Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for dapA (4-hydroxy-tetrahydrodipicolinate synthase) in L-lysine biosynthesis

Or see other characterized proteins similar to dapA

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of dapA

Curated proteins or TIGRFams with EC 4.3.3.7
Curated proteins or TIGRFams with EC 4.2.1.52
Ignore hits to Q3MFY8 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to Q3M723 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8))
Ignore hits to A9CGZ4 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to A9CHR2 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to A9CL94 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to A9CL97 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to Q7D0E8 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to Q7D313 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Ignore hits to Q8A3Z0 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
Comment: Q3MFY8, Q3M723, and many proteins form Agrobacterium tumefaciens are misannotated in BRENDA, and are ignored. (The reference for those points at gene 1133062 = Atu1024 as the synthase instead, and states that the other Agrobacterium dapA-like proteins lack this activity, see PMID:24677246.) Q8A3Z0 is annotated as this in BRENDA, but the cited paper does not demonstrate this activity, and another protein (BT0895) appears to be the major dapA in Bacteroides thetaiotaomicron, (it is essentail), so Q8A3Z0 is ignored.

Fetched 23 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 23 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 289-365 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

CH_021853 dihydrodipicolinate synthase; EC 4.2.1.52 from Bacillus anthracis
PFams: DHDPS
292 amino acids: PaperBLAST, CDD, Compare to cluster

A5F699 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Vibrio cholerae
PFams: DHDPS
292 amino acids: PaperBLAST, CDD, Compare to cluster

A9CFV4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens
PFams: DHDPS
303 amino acids: PaperBLAST, CDD, Compare to cluster

O67216 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Aquifex aeolicus
PFams: DHDPS
294 amino acids: PaperBLAST, CDD, Compare to cluster

b2478 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli K-12 substr. MG1655
P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli (strain K12)
DAPA_ECOLI / P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Escherichia coli (strain K12)
P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Escherichia coli
PFams: DHDPS
292 amino acids: PaperBLAST, CDD, Compare to cluster

P19808 dihydropicolinate synthase subunit (EC 4.3.3.7) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
P19808 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Corynebacterium glutamicum
PFams: DHDPS
301 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_STAAC / Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain COL)
Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Staphylococcus aureus
PFams: DHDPS
295 amino acids: PaperBLAST, CDD, Compare to cluster

Q6G468 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bartonella henselae
PFams: DHDPS
294 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_STAAR / Q6GH13 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain MRSA252)
Q6GH13 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Staphylococcus aureus
PFams: DHDPS
295 amino acids: PaperBLAST, CDD, Compare to cluster

Q7CU96 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens
PFams: DHDPS
298 amino acids: PaperBLAST, CDD, Compare to cluster

Q7D3Z9 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens
PFams: DHDPS
297 amino acids: PaperBLAST, CDD, Compare to cluster

Q8RBI5 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Caldanaerobacter subterraneus subsp. tengcongensis
PFams: DHDPS
297 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_AGRFC / Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Agrobacterium tumefaciens
PFams: DHDPS
294 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FVC8 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Arabidopsis thaliana
PFams: DHDPS
365 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_PSEAE / Q9I4W3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q9I4W3 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Pseudomonas aeruginosa
PFams: DHDPS
292 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_MYCTU / P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: DHDPS
300 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_RHIML / Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Q07607 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Sinorhizobium meliloti
PFams: DHDPS
292 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_METJA / Q57695 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: DHDPS
289 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_NEIMB / Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Neisseria meningitidis serogroup B (strain MC58)
Q9JZR4 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Neisseria meningitidis
PFams: DHDPS
291 amino acids: PaperBLAST, CDD, Compare to cluster

DAPA_THEMA / Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: DHDPS
294 amino acids: PaperBLAST, CDD, Compare to cluster

Q04796 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacillus subtilis (strain 168)
PFams: DHDPS
290 amino acids: PaperBLAST, CDD, Compare to cluster

Q65JG7 dihydrodipicolinate synthase subunit (EC 4.3.3.7) from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)
PFams: DHDPS
289 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

P24846 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Triticum aestivum
PFams: DHDPS
388 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q9FVC8 from Cluster 1, but similarity to seed sequence is below thresholds)