Clusters of Characterized Proteins

Clustering the characterized proteins for B12-reactivation-domain (MetH reactivation domain) in L-methionine biosynthesis

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Definition of B12-reactivation-domain

• HMM PF02965
• Ignore hits to items matching EC 2.1.1.13 when looking for 'other' hits
• Predicted: UniProt sequence A0A6I3SQJ4: SubName: Full=Methionine synthase {ECO:0000313|EMBL:MTV50682.1};
• Comment: In E. coli and many other bacteria, the MetH protein includes a reactivation domain (PF02965), but other ATP-dependent (ramA-like) activation proteins are also thought to exist. Ignore MetH proteins, as they often contain the reactivation domain and this creates confusion when checking for reverse hits. In Heliobacterium modesticaldum, the missing reactivation domain is probably provided by H1S01_RS06050 (very similar to A0A6I3SQJ4), which does not hit the HMM but for PF02965 but is found by PFam-N or foldseek, and is usually encoded to next to MetH.

Fetched 1 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 0 of these sequences

Found 0 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Singletons (0/1 heteromeric)

A0A6I3SQJ4 Methionine synthase
259 amino acids: PaperBLAST, CDD