Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for hom (homoserine dehydrogenase) in L-methionine biosynthesis

Or see other characterized proteins similar to hom

Or see all steps for L-methionine biosynthesis

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Definition of hom

Curated proteins or TIGRFams with EC 1.1.1.3
UniProt sequence A0A1L6J6Q3: RecName: Full=Homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579};
UniProt sequence Q8A541_BACTN: SubName: Full=Aspartokinase/homoserine dehydrogenase {ECO:0000313|EMBL:AAO77510.1};
UniProt sequence B8DRS3_DESVM: RecName: Full=Homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579};
UniProt sequence A0A168MV81: RecName: Full=homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013213}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213};
Comment: Ga0059261_2711 (A0A1L6J6Q3) from Sphingomonas koreensis DSMZ 15582 is distant from characterized homoserine dehydrogenases and is confirmed by fitness data. BT2403 from Bacteroides thetaiotaomicron (Q8A541_BACTN) is a fusion of aspartate kinase and homoserine dehydrogenase. The homoserine dehydrogenase portion is somewhat diverged. Its role is confirmed by strong cofitness with threonine synthase (the defined media for B. thetaiotaomicron included methionine). DvMF_1412 from Desulfovibrio vulgaris Miyazaki F (B8DRS3_DESVM) is a somewhat diverged homoserine dehydrogenase; it has auxotrophic phenotypes. A0A168MV81 from Brevundimonas is a somewhat diverged homoserine dehydrogenase (fused to aspartate kinase); it has auxotrophic phenotypes.

Fetched 33 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 31 of these sequences

Found 4 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 304-445 amino acids (not heteromeric)

Q56R01 homoserine dehydrogenase (EC 1.1.1.3) from Streptomyces clavuligerus
PFams: NAD_binding_3, Homoserine_dh, ACT
433 amino acids: PaperBLAST, CDD, Compare to cluster

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus
PFams: NAD_binding_3, Homoserine_dh, ACT
432 amino acids: PaperBLAST, CDD, Compare to cluster

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus methanolicus
PFams: NAD_binding_3, Homoserine_dh
413 amino acids: PaperBLAST, CDD, Compare to cluster

F9VNG5 homoserine dehydrogenase (EC 1.1.1.3) from Sulfurisphaera tokodaii
PFams: NAD_binding_3, Homoserine_dh
304 amino acids: PaperBLAST, CDD, Compare to cluster

DHOM_CORGL / P08499 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
P08499 homoserine dehydrogenase (EC 1.1.1.3) from Corynebacterium glutamicum
PFams: NAD_binding_3, Homoserine_dh, ACT
445 amino acids: PaperBLAST, CDD, Compare to cluster

DHOM_BACSU / P19582 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Bacillus subtilis (strain 168)
P19582 homoserine dehydrogenase (EC 1.1.1.3) from Bacillus subtilis
PFams: NAD_binding_3, Homoserine_dh, ACT
433 amino acids: PaperBLAST, CDD, Compare to cluster

P46806 homoserine dehydrogenase (EC 1.1.1.3) from Mycobacterium leprae
PFams: NAD_binding_3, Homoserine_dh, ACT
441 amino acids: PaperBLAST, CDD, Compare to cluster

DHOM_LACLC / P52985 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Lactococcus lactis subsp. cremoris (Streptococcus cremoris)
PFams: NAD_binding_3, Homoserine_dh
428 amino acids: PaperBLAST, CDD, Compare to cluster

DHOM_NEIG1 / Q5F8J4 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
PFams: NAD_binding_3, Homoserine_dh, ACT
435 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1L6J6Q3 Homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}
430 amino acids: PaperBLAST, CDD, Compare to cluster

B8DRS3_DESVM Homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}
436 amino acids: PaperBLAST, CDD, Compare to cluster

Ga0059261_2711 homoserine dehydrogenase (EC 1.1.1.3) from Sphingomonas koreensis DSMZ 15582
PFams: NAD_binding_3, Homoserine_dh, ACT
430 amino acids: PaperBLAST, CDD, Compare to cluster

DvMF_1412 homoserine dehydrogenase (EC 1.1.1.3) from Desulfovibrio vulgaris Miyazaki F
PFams: NAD_binding_3, Homoserine_dh, ACT
436 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 810-916 amino acids (not heteromeric)

b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655
P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli
PFams: AA_kinase, ACT_7, ACT_7, NAD_binding_3, Homoserine_dh
820 amino acids: PaperBLAST, CDD, Compare to cluster

O63067 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, Compare to cluster

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, Compare to cluster

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
911 amino acids: PaperBLAST, CDD, Compare to cluster

Q8A541_BACTN Aspartokinase/homoserine dehydrogenase
811 amino acids: PaperBLAST, CDD, Compare to cluster

b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655
P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12)
PFams: AA_kinase, NAD_binding_3, Homoserine_dh
810 amino acids: PaperBLAST, CDD, Compare to cluster

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
PFams: AA_kinase, ACT_7, ACT_7, NAD_binding_3, Homoserine_dh
811 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: AA_kinase, ACT_7, NAD_binding_3, Homoserine_dh
815 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
817 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 359-376 amino acids (not heteromeric)

C1G1C3 homoserine dehydrogenase (EC 1.1.1.3) from Paracoccidioides brasiliensis
PFams: NAD_binding_3, Homoserine_dh
372 amino acids: PaperBLAST, CDD, Compare to cluster

C1GTZ6 homoserine dehydrogenase (EC 1.1.1.3) from Paracoccidioides lutzii
PFams: NAD_binding_3, Homoserine_dh
372 amino acids: PaperBLAST, CDD, Compare to cluster

Q3S3F6 homoserine dehydrogenase (EC 1.1.1.3) from Glycine max
PFams: Homoserine_dh
376 amino acids: PaperBLAST, CDD, Compare to cluster

Q5AIA2 homoserine dehydrogenase (EC 1.1.1.3) from Candida albicans
PFams: NAD_binding_3, Homoserine_dh
359 amino acids: PaperBLAST, CDD, Compare to cluster

DHOM_YEAST / P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: NAD_binding_3, Homoserine_dh
359 amino acids: PaperBLAST, CDD, Compare to cluster

DHOM_EMENI / Q5B998 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
CH_122339 homoserine dehydrogenase; EC 1.1.1.3 from Emericella nidulans
PFams: NAD_binding_3, Homoserine_dh
368 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 319-332 amino acids (not heteromeric)

Q5SL04 homoserine dehydrogenase (EC 1.1.1.3) from Thermus thermophilus
PFams: NAD_binding_3, Homoserine_dh
332 amino acids: PaperBLAST, CDD, Compare to cluster

O58802 homoserine dehydrogenase (EC 1.1.1.3) from Pyrococcus horikoshii
PFams: NAD_binding_3, Homoserine_dh
319 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3) from Staphylococcus aureus
PFams: NAD_binding_3, Homoserine_dh
426 amino acids: PaperBLAST, CDD
(similar to BRENDA::D8WXQ2 from Cluster 1, but similarity to seed sequence is below thresholds)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima
PFams: NAD_binding_3, Homoserine_dh, AA_kinase, ACT, ACT_7
739 amino acids: PaperBLAST, CDD

A0A168MV81 homoserine dehydrogenase; EC=1.1.1.3
583 amino acids: PaperBLAST, CDD