Clusters of Characterized Proteins

Clustering the characterized proteins for hglS (D-2-hydroxyglutarate synthase) in L-lysine catabolism

Or see other characterized proteins similar to hglS

Or see all steps for L-lysine catabolism

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Definition of hglS

• Curated sequence PP_5260: 2-oxoadipate decarboxylase/hydroxylase (2-hydroxyglutarate synthase)
• Curated sequence AO356_01105: putative hydrolase, required for lysine catabolism
• Curated sequence SMc04383: putative hydrolase, required for lysine catabolism
• Curated sequence G6738-MONOMER: DUF1338 domain-containing protein YdcJ
• Comment: PP_5260 was shown to be form D-2-hydroxyglutarate (link). Homologous proteins that are specifically important for L-lysine utilization are also included. The E. coli homolog (ydcJ, G6738-MONOMER) also has this activity, see PMC7286885.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 447-466 amino acids (not heteromeric)

b1423 DUF1338 domain-containing protein YdcJ from Escherichia coli K-12 substr. MG1655
PFams: DUF1338
447 amino acids: PaperBLAST, CDD, Compare to cluster

PP_5260 2-oxoadipate decarboxylase/hydroxylase (2-hydroxyglutarate synthase) from Pseudomonas putida KT2440
PFams: DUF1338
464 amino acids: PaperBLAST, CDD, Compare to cluster

SMc04383 putative hydrolase, required for lysine catabolism from Sinorhizobium meliloti 1021
PFams: DUF1338
466 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_01105 putative hydrolase, required for lysine catabolism from Pseudomonas fluorescens FW300-N2C3
PFams: DUF1338
458 amino acids: PaperBLAST, CDD, Compare to cluster