Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for metY (O-acetylhomoserine sulfhydrylase) in L-methionine biosynthesis

Or see other characterized proteins similar to metY

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metY

Curated proteins or TIGRFams with EC 2.5.1.49
Curated sequence O31631: Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.-
Ignore hits to items matching O-succinylhomoserine sulfhydrylase when looking for 'other' hits
Curated sequence CH_123612: O-acetylhomoserine O-acetylserine sulphydrylase
Curated sequence Q9WZY4: O-acetyl-L-homoserine sulfhydrylase; OAH sulfhydrylase; O-acetylhomoserine thiolase; EC 2.5.1.-
Curated sequence Q5SK88: O-acetyl-L-homoserine sulfhydrylase 1; OAH-sulfhydrylase 1; EC 2.5.1.-
UniProt sequence A0A2T5J8K7: SubName: Full=O-acetylhomoserine (Thiol)-lyase {ECO:0000313|EMBL:PTQ95791.1};
Comment: METI_BACSU (O31631) has activity as OAS but is given a more vague EC number. CH_123612, Q9WZY4, and Q5SK88 are annotated as this but without the EC number. In Mucilaginibacter yixingensis YX-36, C8P68_RS15690 is important for fitness in minimal media; it is usually annotated as O-succinylhomoserine sulfhydrylase, but the acylating enzmye (C8P68_RS13005) is similar to O-acetyltransferases and has the correct functional residues (i.e., similar to H1YC36 in supplementary data set 3 of PMID:28581482); so it must be an o-acetylhomoserine sulfhydrylase.

Fetched 16 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 15 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 373-449 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

L7N4M1 O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) from Mycobacterium tuberculosis
PFams: Cys_Met_Meta_PP
449 amino acids: PaperBLAST, CDD, Compare to cluster

P94890 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) from Leptospira meyeri
METY_LEPME / P94890 O-acetyl-L-homoserine sulfhydrylase; OAH-sulfhydrylase; EC 2.5.1.- from Leptospira meyeri
P94890 O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) from Leptospira meyeri
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1
442 amino acids: PaperBLAST, CDD, Compare to cluster

Q187D4 O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) from Clostridioides difficile
PFams: Cys_Met_Meta_PP
421 amino acids: PaperBLAST, CDD, Compare to cluster

Q7M844 O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) from Wolinella succinogenes
PFams: Cys_Met_Meta_PP, Aminotran_1_2
422 amino acids: PaperBLAST, CDD, Compare to cluster

CYSD_EMENI / P50125 Homocysteine synthase; O-acetylhomoserine sulfhydrylase; OAH SHL; OAH sulfhydrylase; EC 2.5.1.49 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
GI|2605905 O-acetylhomoserine (thiol)-lyase; EC 2.5.1.49 from Emericella nidulans
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Beta_elim_lyase, Aminotran_1_2, Aminotran_5
437 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123612 O-acetylhomoserine O-acetylserine sulphydrylase from Candida albicans
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
440 amino acids: PaperBLAST, CDD, Compare to cluster

CYSD_SCHPO / O13326 Homocysteine synthase; O-acetylhomoserine sulfhydrylase; OAH SHL; OAH sulfhydrylase; EC 2.5.1.49 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
RF|NP_595189.1 homocysteine synthase Met17; EC 2.5.1.49 from Schizosaccharomyces pombe
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
429 amino acids: PaperBLAST, CDD, Compare to cluster

METI_BACSU / O31631 Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.- from Bacillus subtilis (strain 168)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
373 amino acids: PaperBLAST, CDD, Compare to cluster

P06106 Met17 (EC 2.5.1.49) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
CYSD_YEAST / P06106 Homocysteine/cysteine synthase; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylase; EC 2.5.1.47; EC 2.5.1.49 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Beta_elim_lyase, DegT_DnrJ_EryC1, Aminotran_5
444 amino acids: PaperBLAST, CDD, Compare to cluster

METY1_THET8 / Q5SK88 O-acetyl-L-homoserine sulfhydrylase 1; OAH-sulfhydrylase 1; EC 2.5.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
421 amino acids: PaperBLAST, CDD, Compare to cluster

Q79VI4 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
METY_CORGL / Q79VI4 O-acetyl-L-homoserine sulfhydrylase; OAH-sulfhydrylase; EC 2.5.1.49 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1
437 amino acids: PaperBLAST, CDD, Compare to cluster

METY_THEMA / Q9WZY4 O-acetyl-L-homoserine sulfhydrylase; OAH sulfhydrylase; O-acetylhomoserine thiolase; EC 2.5.1.- from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
430 amino acids: PaperBLAST, CDD, Compare to cluster

A0A2T5J8K7 O-acetylhomoserine (Thiol)-lyase
414 amino acids: PaperBLAST, CDD, Compare to cluster

Q2RWB7 O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
PFams: Cys_Met_Meta_PP
438 amino acids: PaperBLAST, CDD, Compare to cluster

Ga0059261_3194 O-acetylhomoserine sulfhydrylase (EC:2.5.1.49) from Sphingomonas koreensis DSMZ 15582
PFams: Cys_Met_Meta_PP, Aminotran_5, Aminotran_1_2
402 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

METW_YEAST / Q12198 Homocysteine/cysteine synthase; Hydrogen sulfide utilizing 1; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylase; EC 2.5.1.47; EC 2.5.1.49 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Cys_Met_Meta_PP
575 amino acids: PaperBLAST, CDD