Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for lysN (2-aminoadipate:2-oxoglutarate aminotransferase) in L-lysine biosynthesis

Or see other characterized proteins similar to lysN

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of lysN

Curated proteins or TIGRFams with EC 2.6.1.39
Ignore hits to Q06191 when looking for 'other' hits (Aspartate aminotransferase; AAT; AspAT; Transaminase A; EC 2.6.1.1)
Comment: 2-oxoadipate to 2-aminoadipate. Q06191 is very simlar to SMc04386, which seems to have this activity (it is required for lysine utilization), and as far as we know, Q06191 has not been tested for activity on 2-aminoadipate, so it is ignored

Fetched 9 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 2 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 425-491 amino acids (not heteromeric)

Q64602 α-aminoadipate aminotransferase subunit (EC 2.6.1.39) from Rattus norvegicus
AADAT_RAT / Q64602 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Rattus norvegicus (Rat)
Q64602 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Rattus norvegicus
PFams: Aminotran_1_2
425 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D8PG20 2-aminoadipate transaminase (EC 2.6.1.39); aromatic-amino-acid transaminase (EC 2.6.1.57) from Candida albicans
PFams: Aminotran_1_2
491 amino acids: PaperBLAST, CDD, Compare to cluster

Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (EC 2.6.1.7; EC 2.6.1.39) from Homo sapiens
AADAT_HUMAN / Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Homo sapiens (Human)
Q8N5Z0 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Homo sapiens
PFams: Aminotran_1_2, Asp_aminotransf
425 amino acids: PaperBLAST, CDD, Compare to cluster

AADAT_MOUSE / Q9WVM8 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Mus musculus (Mouse)
Q9WVM8 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Mus musculus
PFams: Aminotran_1_2
425 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 397-397 amino acids (not heteromeric)

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus
PFams: Aminotran_1_2, Asp_aminotransf
397 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: Aminotran_1_2, Asp_aminotransf
397 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

P53090 aromatic amino acid/aminoadipate aminotransferase monomer (EC 2.6.1.39; EC 2.6.1.1; EC 2.6.1.28) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ARO8_YEAST / P53090 Aromatic/aminoadipate aminotransferase 1; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Aromatic amino acid aminotransferase 1; Aromatic amino acid aminotransferase I; Aromatic amino acid-requiring protein 8; EC 2.6.1.39; EC 2.6.1.57 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P53090 2-aminoadipate transaminase (EC 2.6.1.39); aromatic-amino-acid transaminase (EC 2.6.1.57) from Saccharomyces cerevisiae
PFams: Aminotran_1_2
500 amino acids: PaperBLAST, CDD
(similar to BRENDA::A0A1D8PG20 from Cluster 1, but similarity to seed sequence is below thresholds)

SMc04386 2-aminoadipate:2-oxoglutarate aminotransferase (EC 2.6.1.39) from Sinorhizobium meliloti 1021
AAT_RHIME / P58350 Aspartate aminotransferase; AAT; AspAT; Putative 2-aminoadipate transaminase; Transaminase A; EC 2.6.1.1; EC 2.6.1.39 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
PFams: Aminotran_1_2, DegT_DnrJ_EryC1
410 amino acids: PaperBLAST, CDD

PP_4108 2-aminoadipate transaminase (EC 2.6.1.39) from Pseudomonas putida KT2440
Q88FI7 4-aminobutyrate aminotransferase (EC 2.6.1.39) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
2AAAT_PSEPK / Q88FI7 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; L-2AA aminotransferase; EC 2.6.1.39 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
PFams: Aminotran_3
416 amino acids: PaperBLAST, CDD