Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for dapF (diaminopimelate epimerase) in L-lysine biosynthesis

Or see other characterized proteins similar to dapF

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of dapF

Curated proteins or TIGRFams with EC 5.1.1.7
Predicted: UniProt sequence A0A9Q5JK70: SubName: Full=Alanine racemase {ECO:0000313|EMBL:OFQ71504.1};
Comment: L,L-diaminopimelate to meso-diaminopimelate. A putative amino acid racemase (A0A9Q5JK70) is in a conserved operon with lysA ("dapF2" in PMC9026213); it is likely to be a diaminopimelate epimerase.

Fetched 10 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 9 of these sequences

Found 1 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 274-362 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

E4NI20 diaminopimelate epimerase (EC 5.1.1.7) from Kitasatospora setae
PFams: DAP_epimerase, DAP_epimerase
295 amino acids: PaperBLAST, CDD, Compare to cluster

DAPF_MYCTU / P9WP19 Diaminopimelate epimerase; DAP epimerase; PLP-independent amino acid racemase; EC 5.1.1.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WP19 diaminopimelate epimerase (EC 5.1.1.7) from Mycobacterium tuberculosis
PFams: DAP_epimerase, DAP_epimerase
289 amino acids: PaperBLAST, CDD, Compare to cluster

DAPF_CORGL / Q8NP73 Diaminopimelate epimerase; DAP epimerase; PLP-independent amino acid racemase; EC 5.1.1.7 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Q8NP73 diaminopimelate epimerase (EC 5.1.1.7) from Corynebacterium glutamicum
PFams: DAP_epimerase, DAP_epimerase
277 amino acids: PaperBLAST, CDD, Compare to cluster

DAPF_ARATH / Q9LFG2 Diaminopimelate epimerase, chloroplastic; DAP epimerase; EC 5.1.1.7 from Arabidopsis thaliana (Mouse-ear cress)
Q9LFG2 diaminopimelate epimerase (EC 5.1.1.7) from Arabidopsis thaliana
PFams: DAP_epimerase, DAP_epimerase
362 amino acids: PaperBLAST, CDD, Compare to cluster

D2Z026 O-ureido-serine racemase (EC 5.1.1.19) (from HMM only) from Streptomyces lavendulae
DCSC_STRLA / D2Z026 O-ureido-serine racemase; EC 5.1.1.19 from Streptomyces lavendulae
D2Z026 O-ureido-serine racemase (EC 5.1.1.19) from Streptomyces lavendulae subsp. lavendulae
PFams: DAP_epimerase, DAP_epimerase
287 amino acids: PaperBLAST, CDD, Compare to cluster

b3809 diaminopimelate epimerase (EC 5.1.1.7) from Escherichia coli K-12 substr. MG1655
P0A6K1 diaminopimelate epimerase (EC 5.1.1.7) from Escherichia coli (strain K12)
DAPF_ECOLI / P0A6K1 Diaminopimelate epimerase; DAP epimerase; PLP-independent amino acid racemase; EC 5.1.1.7 from Escherichia coli (strain K12)
PFams: DAP_epimerase, DAP_epimerase
274 amino acids: PaperBLAST, CDD, Compare to cluster

DAPF_HAEIN / P44859 Diaminopimelate epimerase; DAP epimerase; PLP-independent amino acid racemase; EC 5.1.1.7 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
PFams: DAP_epimerase, DAP_epimerase
274 amino acids: PaperBLAST, CDD, Compare to cluster

DAPF_BACAN / Q81XR2 Diaminopimelate epimerase; DAP epimerase; PLP-independent amino acid racemase; EC 5.1.1.7 from Bacillus anthracis
PFams: DAP_epimerase, DAP_epimerase
288 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

DAPF_THEMA / Q9X1L0 Diaminopimelate epimerase; DAP epimerase; Dpm epimerase; PLP-independent amino acid racemase; EC 5.1.1.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: DAP_epimerase, DAP_epimerase
236 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q8NP73 from Cluster 1, but similarity to seed sequence is below thresholds)

A0A9Q5JK70 Alanine racemase
357 amino acids: PaperBLAST, CDD