Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for ydiJ ((R)-2-hydroxyglutarate dehydrogenase) in L-lysine catabolism

Or see other characterized proteins similar to ydiJ

Or see all steps for L-lysine catabolism

Or cluster curated proteins matching a keyword

Definition of ydiJ

Curated proteins or TIGRFams with EC 1.1.99.39
Curated proteins or TIGRFams with EC 1.1.99.40
Curated sequence PP_4493: 2-hydroxyglutarate oxidase (EC 1.1.3.15)
UniProt sequence Q92L08: SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:CAC47868.1};
Comment: PP_4493 was misannotated as EC 1.1.3.15, which acts on (S)-2-hydroxyglutarate. The E. coli homolog (ydiJ, link) does not seem to be characterized. SMc04384 (Q92L08) was identified using fitness data.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 473-559 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

D2HDH_ARATH / O23240 D-2-hydroxyglutarate dehydrogenase, mitochondrial; AtD-2HGDH; EC 1.1.99.39 from Arabidopsis thaliana (Mouse-ear cress)
O23240 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Arabidopsis thaliana
PFams: FAD_binding_4, FAD-oxidase_C
559 amino acids: PaperBLAST, CDD, Compare to cluster

DLD3_YEAST / P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P39976 (R)-2-hydroxyglutarate-pyruvate transhydrogenase (EC 1.1.99.40) from Saccharomyces cerevisiae
PFams: FAD_binding_4, FAD-oxidase_C
496 amino acids: PaperBLAST, CDD, Compare to cluster

Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39) from Homo sapiens
D2HDH_HUMAN / Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.- from Homo sapiens (Human)
Q8N465 D-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) from Homo sapiens
PFams: FAD_binding_4, FAD-oxidase_C
521 amino acids: PaperBLAST, CDD, Compare to cluster

DLD2_YEAST / P46681 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2HG--pyruvate transhydrogenase DLD2; Actin-interacting protein 2; D-lactate dehydrogenase [cytochrome] 2, mitochondrial; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: FAD_binding_4, FAD-oxidase_C
530 amino acids: PaperBLAST, CDD, Compare to cluster

Q92L08 Putative oxidoreductase
473 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

PP_4493 2-hydroxyglutarate oxidase (EC 1.1.3.15) from Pseudomonas putida KT2440
PFams: FAD_binding_4, FAD-oxidase_C, Fer4_8
1006 amino acids: PaperBLAST, CDD