Clusters of Characterized Proteins

Clustering the characterized proteins for amaB (L-2-aminoadipate semialdehyde dehydrogenase (AmaB/Pcd)) in L-lysine catabolism

Or see other characterized proteins similar to amaB

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Definition of amaB

• Curated proteins or TIGRFams with EC 1.2.1.31
• Ignore hits to Q4L235 when looking for 'other' hits (Beta-alanine-activating enzyme; Acyl-CoA synthetase family member 4; Protein NRPS998; EC 6.2.1.-. L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31))
• Do not include HMM TIGR03443 (when considering EC numbers)
• Ignore hits to P83402 when looking for 'other' hits (Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31)
• Ignore hits to P84463 when looking for 'other' hits (Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31)
• Curated sequence MONOMER-12387: Δ¹-piperideine-6-carboxylate dehydrogenase
• UniProt sequence Q88CC3: SubName: Full=L-piperidine-6-carboxylate dehydrogenase {ECO:0000313|EMBL:AAN70823.1}; EC=1.2.1.21 {ECO:0000313|EMBL:AAN70823.1};
• UniProt sequence Q92L07: SubName: Full=Putative aldehyde dehydrogenase transmembrane protein {ECO:0000313|EMBL:CAC47869.1}; EC=1.2.1.3 {ECO:0000313|EMBL:CAC47869.1};
• Comment: Q4L235 is misannotated in BRENDA. TIGR03443 hits both amaB and the ATP-hydrolyzing L-2-aminoadipate reductase. P83402 and P84463 are short sequence fragments. In MetaCyc, MONOMER-20455 is annotated as performing this reaction but was not given this EC number. PP_5258 (Q88CC3) is in a newer version of metacyc. SMc04385 (Q92L07) was identified using fitness data.

Fetched 9 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 9 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 496-539 amino acids (not heteromeric)

Q88CC3 L-piperidine-6-carboxylate dehydrogenase; EC=1.2.1.21
496 amino acids: PaperBLAST, CDD, Compare to cluster

P49419 Alpha-aminoadipic semialdehyde dehydrogenase (EC 1.2.1.8; EC 1.2.1.31) from Homo sapiens
AL7A1_HUMAN / P49419 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Homo sapiens (Human)
P49419 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) from Homo sapiens
PFams: Aldedh
539 amino acids: PaperBLAST, CDD, Compare to cluster

AL7A1_RAT / Q64057 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Rattus norvegicus (Rat)
PFams: Aldedh
539 amino acids: PaperBLAST, CDD, Compare to cluster

AL7A1_MOUSE / Q9DBF1 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Mus musculus (Mouse)
Q9DBF1 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) from Mus musculus
PFams: Aldedh
539 amino acids: PaperBLAST, CDD, Compare to cluster

Q92L07 Putative aldehyde dehydrogenase transmembrane protein; EC=1.2.1.3
510 amino acids: PaperBLAST, CDD, Compare to cluster

O54199 Δ¹-piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus
PFams: Aldedh
496 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 1384-1419 amino acids (not heteromeric)

P07702 L-2-aminoadipate reductase (EC 1.2.1.95) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
LYS2_YEAST / P07702 L-2-aminoadipate reductase; Alpha-aminoadipate reductase; Alpha-AR; L-aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31; EC 1.2.1.95 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P07702 L-2-aminoadipate reductase (EC 1.2.1.95) from Saccharomyces cerevisiae
PFams: AMP-binding, PP-binding, Epimerase, NAD_binding_4
1392 amino acids: PaperBLAST, CDD, Compare to cluster

Q8NJ21 L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) from Kluyveromyces lactis
PFams: AMP-binding, PP-binding, Epimerase, 3Beta_HSD, NAD_binding_4
1384 amino acids: PaperBLAST, CDD, Compare to cluster

LYS2_SCHPO / P40976 L-2-aminoadipate reductase; Alpha-aminoadipate reductase; Alpha-AR; L-aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31; EC 1.2.1.95 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
P40976 L-2-aminoadipate reductase (EC 1.2.1.95) from Schizosaccharomyces pombe
RF|NP_594314.1 aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31 from Schizosaccharomyces pombe
PFams: Condensation, AMP-binding, AMP-binding_C, PP-binding, Epimerase, NAD_binding_4
1419 amino acids: PaperBLAST, CDD, Compare to cluster