Clusters of Characterized Proteins

Clustering the characterized proteins for mannokinase (D-mannose kinase) in D-mannose catabolism

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Definition of mannokinase

• Curated proteins or TIGRFams with EC 2.7.1.7
• Curated sequence SMc03109: Mannokinase (EC 2.7.1.7)
• Curated sequence MONOMER-19002: N-acetylglucosamine kinase (EC 2.7.1.59)
• UniProt sequence Q5GAN8: SubName: Full=General specificity hexokinase {ECO:0000313|EMBL:AAT74901.1};
• Comment: SMc03109 was annotated as mannokinase but not given this EC number. rokA (MONOMER-19002) and hexA (Q5GAN8) are hexose kinases, including mannose kinases (PMID:PMC545704)

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 5 of these sequences

Found 2 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 455-499 amino acids (not heteromeric)

HXK2_SCHPO / P50521 Hexokinase-2; EC 2.7.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
P50521 hexokinase (EC 2.7.1.1) from Schizosaccharomyces pombe
RF|NP_593865.1 hexokinase 2; EC 2.7.1.1; EC 2.7.1.2; EC 2.7.1.4; EC 2.7.1.7 from Schizosaccharomyces pombe
PFams: Hexokinase_1, Hexokinase_2
455 amino acids: PaperBLAST, CDD, Compare to cluster

HXK1_SCHPO / Q09756 Hexokinase-1; EC 2.7.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Q09756 hexokinase (EC 2.7.1.1) from Schizosaccharomyces pombe
RF|NP_592948.1 hexokinase 1; EC 2.7.1.1; EC 2.7.1.2; EC 2.7.1.4; EC 2.7.1.7 from Schizosaccharomyces pombe
PFams: Hexokinase_1, Hexokinase_2
484 amino acids: PaperBLAST, CDD, Compare to cluster

Q6Q8A5 hexokinase (EC 2.7.1.1; EC 2.7.1.4; EC 2.7.1.7) from Nicotiana tabacum
HXK2_TOBAC / Q6Q8A5 Hexokinase-2, chloroplastic; NtHxK2; EC 2.7.1.1 from Nicotiana tabacum (Common tobacco)
Q6Q8A5 hexokinase (EC 2.7.1.1) from Nicotiana tabacum
PFams: Hexokinase_1, Hexokinase_2
499 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 298-302 amino acids (not heteromeric)

b0394 fructokinase (EC 2.7.1.7; EC 2.7.1.4) from Escherichia coli K-12 substr. MG1655
P23917 fructokinase (EC 2.7.1.7; EC 2.7.1.4) from Escherichia coli (strain K12)
MAK_ECOLI / P23917 Fructokinase; D-fructose kinase; Manno(fructo)kinase; EC 2.7.1.4 from Escherichia coli (strain K12)
PFams: ROK, Glucokinase
302 amino acids: PaperBLAST, CDD, Compare to cluster

SMc03109 Mannokinase (EC 2.7.1.7) from Sinorhizobium meliloti 1021
PFams: ROK
298 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

Q5GAN8 General specificity hexokinase
402 amino acids: PaperBLAST, CDD

Q5GBH5 N-acetylglucosamine kinase (EC 2.7.1.59) from Bacteroides fragilis
PFams: ROK
326 amino acids: PaperBLAST, CDD