Clusters of Characterized Proteins

Clustering the characterized proteins for paaZ2 (3-oxo-5,6-didehydrosuberyl-CoA semialdehyde dehydrogenase) in L-phenylalanine catabolism

Or see other characterized proteins similar to paaZ2

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Definition of paaZ2

• Curated proteins or TIGRFams with EC 1.2.1.91
• UniProt sequence Q5P3J4: SubName: Full=PaaZ protein involved in aerobic phenylacetate metabolism {ECO:0000313|EMBL:CAI08120.1};
• Ignore hits to items matching 1.2.1.77 when looking for 'other' hits
• Comment: PaaZ is a fusion protein of hydrolase and aldehyde dehydrogenase domains. However, a single-domain dehydrogenase has also been characterized (PacL = CAI08120 = Q5P3J4; see PMC3064157). Some of these dehydrogenases are closely related to 3,4-dehydroadipyl-CoA semialdehyde dehydrogenases (EC 1.2.1.77), which perform a similar reaction, so similarity to those are ignored.

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 554-566 amino acids (not heteromeric)

Q5P3J4 PaaZ protein involved in aerobic phenylacetate metabolism
554 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS17340 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (EC 1.2.1.91) from Burkholderia phytofirmans PsJN
PFams: Aldedh
566 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

b1387 oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (EC 3.3.2.12; EC 1.2.1.91; EC 4.2.1.55) from Escherichia coli K-12 substr. MG1655
P77455 oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (EC 3.3.2.12; EC 1.2.1.91; EC 4.2.1.55) from Escherichia coli (strain K12)
PAAZ_ECOLI / P77455 Bifunctional protein PaaZ; EC 3.3.2.12; EC 1.2.1.91 from Escherichia coli (strain K12)
P77455 oxepin-CoA hydrolase (EC 3.3.2.12) from Escherichia coli
PFams: Aldedh, MaoC_dehydratas
681 amino acids: PaperBLAST, CDD