, Compare to cluster

GLOG_GLAL2 / S3DQP8 Branched-chain amino acid aminotransferase gloG; L-homotyrosine biosynthesis sub-cluster protein gloG; Pneumocandin biosynthesis cluster protein G; EC 2.6.1.42 from Glarea lozoyensis (strain ATCC 20868 / MF5171)
PFams: Aminotran_4
358 amino acids: PaperBLAST, CDD, Compare to cluster

O86428 branched-chain-amino-acid aminotransferase subunit (EC 2.6.1.6; EC 2.6.1.42) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Aminotran_4
307 amino acids: PaperBLAST, CDD, Compare to cluster

O27481 branched-chain-amino-acid aminotransferase subunit (EC 2.6.1.42) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
PFams: Aminotran_4
306 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS16285 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Burkholderia phytofirmans PsJN
PFams: Aminotran_4
307 amino acids: PaperBLAST, CDD, Compare to cluster

RR42_RS25890 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Cupriavidus basilensis 4G11
PFams: Aminotran_4
363 amino acids: PaperBLAST, CDD, Compare to cluster

N515DRAFT_2015 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Dyella japonica UNC79MFTsu3.2
PFams: Aminotran_4
305 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_0450 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Pseudomonas stutzeri RCH2
PFams: Aminotran_4
307 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_22970 Branched-chain amino acid aminotransferase (EC 2.6.1.42) from Pseudomonas fluorescens FW300-N2C3
PFams: Aminotran_4
339 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 393-417 amino acids (not heteromeric)

A0A060PQX5 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermococcus sp.
PFams: Aminotran_1_2, Aminotran_MocR
417 amino acids: PaperBLAST, CDD, Compare to cluster

BWI76_RS24235 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Klebsiella michiganensis M5al
PFams: Aminotran_1_2, Aminotran_MocR
393 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_1358 L-leucine transaminase; L-isoleucine transaminase (EC 2.6.1.42) from Acidovorax sp. GW101-3H11
PFams: Aminotran_1_2, Aminotran_MocR
401 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS06555 Branched-chain-amino-acid transaminase (EC 2.6.1.42) from Azospirillum brasilense Sp245
PFams: Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_MocR
404 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 286-305 amino acids (not heteromeric)

F2L0W0 branched-chain-amino-acid transaminase (EC 2.6.1.42) from Thermoproteus uzoniensis
PFams: Aminotran_4
295 amino acids: PaperBLAST, CDD, Compare to cluster

P54691 branched-chain-amino-acid transaminase (EC 2.6.1.42); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Synechocystis sp.
PFams: Aminotran_4
305 amino acids: PaperBLAST, CDD, Compare to cluster

GB|AAU18968.1 branched-chain amino acid aminotransferase 2; EC 2.6.1.42 from Bacillus cereus E33L
PFams: Aminotran_4
298 amino acids: PaperBLAST, CDD, Compare to cluster

A6UWA0 branched-chain amino acid aminotransferase subunit (EC 2.6.1.6; EC 2.6.1.42) from Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
PFams: Aminotran_4
286 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

Q9S7N2 tryptophan aminotransferase (EC 2.6.1.1; EC 2.6.1.58; EC 2.6.1.2; EC 2.6.1.6; EC 2.6.1.27; EC 2.6.1.99) from Arabidopsis thaliana
TAA1_ARATH / Q9S7N2 L-tryptophan--pyruvate aminotransferase 1; Protein CYTOKININ INDUCED ROOT CURLING 1; Protein SHADE AVOIDANCE 3; Protein TRANSPORT INHIBITOR RESPONSE 2; Protein TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS 1; Protein WEAK ETHYLENE INSENSITIVE 8; Tryptophan transaminase; EC 2.6.1.27; EC 2.6.1.99 from Arabidopsis thaliana (Mouse-ear cress)
Q9S7N2 tryptophan transaminase (EC 2.6.1.27); L-tryptophan-pyruvate aminotransferase (EC 2.6.1.99) from Arabidopsis thaliana
PFams: Alliinase_C, Aminotran_1_2
391 amino acids: PaperBLAST, CDD

b4054 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.42; EC 2.6.1.27; EC 2.6.1.5; EC 2.6.1.1) from Escherichia coli K-12 substr. MG1655
P04693 tyrosine aminotransferase (EC 2.6.1.57; EC 2.6.1.6; EC 2.6.1.27; EC 2.6.1.1) from Escherichia coli (strain K12)
TYRB_ECOLI / P04693 Aromatic-amino-acid aminotransferase; ARAT; AROAT; Beta-methylphenylalanine transaminase; EC 2.6.1.57; EC 2.6.1.107 from Escherichia coli (strain K12)
GB|AAC77024.1 aromatic-amino-acid transaminase TyrB; EC 2.6.1.57 from Escherichia coli K12
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD

TOXF_COCCA / Q9Y885 Putative branched-chain-amino-acid aminotransferase TOXF; EC 2.6.1.42 from Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola)
PFams: Aminotran_4
357 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q0E9S8 from Cluster 1, but similarity to seed sequence is below thresholds)