Clusters of Characterized Proteins

Clustering the characterized proteins for split_metE_2 (vitamin B12-independent methionine synthase, catalytic component) in L-methionine biosynthesis

Or see other characterized proteins similar to split_metE_2

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Definition of split_metE_2

• Predicted: UniProt sequence G0EFB7_PYRF1: RecName: Full=Methionine synthase {ECO:0000256|HAMAP-Rule:MF_00288}; EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_00288}; AltName: Full=Homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00288};
• Predicted: UniProt sequence D4GW90: RecName: Full=Methionine synthase {ECO:0000256|HAMAP-Rule:MF_00288}; EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_00288}; AltName: Full=Homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00288};
• Comment: In many thermophilic archaea, MetE seems to be split into two pieces (see PMC7857596). The catalytic component has the necessary zinc-binding residues (H219, C221, C307) and homocysteine-binding residues (S20, E71, D185). We added the gene from Haloferax volcanii (D4GW90) as it has the correct functional residues and is conserved next to a potential folate-binding component (D4GW90).

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 339-357 amino acids (not heteromeric)

D4GW90 Methionine synthase {ECO:0000256|HAMAP-Rule:MF_00288}; EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_00288}; Homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00288}
357 amino acids: PaperBLAST, CDD, Compare to cluster

G0EFB7_PYRF1 Methionine synthase {ECO:0000256|HAMAP-Rule:MF_00288}; EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_00288}; Homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00288}
339 amino acids: PaperBLAST, CDD, Compare to cluster