Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for dapC (N-succinyldiaminopimelate aminotransferase) in L-lysine biosynthesis

Or see other characterized proteins similar to dapC

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of dapC

Curated proteins or TIGRFams with EC 2.6.1.17
Curated proteins or TIGRFams with EC 2.6.1.52
Ignore hits to O50434 when looking for 'other' hits (Probable aminotransferase Rv1178; EC 2.6.1.-)
Ignore hits to items matching EC 2.6.1.81 when looking for 'other' hits
Comment: 2.6.1.52 is the EC number for 3-phosphoserine aminotransferase (serC), which catalyzes this reaction in E. coli. The function of O50434 is not known, so similarity to it is ignored. E.coli's succinylornithine transaminase has this activity as well (PMID:25243376), so similarity to succinylornithine transaminases (EC 2.6.1.81) is ignored.

Fetched 26 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 24 of these sequences

Found 5 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 361-430 amino acids (not heteromeric)

b0907 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli K-12 substr. MG1655
P23721 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli (strain K12)
SERC_ECOLI / P23721 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Escherichia coli (strain K12)
P23721 phosphoserine transaminase (EC 2.6.1.52) from Escherichia coli
CH_002572 phosphoserine aminotransferase; EC 2.6.1.52 from Escherichia coli K12
PFams: Aminotran_5
362 amino acids: PaperBLAST, CDD, Compare to cluster

Q2F5M8 phosphoserine transaminase (EC 2.6.1.52) from Bombyx mori
PFams: Aminotran_5
364 amino acids: PaperBLAST, CDD, Compare to cluster

Q96255 phosphoserine aminotransferase (EC 2.6.1.52) from Arabidopsis thaliana
SERB1_ARATH / Q96255 Phosphoserine aminotransferase 1, chloroplastic; AtPSAT1; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress)
Q96255 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana
PFams: Aminotran_5
430 amino acids: PaperBLAST, CDD, Compare to cluster

SERB2_ARATH / Q9SHP0 Phosphoserine aminotransferase 2, chloroplastic; AtPSAT2; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress)
Q9SHP0 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana
PFams: Aminotran_5
422 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Y617 Phosphoserine aminotransferase (EC 2.6.1.52) from Homo sapiens
SERC_HUMAN / Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human)
Q9Y617 glycine transaminase (EC 2.6.1.4); phosphoserine transaminase (EC 2.6.1.52) from Homo sapiens
PFams: Aminotran_5
370 amino acids: PaperBLAST, CDD, Compare to cluster

V9NC98 phosphoserine transaminase (EC 2.6.1.52) from Acanthamoeba castellanii
PFams: Aminotran_5
394 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_RABIT / P10658 Phosphoserine aminotransferase; PSAT; Endometrial progesterone-induced protein; EPIP; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Oryctolagus cuniculus (Rabbit)
PFams: Aminotran_5
370 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_YEAST / P33330 Phosphoserine aminotransferase; PSAT; Phosphohydroxythreonine aminotransferase; Serine requiring protein 1; EC 2.6.1.52 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Aminotran_5
395 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_SPIOL / P52877 Phosphoserine aminotransferase, chloroplastic; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Spinacia oleracea (Spinach)
PFams: Aminotran_5
430 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_NIACI / Q59196 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Niallia circulans (Bacillus circulans)
Q59196 phosphoserine transaminase (EC 2.6.1.52) from Niallia circulans
PFams: Aminotran_5
362 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_ALKAL / Q9RME2 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Alkalihalobacillus alcalophilus (Bacillus alcalophilus)
Q9RME2 phosphoserine transaminase (EC 2.6.1.52) from Alkalihalobacillus alcalophilus
PFams: Aminotran_5
361 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_DROME / Q9VAN0 Probable phosphoserine aminotransferase; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Drosophila melanogaster (Fruit fly)
PFams: Aminotran_5
364 amino acids: PaperBLAST, CDD, Compare to cluster

A2FXW5 phosphoserine transaminase (EC 2.6.1.52) from Trichomonas vaginalis (strain ATCC PRA-98 / G3)
PFams: Aminotran_5
371 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 359-397 amino acids (not heteromeric)

Q82IK5 succinyldiaminopimelate transaminase (EC 2.6.1.17); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Streptomyces avermitilis
PFams: Aminotran_1_2
364 amino acids: PaperBLAST, CDD, Compare to cluster

Q8NRE6 succinyldiaminopimelate transaminase (EC 2.6.1.17) from Corynebacterium glutamicum
PFams: Aminotran_1_2
367 amino acids: PaperBLAST, CDD, Compare to cluster

L8EVF8 4-dedimethylamino-4-oxo-anhydrotetracycline transaminase (from HMM only) from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234)
OXYQ_STRRM / Q3S8P9 4-dedimethylamino-4-oxo-anhydrotetracycline transaminase OxyQ; PLP-dependent aminotransferase OxyQ; Reductive transaminase oxyQ; EC 2.6.1.- from Streptomyces rimosus
PFams: Aminotran_1_2
359 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZEX3 N-succinyldiaminopimelate-aminotransferase (EC 2.6.1.17) from Bordetella pertussis
Q9ZEX3 succinyldiaminopimelate transaminase (EC 2.6.1.17) from Bordetella pertussis
PFams: Aminotran_1_2
397 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 389-406 amino acids (not heteromeric)

b3359 N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (EC 2.6.1.11; EC 2.6.1.17) from Escherichia coli K-12 substr. MG1655
P18335 N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (EC 2.6.1.11; EC 2.6.1.17) from Escherichia coli (strain K12)
ARGD_ECOLI / P18335 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Escherichia coli (strain K12)
PFams: Aminotran_3, Aminotran_1_2
406 amino acids: PaperBLAST, CDD, Compare to cluster

ARGD_SALTY / P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aminotran_3, Aminotran_1_2
405 amino acids: PaperBLAST, CDD, Compare to cluster

AZOBR_RS19025 acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] from Azospirillum brasilense Sp245
PFams: Aminotran_3
389 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 384-385 amino acids (not heteromeric)

P74281 serine—glyoxylate transaminase (EC 2.6.1.52) from Synechocystis sp. (strain PCC 6803 / Kazusa)
P74281 phosphoserine transaminase (EC 2.6.1.52) from Synechocystis sp.
PFams: Aminotran_5
384 amino acids: PaperBLAST, CDD, Compare to cluster

Q58369 phosphoserine aminotransferase monomer (EC 2.6.1.1; EC 2.6.1.52) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
PFams: Aminotran_5
385 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 370-370 amino acids (not heteromeric)

SERC_METBF / P52878 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Methanosarcina barkeri (strain Fusaro / DSM 804)
P52878 phosphoserine transaminase (EC 2.6.1.52) from Methanosarcina barkeri
370 amino acids: PaperBLAST, CDD, Compare to cluster

Q8TNI1 phosphoserine aminotransferase monomer (EC 2.6.1.52; EC 2.6.1.1) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
370 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

DAPC_MYCTU / P9WPZ5 Probable N-succinyldiaminopimelate aminotransferase DapC; DAP-AT; EC 2.6.1.17 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WPZ5 succinyldiaminopimelate transaminase (EC 2.6.1.17) from Mycobacterium tuberculosis
PFams: Aminotran_1_2, Aminotran_5
397 amino acids: PaperBLAST, CDD

SERC_MYCTU / P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WQ73 phosphoserine transaminase (EC 2.6.1.52) from Mycobacterium tuberculosis
PFams: Aminotran_5
376 amino acids: PaperBLAST, CDD