Clusters of Characterized Proteins

Clustering the characterized proteins for paaG (1,2-epoxyphenylacetyl-CoA isomerase / 2-(oxepinyl)acetyl-CoA isomerase / didehydroadipyl-CoA isomerase ) in phenylacetate catabolism

Or see other characterized proteins similar to paaG

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Definition of paaG

• Curated proteins or TIGRFams with EC 5.3.3.18
• Comment: In MetaCyc, PaaG is described as a 1,2-epoxyphenylacetyl-CoA isomerase, but it is now thought to isomerize 2-(oxepinyl)acetyl-CoA to oxepin-CoA as well as cis-3,4-didehydroadiyplCoA to trans-2,3-didehydroadiypl-CoA (see PMID:31689071).

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 254-262 amino acids (not heteromeric)

PAAG_ECOLI / P77467 1,2-epoxyphenylacetyl-CoA isomerase; EC 5.3.3.18 from Escherichia coli (strain K12)
P77467 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase (EC 5.3.3.18) from Escherichia coli
PFams: ECH_1, ECH_2
262 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SLK3 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase (EC 5.3.3.18) from Thermus thermophilus
PFams: ECH_1, ECH_2
254 amino acids: PaperBLAST, CDD, Compare to cluster