Clusters of Characterized Proteins

Clustering the characterized proteins for mesA (Methylcobalamin:homocysteine methyltransferase MesA) in L-methionine biosynthesis

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Definition of mesA

• Curated sequence P55299: Methionine synthase; Homocysteine methyltransferase; Methylcobalamin:homocysteine methyltransferase; EC 2.1.1.-. MtrA-dependent methionine synthase
• Comment: Methanogens have a short homolog of MetE that transfers methyl groups from methylcobalamin (not 5-methyltetrahydrofolates) to homocysteine to form methionine (PMID:10469143). We named this family of "core" methioine synthases MesA and proposed that MtrA (the corrinoid subunit of methyltetrahydromethanopterin:coenzyme M methyltransferase) is the physiological methyl donor (PMC7857596).

Fetched 1 sequences

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Singletons (0/1 heteromeric)

P55299 MtrA-dependent methionine synthase from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)
METE_METTM / P55299 Methionine synthase; Homocysteine methyltransferase; Methylcobalamin:homocysteine methyltransferase; EC 2.1.1.- from Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
PFams: Meth_synt_2, Meth_synt_1
309 amino acids: PaperBLAST, CDD