Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for preph-dehydratase (prephenate dehydratase) in L-phenylalanine biosynthesis

Or see other characterized proteins similar to preph-dehydratase

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Definition of preph-dehydratase

Curated proteins or TIGRFams with EC 4.2.1.51
UniProt sequence Q8A0T5_BACTN: RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Ignore hits to items matching EC 4.2.1.91 when looking for 'other' hits
UniProt sequence D4GRZ0: SubName: Full=Prephenate dehydratase {ECO:0000313|EMBL:ADE02290.1}; EC=4.2.1.51 {ECO:0000313|EMBL:ADE02290.1};
UniProt sequence A0A160HWY7: RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Predicted: UniProt sequence A0A1L8CUL6: RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Comment: prephenate dehydratase and arogenate dehydratase can be difficult to distinguish. BT3936 (Q8A0T5_BACTN) is diverged but has auxotrophic phenotypes (as do homologs Echvi_0123, CA265_RS11630). HVO_0449 (D4GRZ0) is a phenylalanine auxotroph and is probably prephenate dehydratase (PMC4300041). A0A160HWY7 from Brevundimonas is a somewhat diverged prephenate dehydratase; it has auxotrophic phenotypes. The putative prephenate dehydratase from Carboxydothermus pertinax (A0A1L8CUL6) is lacking the regulatory (ACT) domain but has the active site residues and is often encoded near aromatic amino acid synthesis genes (it might be an arogenate dehydratase instead).

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 27 of these sequences

Found 5 clusters of similar sequences. Another 6 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 272-415 amino acids (not heteromeric)

Q6Z3Y3 prephenate dehydratase (EC 4.2.1.51) from Oryza sativa
PFams: PDT
364 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1I9WKA1 prephenate dehydratase (EC 4.2.1.51) from Pinus pinaster
PFams: PDT
415 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1I9WKA6 prephenate dehydratase (EC 4.2.1.51) from Pinus pinaster
PFams: PDT
399 amino acids: PaperBLAST, CDD, Compare to cluster

C7EXK8 prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Escherichia coli
PFams: CM_2, PDT
386 amino acids: PaperBLAST, CDD, Compare to cluster

PHEA_MYCTU / P9WIC3 Prephenate dehydratase; PDT; EC 4.2.1.51 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PHEA_MYCBO / Q7TVJ6 Prephenate dehydratase; PDT; EC 4.2.1.51 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
P9WIC3 prephenate dehydratase (EC 4.2.1.51) from Mycobacterium tuberculosis
PFams: PDT, ACT
321 amino acids: PaperBLAST, CDD, Compare to cluster

Q5NLV8 prephenate dehydratase (EC 4.2.1.51) from Zymomonas mobilis
PFams: PDT
337 amino acids: PaperBLAST, CDD, Compare to cluster

Q8DUV6 prephenate dehydratase (EC 4.2.1.51) from Streptococcus mutans
PFams: PDT
274 amino acids: PaperBLAST, CDD, Compare to cluster

AROD1_ARATH / Q9SA96 Arogenate dehydratase/prephenate dehydratase 1, chloroplastic; AtADT1; AtPDT1; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
Q9SA96 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
392 amino acids: PaperBLAST, CDD, Compare to cluster

AROD2_ARATH / Q9SSE7 Arogenate dehydratase/prephenate dehydratase 2, chloroplastic; AtADT2; AtPDT2; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
Q9SSE7 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
381 amino acids: PaperBLAST, CDD, Compare to cluster

b2599 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli K-12 substr. MG1655
P0A9J8 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli (strain K12)
CMPDT_ECOLI / P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Escherichia coli (strain K12)
CH_024084 P-protein; EC 4.2.1.51; EC 5.4.99.5 from Escherichia coli K12
PFams: CM_2, PDT
386 amino acids: PaperBLAST, CDD, Compare to cluster

AROD2_PETHY / D3U716 Arogenate dehydratase 2; PhADT2; Prephenate dehydratase ADT3; EC 4.2.1.91; EC 4.2.1.51 from Petunia hybrida (Petunia)
D3U716 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida
PFams: PDT
394 amino acids: PaperBLAST, CDD, Compare to cluster

CMPDT_STUST / P27603 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Stutzerimonas stutzeri (Pseudomonas stutzeri)
PFams: CM_2, PDT, ACT
365 amino acids: PaperBLAST, CDD, Compare to cluster

PHEA_METJA / Q58054 Prephenate dehydratase; PDT; MjPDT; EC 4.2.1.51 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: PDT, ACT
272 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_0123 prephenate and/or arogenate dehydratase (EC 4.2.1.51) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: PDT
279 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS11630 prephenate and/or arogenate dehydratase (EC 4.2.1.51) from Pedobacter sp. GW460-11-11-14-LB5
PFams: PDT
277 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 413-439 amino acids (not heteromeric)

AROD3_ARATH / Q9ZUY3 Arogenate dehydratase 3, chloroplastic; AtADT3; Prephenate dehydratase 1; AtPDT1; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
Q9ZUY3 prephenate dehydratase (EC 4.2.1.51); arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
424 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1I9WKA2 prephenate dehydratase (EC 4.2.1.51) from Pinus pinaster
PFams: PDT
439 amino acids: PaperBLAST, CDD, Compare to cluster

AROD6_ARATH / Q9SGD6 Arogenate dehydratase/prephenate dehydratase 6, chloroplastic; AtADT6; AtPDT6; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
Q9SGD6 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
413 amino acids: PaperBLAST, CDD, Compare to cluster

AROD3_PETHY / D3U717 Arogenate dehydratase 3; PhADT3; Prephenate dehydratase ADT3; EC 4.2.1.91; EC 4.2.1.51 from Petunia hybrida (Petunia)
D3U717 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida
PFams: PDT
434 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 272-287 amino acids (not heteromeric)

RF|NP_596269.1 phrenate dehydratase; EC 4.2.1.51 from Schizosaccharomyces pombe
PFams: PDT
287 amino acids: PaperBLAST, CDD, Compare to cluster

PHA2_SCHPO / O14361 Putative prephenate dehydratase; PDT; EC 4.2.1.51 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: PDT
272 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 282-282 amino acids (not heteromeric)

Q8A0T5_BACTN prephenate dehydratase; EC=4.2.1.51
282 amino acids: PaperBLAST, CDD, Compare to cluster

BT3936 prephenate and/or arogenate dehydratase (EC 4.2.1.51) from Bacteroides thetaiotaomicron VPI-5482
PFams: PDT
282 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 591-620 amino acids (not heteromeric)

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Archaeoglobus fulgidus
PFams: PDH_N, PDH_C, CM_2, PDT, ACT
620 amino acids: PaperBLAST, CDD, Compare to cluster

Q74NC4 prephenate dehydratase (EC 4.2.1.51) from Nanoarchaeum equitans
PFams: CM_2, PDT, ACT
591 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/6 heteromeric)

PHEC_PSEAE / Q01269 Cyclohexadienyl dehydratase; EC 4.2.1.51; EC 4.2.1.91 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q01269 arogenate dehydratase (EC 4.2.1.91) from Pseudomonas aeruginosa
PFams: SBP_bac_3
268 amino acids: PaperBLAST, CDD

PHA2_YEAST / P32452 Probable prephenate dehydratase; PDT; Phenylalanine-requiring protein 2; EC 4.2.1.51 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PDT
334 amino acids: PaperBLAST, CDD

CMPDT_BUCAI / P57472 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)
P57472 prephenate dehydratase (EC 4.2.1.51) from Buchnera aphidicola
PFams: CM_2, PDT
385 amino acids: PaperBLAST, CDD
(similar to BRENDA::C7EXK8 from Cluster 1, but similarity to seed sequence is below thresholds)

A0A160HWY7 prephenate dehydratase; EC=4.2.1.51
191 amino acids: PaperBLAST, CDD

A0A1L8CUL6 prephenate dehydratase; EC=4.2.1.51
178 amino acids: PaperBLAST, CDD

D4GRZ0 Prephenate dehydratase; EC=4.2.1.51
268 amino acids: PaperBLAST, CDD
(similar to BRENDA::P9WIC3 from Cluster 1, but similarity to seed sequence is below thresholds)