Clusters of Characterized Proteins

Clustering the characterized proteins for lysX (2-aminoadipate-LysW ligase) in L-lysine biosynthesis

Or see other characterized proteins similar to lysX

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of lysX

• Curated proteins or TIGRFams with EC 6.3.2.43
• Ignore hits to A5U2Z7 when looking for 'other' hits ([amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43). lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43). Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX; EC 6.1.1.6; EC 2.3.2.3)
• Ignore hits to P9WFU7 when looking for 'other' hits ([amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43). lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43). Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX; EC 6.1.1.6; EC 2.3.2.3)
• UniProt sequence Q5JFW0: SubName: Full=RimK-related lysine biosynthesis protein {ECO:0000313|EMBL:BAD84467.1};
• Comment: A5U2Z7 and BRENDA::P9WFU7 are misannotated in BRENDA. TK0278 from Thermococcus kodakarensis (Q5JFW0) is bifunctional, for lysine and ornithine synthesis (PMC5076833).

Fetched 5 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 273-280 amino acids (not heteromeric)

LYSX_SULAC / Q4JAP9 Alpha-aminoadipate--LysW ligase LysX; AAA--LysW ligase LysX; EC 6.3.2.43 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Q4JAP9 [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Sulfolobus acidocaldarius
PFams: RimK, CPSase_L_D2
276 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JFW0 lysyltransferase (EC 2.3.2.3); [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43); glutamate---[amino group carrier protein] ligase (EC 6.3.2.60) from Thermococcus kodakarensis
PFams: RimK
273 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SH23 L-2-aminoadipate--LysW ligase monomer (EC 6.3.2.43) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
LYSX_THET8 / Q5SH23 Alpha-aminoadipate--LysW ligase LysX; AAA--LysW ligase LysX; EC 6.3.2.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q5SH23 [amino group carrier protein]-L-2-aminoadipate ligase (EC 6.3.2.43) from Thermus thermophilus
PFams: ATP-grasp_3, CPSase_L_D2, RimK, GSH-S_ATP
280 amino acids: PaperBLAST, CDD, Compare to cluster

LYSX_SACS2 / Q7SI95 Alpha-aminoadipate--LysW ligase LysX; AAA--LysW ligase LysX; EC 6.3.2.43 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
PFams: RimK, CPSase_L_D2, GSH-S_ATP
275 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JFW0 RimK-related lysine biosynthesis protein
273 amino acids: PaperBLAST, CDD, Compare to cluster