Clusters of Characterized Proteins

Clustering the characterized proteins for hisP (L-lysine ABC transporter, ATPase component HisP) in L-lysine catabolism

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Definition of hisP

• Curated sequence CH_003210: histidine transport ATP-binding protein hisP. Histidine transport ATP-binding protein HisP, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. lysine/arginine/ornithine ABC transporter / histidine ABC transporter, ATP binding subunit (EC 7.4.2.1)
• Curated sequence P02915: Histidine transport ATP-binding protein HisP. histidine transport atp-binding protein hisp. HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium
• Curated sequence P73721: BgtA aka SLR1735, component of Arginine/lysine/histidine/glutamine porter
• Curated sequence Q9HU32: Probable ATP-binding component of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
• Curated sequence AO356_05515: ABC transporter for L-Lysine, ATPase component
• Curated sequence AO356_09895: ABC transporter for L-Lysine, ATPase component
• Curated sequence Pf6N2E2_2962: ABC transporter for L-Lysine, ATPase component
• UniProt sequence Q88GX0: SubName: Full=Amino-acid ABC transporter, ATP-binding protein {ECO:0000313|EMBL:AAN69197.1};

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 8 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 252-260 amino acids (7/8 heteromeric)

b2306 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
TC 3.A.1.3.29 / P07109 Histidine transport ATP-binding protein HisP, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
GB|AAC75366.1 histidine transport ATP-binding protein hisP from Escherichia coli K12
PFams: ABC_tran, AAA_21
Heteromeric, 257 amino acids: PaperBLAST, CDD, Compare to cluster

HISP_SALTY / P02915 Histidine transport ATP-binding protein HisP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: ABC_tran, AAA_21
Heteromeric, 258 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.12 / P73721 BgtA aka SLR1735, component of Arginine/lysine/histidine/glutamine porter
PFams: ABC_tran
Heteromeric, 252 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.23 / Q9HU32 Probable ATP-binding component of ABC transporter, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: ABC_tran, AAA_21
Heteromeric, 257 amino acids: PaperBLAST, CDD, Compare to cluster

Q88GX0 Amino-acid ABC transporter, ATP-binding protein
260 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_05515 ABC transporter for L-Lysine, ATPase component from Pseudomonas fluorescens FW300-N2C3
PFams: ABC_tran
Heteromeric, 254 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_09895 ABC transporter for L-Lysine, ATPase component from Pseudomonas fluorescens FW300-N2C3
PFams: ABC_tran, AAA_21
Heteromeric, 257 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_2962 ABC transporter for L-Lysine, ATPase component from Pseudomonas fluorescens FW300-N2E2
PFams: ABC_tran
Heteromeric, 254 amino acids: PaperBLAST, CDD, Compare to cluster