Clusters of Characterized Proteins

Clustering the characterized proteins for argT (L-lysine ABC transporter, substrate-binding component ArgT) in L-lysine catabolism

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Definition of argT

• Curated sequence CH_003045: lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT. Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein
• Curated sequence P09551: ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1)
• Curated sequence Q9HU31: Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
• Curated sequence AO356_05495: ABC transporter for L-Lysine, periplasmic substrate-binding component
• Curated sequence AO356_09900: ABC transporter for L-Lysine, periplasmic substrate-binding component
• Curated sequence Pf6N2E2_2958: ABC transporter for L-Lysine, periplasmic substrate-binding component
• UniProt sequence Q92PA9: SubName: Full=Putative amino-acid binding periplasmic protein {ECO:0000313|EMBL:CAC46449.1};
• UniProt sequence Q88GX4: SubName: Full=Amino acid ABC transporter, periplasmic binding protein {ECO:0000313|EMBL:AAN69193.1};
• Comment: In E. coli and Salmonella, the ABC transporter has a lysine/arginine specific binding protein (argT), two permease subunits (hisQM, which are similar to each other), and an ATPase subunit (hisP). Pseudomonas aeruginosa has a homologous lysine transporter, PA5152-PA5155, as do various strains of Pseudomonas fluorescens. In P. putida, a similar system was identified using fitness data (argT = PP_3593 = Q88GX4; hisQ = PP_3594 = Q88GX3; hisM = PP_3595 = Q88GX2; hisP = PP_3597 = Q88GX0). In S. meliloti, a similar substrate-binding protein was identified using fitness data (SMc00140 = Q92PA9), but the ATPase subunit was not found (it might be shared with other systems).

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 8 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 250-260 amino acids (5/8 heteromeric)

ARGT_SALTY / P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
RF|NP_461297.1 lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: SBP_bac_3
260 amino acids: PaperBLAST, CDD, Compare to cluster

b2310 lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
TC 3.A.1.3.1 / TC 3.A.1.3.29 / P09551 ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli
PFams: SBP_bac_3
Heteromeric, 260 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.23 / Q9HU31 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 250 amino acids: PaperBLAST, CDD, Compare to cluster

Q88GX4 Amino acid ABC transporter, periplasmic binding protein
250 amino acids: PaperBLAST, CDD, Compare to cluster

Q92PA9 Putative amino-acid binding periplasmic protein
260 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_05495 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
PFams: SBP_bac_3, NMT1
Heteromeric, 260 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_09900 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 251 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_2958 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
PFams: SBP_bac_3, NMT1
Heteromeric, 260 amino acids: PaperBLAST, CDD, Compare to cluster