Clusters of Characterized Proteins

Clustering the characterized proteins for lysZ ([LysW]-glutamate kinase) in L-proline biosynthesis

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Definition of lysZ

• Curated proteins or TIGRFams with EC 2.7.2.19
• UniProt sequence Q5JFW2: RecName: Full=Putative [LysW]-aminoadipate/[LysW]-glutamate kinase {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.17 {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.19 {ECO:0000256|HAMAP-Rule:MF_02082};
• Predicted: UniProt sequence D4GYN9: RecName: Full=Putative [LysW]-aminoadipate/[LysW]-glutamate kinase {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.17 {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.19 {ECO:0000256|HAMAP-Rule:MF_02082};
• Comment: TK0276 from Thermococcus kodakarensis (Q5JFW2) is bifunctional, for lysine and ornithine synthesis (PMC5076833). In Haloferax volcanii, the putative [LysW]-glutamate kinase (HVO_RS04915, D4GYN9) is in a conserved operon with LysW and with other arginine synthesis genes; this protein is more similar to a characterized [LysW]-2-aminoadipate 6-kinase, but haloarchaea do not use the aminoadipate pathway (PMC93780, PMC8305020).

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 251-327 amino acids (not heteromeric)

Q4JAQ2 [LysW}-glutamate/[LysW]-aminoadipate kinase (EC 2.7.2.17; EC 2.7.2.19) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
LYSZ_SULAC / Q4JAQ2 [LysW]-aminoadipate/[LysW]-glutamate kinase; EC 2.7.2.17; EC 2.7.2.19 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Q4JAQ2 [amino group carrier protein]-L-2-aminoadipate 6-kinase (EC 2.7.2.17) from Sulfolobus acidocaldarius
PFams: AA_kinase
261 amino acids: PaperBLAST, CDD, Compare to cluster

D4GYN9 Putative [LysW]-aminoadipate/[LysW]-glutamate kinase {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.17 {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.19 {ECO:0000256|HAMAP-Rule:MF_02082}
327 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JFW2 Putative [LysW]-aminoadipate/[LysW]-glutamate kinase {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.17 {ECO:0000256|HAMAP-Rule:MF_02082}; EC=2.7.2.19 {ECO:0000256|HAMAP-Rule:MF_02082}
251 amino acids: PaperBLAST, CDD, Compare to cluster