GapMind for catabolism of small carbon sources

 

Clusters of Characterized Proteins

Clustering the characterized proteins for manA (mannose-6-phosphate isomerase) in D-mannose catabolism

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Definition of manA

Fetched 29 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 27 of these sequences

Found 4 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 391-461 amino acids (not heteromeric)

Q6H5C7 mannose-6-phosphate isomerase (EC 5.3.1.8) from Oryza sativa Japonica Group
PFams: PMI_typeI
399 amino acids: PaperBLAST, CDD, Compare to cluster

E1ZPT8 mannose-6-phosphate isomerase (EC 5.3.1.8) from Chlorella variabilis
PFams: PMI_typeI
425 amino acids: PaperBLAST, CDD, Compare to cluster

G1E7A7 mannose-6-phosphate isomerase (EC 5.3.1.8) from Brassica rapa subsp. chinensis
PFams: PMI_typeI
444 amino acids: PaperBLAST, CDD, Compare to cluster

P25081 mannose-6-phosphate isomerase (EC 5.3.1.8) from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: PMI_typeI
391 amino acids: PaperBLAST, CDD, Compare to cluster

Q66WM4 mannose-6-phosphate isomerase (EC 5.3.1.8) from Aspergillus fumigatus
PFams: PMI_typeI
457 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FTR6 mannose-6-phosphate isomerase (EC 5.3.1.8) from Oryza sativa Japonica Group
PFams: PMI_typeI
428 amino acids: PaperBLAST, CDD, Compare to cluster

Q9GRS9 mannose-6-phosphate isomerase (EC 5.3.1.8) from Leishmania mexicana
PFams: PMI_typeI
421 amino acids: PaperBLAST, CDD, Compare to cluster

MPI1_ARATH / Q9M884 Mannose-6-phosphate isomerase 1; Phosphohexomutase 1; Phosphomannose isomerase 1; PMI1; Protein MATERNAL EFFECT EMBRYO ARREST 31; EC 5.3.1.8 from Arabidopsis thaliana (Mouse-ear cress)
Q9M884 mannose-6-phosphate isomerase (EC 5.3.1.8) from Arabidopsis thaliana
PFams: PMI_typeI
432 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122571 mannose-6-phosphate isomerase; EC 5.3.1.8 from Emericella nidulans
PFams: PMI_typeI
461 amino acids: PaperBLAST, CDD, Compare to cluster

P34948 mannose-6-phosphate isomerase (EC 5.3.1.8) from Candida albicans
GI|557637 mannose-6-phosphate isomerase; EC 5.3.1.8 from Candida albicans
PFams: PMI_typeI
441 amino acids: PaperBLAST, CDD, Compare to cluster

MPI_SCHPO / O43014 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: PMI_typeI
412 amino acids: PaperBLAST, CDD, Compare to cluster

MPI_YEAST / P29952 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PMI_typeI, AraC_binding
429 amino acids: PaperBLAST, CDD, Compare to cluster

MPI_HUMAN / P34949 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Homo sapiens (Human)
PFams: PMI_typeI
423 amino acids: PaperBLAST, CDD, Compare to cluster

MPI_MOUSE / Q924M7 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Mus musculus (Mouse)
PFams: PMI_typeI
423 amino acids: PaperBLAST, CDD, Compare to cluster

MPI2_ARATH / Q9FZH5 Mannose-6-phosphate isomerase 2; Phosphohexomutase 2; Phosphomannose isomerase 2; PMI2; Protein DARK INDUCIBLE 9; EC 5.3.1.8 from Arabidopsis thaliana (Mouse-ear cress)
PFams: PMI_typeI
441 amino acids: PaperBLAST, CDD, Compare to cluster

b1613 mannose-6-phosphate isomerase (EC 5.3.1.8) from Escherichia coli K-12 substr. MG1655
P00946 mannose-6-phosphate isomerase (EC 5.3.1.8) from Escherichia coli (strain K12)
PFams: PMI_typeI
391 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 315-320 amino acids (not heteromeric)

A4ITT1 mannose-6-phosphate isomerase (EC 5.3.1.8) from Geobacillus thermodenitrificans
PFams: PMI_typeI
320 amino acids: PaperBLAST, CDD, Compare to cluster

Q9AGZ4 mannose-6-phosphate isomerase (EC 5.3.1.8) from Bacillus subtilis
PFams: PMI_typeI
315 amino acids: PaperBLAST, CDD, Compare to cluster

MANA2_BACSU / O05511 Probable mannose-6-phosphate isomerase GmuF; Glucomannan utilization protein F; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Bacillus subtilis (strain 168)
PFams: PMI_typeI
315 amino acids: PaperBLAST, CDD, Compare to cluster

MANA1_BACSU / O31646 Mannose-6-phosphate isomerase ManA; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Bacillus subtilis (strain 168)
PFams: PMI_typeI
315 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 464-483 amino acids (not heteromeric)

O58649 GDP-D-mannose pyrophosphorylase (EC 2.7.7.13; EC 5.3.1.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
O58649 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13); glucose-1-phosphate guanylyltransferase (EC 2.7.7.34); aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.37); mannose-6-phosphate isomerase (EC 5.3.1.8) from Pyrococcus horikoshii
PFams: NTP_transferase, NTP_transf_3, MannoseP_isomer, Cupin_2, AraC_binding
464 amino acids: PaperBLAST, CDD, Compare to cluster

P07874 phosphomannose isomerase (EC 5.3.1.8; EC 2.7.7.13) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
ALGA_PSEAE / P07874 Alginate biosynthesis protein AlgA; EC 5.3.1.8; EC 2.7.7.13 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P07874 mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) from Pseudomonas aeruginosa
PFams: NTP_transferase, NTP_transf_3, MannoseP_isomer, Cupin_2
481 amino acids: PaperBLAST, CDD, Compare to cluster

GI|31296823 alginate biosynthesis protein AlgA; EC 2.7.7.13; EC 5.3.1.8 from Pseudomonas fluorescens
PFams: NTP_transferase, NTP_transf_3, MannoseP_isomer, Cupin_2
483 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 302-333 amino acids (not heteromeric)

PGMI_PYRAE / Q8ZWV0 Bifunctional phosphoglucose/phosphomannose isomerase; Glucose-6-phosphate isomerase; GPI; Mannose-6-phosphate isomerase; Phosphoglucose isomerase; PGI; Phosphomannose isomerase; PMI; EC 5.3.1.9; EC 5.3.1.8 from Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
PFams: bact-PGI_C
302 amino acids: PaperBLAST, CDD, Compare to cluster

PGMI_THEAC / Q9HIC2 Bifunctional phosphoglucose/phosphomannose isomerase; Glucose-6-phosphate isomerase; GPI; Mannose-6-phosphate isomerase; Phosphoglucose isomerase; PGI; Phosphomannose isomerase; PMI; EC 5.3.1.9; EC 5.3.1.8 from Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
PFams: bact-PGI_C
310 amino acids: PaperBLAST, CDD, Compare to cluster

PGMI_AERPE / Q9YE01 Bifunctional phosphoglucose/phosphomannose isomerase; Glucose-6-phosphate isomerase; GPI; Mannose-6-phosphate isomerase; Phosphoglucose isomerase; PGI; Phosphomannose isomerase; PMI; EC 5.3.1.9; EC 5.3.1.8 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
PFams: bact-PGI_C
333 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

Q5SIM4 mannose-6-phosphate isomerase (EC 5.3.1.8) from Thermus thermophilus
254 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q9AGZ4 from Cluster 2, but similarity to seed sequence is below thresholds)

Q976E4 hexose-6-phosphate mutase/isomerase (EC 5.3.1.8; EC 5.3.1.9; EC 5.4.2.10; EC 5.4.2.13) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
PGMUT_SULTO / Q976E4 Phosphoglucosamine/phosphogalactosamine mutase; PGlcNM; EC 5.4.2.10; EC 5.4.2.13 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
PFams: PGM_PMM_I, PGM_PMM_II, PGM_PMM_III, PGM_PMM_IV
455 amino acids: PaperBLAST, CDD

P29954 Mannose-6-phosphate isomerase; EC=5.3.1.8; Phosphohexomutase; AltName: Full=Phosphomannose isomerase; Short=PMI
387 amino acids: PaperBLAST, CDD