Clusters of Characterized Proteins

Clustering the characterized proteins for iolJ (5-dehydro-2-deoxyphosphogluconate aldolase) in myo-inositol catabolism

Or see other characterized proteins similar to iolJ

Or see all steps for myo-inositol catabolism

Or cluster curated proteins matching a keyword

Definition of iolJ

• Curated proteins or TIGRFams with EC 4.1.2.29
• Comment: DUF2090 appears to be a substitute for the aldolase. It is distantly related to aldolases and is found fused to iolC in inositol degradation clusters that lack any apparent iolJ. Fitness data confirms that these fusion proteins are required for myo-inositol utilization (but does not prove that the DUF2090 domain is required). These proteins are included in iolJ via their reannotations.

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 637-681 amino acids (not heteromeric)

BPHYT_RS13910 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Burkholderia phytofirmans PsJN
PFams: PfkB, DUF2090
681 amino acids: PaperBLAST, CDD, Compare to cluster

CCNA_01356 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Caulobacter crescentus NA1000
PFams: PfkB, DUF2090
642 amino acids: PaperBLAST, CDD, Compare to cluster

HSERO_RS12125 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Herbaspirillum seropedicae SmR1
PFams: PfkB, DUF2090
657 amino acids: PaperBLAST, CDD, Compare to cluster

BWI76_RS03085 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Klebsiella michiganensis M5al
PFams: PfkB, DUF2090
637 amino acids: PaperBLAST, CDD, Compare to cluster

SMc01165 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Sinorhizobium meliloti 1021
PFams: PfkB, DUF2090
650 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_11850 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas simiae WCS417
PFams: PfkB, DUF2090
645 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_21335 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2E3
PFams: PfkB, DUF2090
645 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_23160 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2C3
PFams: PfkB, DUF2090
645 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_512 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) from Pseudomonas fluorescens FW300-N2E2
PFams: PfkB, DUF2090
645 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 279-290 amino acids (not heteromeric)

P42420 2-deoxy-5-keto-D-gluconate 6-phosphate aldolase (EC 4.1.2.29) from Bacillus subtilis (strain 168)
IOLJ_BACSU / P42420 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase; DKGP aldolase; EC 4.1.2.29 from Bacillus subtilis (strain 168)
PFams: F_bP_aldolase
290 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_c07220 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29) from Phaeobacter inhibens BS107
PFams: F_bP_aldolase
279 amino acids: PaperBLAST, CDD, Compare to cluster