Clusters of Characterized Proteins

Clustering the characterized proteins for lysK ([LysW]-lysine hydrolase) in L-lysine biosynthesis

Or see other characterized proteins similar to lysK

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Definition of lysK

• Curated proteins or TIGRFams with EC 3.5.1.130
• UniProt sequence Q5JFW4: RecName: Full=Putative [LysW]-lysine/[LysW]-ornithine hydrolase {ECO:0000255|HAMAP-Rule:MF_01120}; EC=3.5.1.130 {ECO:0000255|HAMAP-Rule:MF_01120}; EC=3.5.1.132 {ECO:0000255|HAMAP-Rule:MF_01120};
• Comment: TK0274 from Thermococcus kodakarensis (Q5JFW4) is bifunctional, for lysine and ornithine synthesis (PMC5076833).

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 344-361 amino acids (not heteromeric)

Q5JFW4 Putative [LysW]-lysine/[LysW]-ornithine hydrolase {ECO:0000255|HAMAP-Rule:MF_01120}; EC=3.5.1.130 {ECO:0000255|HAMAP-Rule:MF_01120}; EC=3.5.1.132 {ECO:0000255|HAMAP-Rule:MF_01120}
344 amino acids: PaperBLAST, CDD, Compare to cluster

Q8VUS5 [L-2-aminoadipate carrier protein]-L-lysine lysine-hydrolase monomer (EC 3.5.1.130) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
LYSK_THET2 / Q8VUS5 [LysW]-lysine hydrolase; EC 3.5.1.130 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q8VUS5 [amino group carrier protein]-lysine hydrolase (EC 3.5.1.130) from Thermus thermophilus
PFams: Peptidase_M20
361 amino acids: PaperBLAST, CDD, Compare to cluster

Q4JAP7 [amino group carrier protein]-lysine/ornithine hydrolase (EC 3.5.1.130; EC 3.5.1.132) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
PFams: Peptidase_M20, M20_dimer
346 amino acids: PaperBLAST, CDD, Compare to cluster