Clusters of Characterized Proteins
Clustering the characterized proteins for manX (mannose PTS system, EII-AB component ManX/ManL) in D-mannose catabolism
Or see other characterized proteins similar to manX
Or see all steps for D-mannose catabolism
Or cluster curated proteins matching a keyword
Definition of manX
- Curated sequence CH_088329: PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69. PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191. PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose. mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193). mannose-specific PTS enzyme IIAB component
- Curated sequence D2BKY7: Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine
- Curated sequence E1UCI0: PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN
- Ignore hits to Q5M5W6 when looking for 'other' hits (ManL, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN)
- Ignore hits to Q9S4L5 when looking for 'other' hits (protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191))
- Ignore hits to Q04GK1 when looking for 'other' hits (Phosphotransferase system, mannose/fructose-specific component IIA, component of The hexose (glucose and fructose demonstrated) PTS uptake system)
- Ignore hits to Q2QKM4 when looking for 'other' hits (ManL aka EIIAB, component of Glucose porter, ManLMN)
- Comment: E. coli has manXYZ, where manX has EII-AB, manY has EII-C, and manZ has EII-D. (ManZ is listed twice with slightly different sequence lengths). Similar systems are known in Lactococcus lactis, Listeria monocytogenes, and Streptococcus thermophilus. However, the S. thermophilus system seems not to be active due to a defective IIC domain (PMID:12957931), so those proteins are marked ignore. L. monocytogenes also has a PTS-like regulatory system, mpoABCD, which is not included. (It is reported to act as a glucose transporter, but slowly; not clear if it transports mannose.) There's also a paper about manLMN from Streptococcus salivarius, but I don't think it is actually characterized, so ignore. Closely related to some systems with unclear specificity, ignore those.
Fetched 3 sequences
Running BLASTp
Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences
Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism
Cluster 1 321-329 amino acids (heteromeric)
The first sequence in each cluster is the seed.b1817 mannose-specific PTS enzyme IIAB component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655
P69797 mannose-specific PTS enzyme IIAB component from Escherichia coli (strain K12)
PTNAB_ECOLI / P69797 PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191 from Escherichia coli (strain K12)
TC 4.A.6.1.1 / P69797 PTNA aka MANX aka PTSL aka GPTB aka B1817, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli
RF|NP_416331.1 PTS system mannose-specific EIIAB component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 323 amino acids: PaperBLAST, CDD, Compare to cluster
TC 4.A.6.1.11 / D2BKY7 Mannose-specificPTS system, IIAB component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 329 amino acids: PaperBLAST, CDD, Compare to cluster
TC 4.A.6.1.15 / E1UCI0 PTS system, mannose-specific, IIAB component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
PFams: EIIA-man, PTSIIB_sorb
Heteromeric, 321 amino acids: PaperBLAST, CDD, Compare to cluster