Clusters of Characterized Proteins

Clustering the characterized proteins for dapB (4-hydroxy-tetrahydrodipicolinate reductase) in L-lysine biosynthesis

Or see other characterized proteins similar to dapB

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of dapB

• Curated proteins or TIGRFams with EC 1.17.1.8
• UniProt sequence L0G028_ECHVK: SubName: Full=Dihydrodipicolinate reductase {ECO:0000313|EMBL:AGA78643.1};
• UniProt sequence A0A1X9Z7Q6_9SPHI: RecName: Full=4-hydroxy-tetrahydrodipicolinate reductase {ECO:0000256|HAMAP-Rule:MF_00102}; Short=HTPA reductase {ECO:0000256|HAMAP-Rule:MF_00102}; EC=1.17.1.8 {ECO:0000256|HAMAP-Rule:MF_00102};
• Curated sequence Q3MFY8: 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)
• Ignore hits to Q3M723 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8))
• Comment: Formerly known as dihydrodipicolinate reductase. Echvi_2395 (L0G028_ECHVK) and CA265_RS15670 (A0A1X9Z7Q6_9SPHI) are somewhat diverged, but conserved essentiality confirms they are dapB. Q3MFY8 is misannotated in BRENDA, so it is added manually. Q3M723 is misannotated in BRENDA, so it is ignored.

Fetched 19 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 19 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 216-278 amino acids (not heteromeric)

DvMF_0450 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Desulfovibrio vulgaris Miyazaki F
PFams: DapB_N, DapB_C
259 amino acids: PaperBLAST, CDD, Compare to cluster

P9WP23 dihydropicolinate reductase subunit (EC 1.17.1.8) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
DAPB_MYCTU / P9WP23 4-hydroxy-tetrahydrodipicolinate reductase; HTPA reductase; EC 1.17.1.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WP23 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Mycobacterium tuberculosis
PFams: DapB_N, DapB_C
245 amino acids: PaperBLAST, CDD, Compare to cluster

Q2YJN7 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Brucella abortus
PFams: DapB_N, DapB_C
268 amino acids: PaperBLAST, CDD, Compare to cluster

Q3MFY8 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Trichormus variabilis
PFams: DapB_N, DapB_C
278 amino acids: PaperBLAST, CDD, Compare to cluster

Q5HG24 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Staphylococcus aureus
PFams: DapB_N, DapB_C
240 amino acids: PaperBLAST, CDD, Compare to cluster

Q6G2G3 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Bartonella henselae
PFams: DapB_N, DapB_C
267 amino acids: PaperBLAST, CDD, Compare to cluster

Q9K1F1 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Neisseria meningitidis
PFams: DapB_N, DapB_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

b0031 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Escherichia coli K-12 substr. MG1655
P04036 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Escherichia coli (strain K12)
DAPB_ECOLI / P04036 4-hydroxy-tetrahydrodipicolinate reductase; HTPA reductase; EC 1.17.1.8 from Escherichia coli (strain K12)
GB|BAB96600.1 dihydrodipicolinate reductase; EC 1.3.1.26 from Escherichia coli K12
PFams: DapB_N, DapB_C
273 amino acids: PaperBLAST, CDD, Compare to cluster

DAPB_THEMA / Q9X1K8 4-hydroxy-tetrahydrodipicolinate reductase; HTPA reductase; EC 1.17.1.8 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: DapB_N, DapB_C
216 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9Z7Q6_9SPHI 4-hydroxy-tetrahydrodipicolinate reductase {ECO:0000256|HAMAP-Rule:MF_00102}; Short=HTPA reductase {ECO:0000256|HAMAP-Rule:MF_00102}; EC=1.17.1.8 {ECO:0000256|HAMAP-Rule:MF_00102}
244 amino acids: PaperBLAST, CDD, Compare to cluster

L0G028_ECHVK Dihydrodipicolinate reductase
240 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_2395 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: DapB_N, DapB_C
240 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS15670 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Pedobacter sp. GW460-11-11-14-LB5
PFams: DapB_N, DapB_C
244 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 288-349 amino acids (not heteromeric)

D8R6G2 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Selaginella moellendorffii
PFams: DapB_N, DapB_C
288 amino acids: PaperBLAST, CDD, Compare to cluster

F6HB41 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Vitis vinifera
PFams: DapB_N, DapB_C
349 amino acids: PaperBLAST, CDD, Compare to cluster

Q8LB01 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Arabidopsis thaliana
PFams: DapB_N, DapB_C
349 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 248-267 amino acids (not heteromeric)

P40110 dihydropicolinate reductase subunit (EC 1.17.1.8) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
P40110 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Corynebacterium glutamicum
PFams: DapB_N, DapB_C
248 amino acids: PaperBLAST, CDD, Compare to cluster

P42976 dihydrodipicolinate reductase subunit (EC 1.17.1.8) from Bacillus subtilis (strain 168)
PFams: DapB_N, DapB_C
267 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

DAPB3_ARATH / Q9FJ82 Dihydrodipicolinate reductase-like protein CRR1, chloroplastic; 4-hydroxy-tetrahydrodipicolinate reductase 3; HTPA reductase 3; Protein CHLORORESPIRATORY REDUCTION 1 (from HMM only) from Arabidopsis thaliana (Mouse-ear cress)
PFams: DapB_N, DapB_C
298 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q3MFY8 from Cluster 1, but similarity to seed sequence is below thresholds)