Clusters of Characterized Proteins

Clustering the characterized proteins for lysK ([LysW]-ornithine hydrolase) in L-proline biosynthesis

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Definition of lysK

• Curated proteins or TIGRFams with EC 3.5.1.132
• Predicted: UniProt sequence A9A1L3: RecName: Full=Putative [LysW]-lysine/[LysW]-ornithine hydrolase {ECO:0000256|HAMAP-Rule:MF_01120}; EC=3.5.1.130 {ECO:0000256|HAMAP-Rule:MF_01120}; EC=3.5.1.132 {ECO:0000256|HAMAP-Rule:MF_01120};
• Comment: TK0274 from Thermococcus kodakarensis (Q5JFW4) is bifunctional, for lysine and ornithine synthesis (PMC5076833). NMAR_RS06940 (A9A1L3) is probably bifunctional for [LysW]-ornithine and [LysW]-lysined hydrolase; this would explain how ornithine is formed in Nitrosopumilus maritimus, and it is similar to [LysW]-lysine hydrolyze Q8VUS5, which is reported to hydrolyze acetyllysine or acetylornithine in vitro.

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 346-375 amino acids (not heteromeric)

A9A1L3 Putative [LysW]-lysine/[LysW]-ornithine hydrolase {ECO:0000256|HAMAP-Rule:MF_01120}; EC=3.5.1.130 {ECO:0000256|HAMAP-Rule:MF_01120}; EC=3.5.1.132 {ECO:0000256|HAMAP-Rule:MF_01120}
375 amino acids: PaperBLAST, CDD, Compare to cluster

Q4JAP7 [amino group carrier protein]-lysine/ornithine hydrolase (EC 3.5.1.130; EC 3.5.1.132) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
PFams: Peptidase_M20, M20_dimer
346 amino acids: PaperBLAST, CDD, Compare to cluster