Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for QDPR (6,7-dihydropteridine reductase) in L-phenylalanine catabolism

Or see other characterized proteins similar to QDPR

Or see all steps for L-phenylalanine catabolism

Or cluster curated proteins matching a keyword

Definition of QDPR

Curated proteins or TIGRFams with EC 1.5.1.34
Curated proteins or TIGRFams with EC 1.5.1.50
Ignore hits to P26353 when looking for 'other' hits (Flavohemoprotein; Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD; EC 1.14.12.17)
Ignore hits to P15888 when looking for 'other' hits (nitrobenzene nitroreductase (EC 1.7.1.16))
Ignore hits to Q01234 when looking for 'other' hits (Oxygen-insensitive NAD(P)H nitroreductase; NR; EC 1.-.-.-. nitrobenzene nitroreductase (EC 1.7.1.16))
Comment: In Pseudomonas, the cosubstrate of PAH is (6R)-L-threo-5,6,7,8-tetrahydroneopterin, also known as tetrahydromonapterin; in Chlorobaculum tepidum, it is (6R)-L-threo-5,6,7,8-tetrahydrobiopterin. EC 1.5.1.34 describes tetrahydrobiopterin reductases, while EC 1.5.1.50 describes bacterial dihydromonapterin reductases (folM in E. coli)

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 231-244 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

P09417 Dihydropteridine reductase (EC 1.5.1.34) from Homo sapiens
DHPR_HUMAN / P09417 Dihydropteridine reductase; HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1; EC 1.5.1.34 from Homo sapiens (Human)
P09417 6,7-dihydropteridine reductase (EC 1.5.1.34) from Homo sapiens
PFams: adh_short
244 amino acids: PaperBLAST, CDD, Compare to cluster

Q8MJ30 6,7-dihydropteridine reductase (EC 1.5.1.34) from Sus scrofa
PFams: adh_short
243 amino acids: PaperBLAST, CDD, Compare to cluster

Q8WTJ2 6,7-dihydropteridine reductase (EC 1.5.1.34) from Physarum polycephalum
PFams: adh_short, adh_short_C2
231 amino acids: PaperBLAST, CDD, Compare to cluster

DHPR_DICDI / Q86A17 Dihydropteridine reductase; Quinoid dihydropteridine reductase; EC 1.5.1.34 from Dictyostelium discoideum (Slime mold)
Q86A17 6,7-dihydropteridine reductase (EC 1.5.1.34) from Dictyostelium discoideum
PFams: adh_short, adh_short_C2
231 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli
RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12
PFams: adh_short, adh_short_C2
240 amino acids: PaperBLAST, CDD

b0578 NAD(P)H nitroreductase NfsB (EC 1.5.1.34) from Escherichia coli K-12 substr. MG1655
P38489 NAD(P)H nitroreductase NfsB (EC 1.5.1.34) from Escherichia coli (strain K12)
NFSB_ECOLI / P38489 Oxygen-insensitive NAD(P)H nitroreductase; Dihydropteridine reductase; FMN-dependent nitroreductase; EC 1.-.-.-; EC 1.5.1.34 from Escherichia coli (strain K12)
PDB|1OO5_A oxygen-insensitive NAD(P)H nitroreductase; EC 1.-.-.-; EC 1.5.1.34 from Escherichia coli K12
PFams: Nitroreductase
217 amino acids: PaperBLAST, CDD

b2552 nitric oxide dioxygenase (EC 1.14.12.17; EC 1.5.1.34) from Escherichia coli K-12 substr. MG1655
P24232 nitric oxide dioxygenase (EC 1.14.12.17; EC 1.5.1.34) from Escherichia coli (strain K12)
HMP_ECOLI / P24232 Flavohemoprotein; Flavohemoglobin; HMP; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD; EC 1.14.12.17 from Escherichia coli (strain K12)
GB|AAC75605.1 flavohemoprotein; EC 1.14.12.17 from Escherichia coli K12
PFams: Globin, FAD_binding_6, NAD_binding_1
396 amino acids: PaperBLAST, CDD