Clusters of Characterized Proteins

Clustering the characterized proteins for split_metE_1 (vitamin B12-independent methionine synthase, folate-binding component) in L-methionine biosynthesis

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Definition of split_metE_1

• Predicted: UniProt sequence G0EDA1_PYRF1: SubName: Full=Cobalamin-independent synthase MetE domain protein {ECO:0000313|EMBL:AEM39779.1};
• Predicted: UniProt sequence D4GW95: SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (Methionine synthase II) {ECO:0000313|EMBL:ADE02584.1}; EC=2.1.1.14 {ECO:0000313|EMBL:ADE02584.1};
• Comment: In many thermophilic archaea, MetE seems to be split into two pieces (PMC7857596). There is experimental support for a protein complex (PMC2668238), and the two pieces often appear to form an operon, but there is no experimental evidence that they are a methionine synthase. We added the gene from Haloferax volcanii (D4GW95) as it is diverged but is conserved next to a catalytic component with correct functional residues (D4GW90).

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 0 of these sequences

Found 0 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Singletons (0/2 heteromeric)

D4GW95 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (Methionine synthase II); EC=2.1.1.14
336 amino acids: PaperBLAST, CDD

G0EDA1_PYRF1 Cobalamin-independent synthase MetE domain protein
328 amino acids: PaperBLAST, CDD