Clusters of Characterized Proteins

Clustering the characterized proteins for SLC6A7 (proline:Na+ symporter) in L-proline catabolism

Or see other characterized proteins similar to SLC6A7

Or see all steps for L-proline catabolism

Or cluster curated proteins matching a keyword

Definition of SLC6A7

• Curated sequence CH_091144: sodium-dependent proline transporter. Proline:Na+ symporter
• Curated sequence Q64093: Sodium- and chloride-dependent transporter XTRP3; Sodium/imino-acid transporter 1; Solute carrier family 6 member 20; Transporter rB21A. sodium- and chloride-dependent transporter XTRP3. Na+/Amino acid transporter 1, SIT1/IMINO (SLC6A20). Transports imino acids such as proline (Km=0.2 mM), pipecolate, and N-methylated amino acids such as MeAIB and sarcosine (Na+-dependent, Cl--stimulated, pH-independent, voltage-dependent) (Li+, but not H+ can substitute for Na+) (Takanaga et al., 2005). It is a 2Na+/1Cl--proline cotransporter
• Curated sequence P48065: Betaine/GABA:Na+ symporter, BGT1. (Substrates include: betaine, GABA, diaminobutyrate, β-alanine, proline, quinidine, dimethylglycine, glycine, and sarcosine with decreasing affinity in that order)
• Curated sequence Q99884: Sodium-dependent proline transporter (Solute carrier family 6 member 7)

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 614-637 amino acids (not heteromeric)

TC 2.A.22.2.1 / P28573 Proline:Na+ symporter from Rattus norvegicus (Rat)
RF|NP_446448.2 sodium-dependent proline transporter from Rattus norvegicus
PFams: SNF
637 amino acids: PaperBLAST, CDD, Compare to cluster

S6A20_RAT / Q64093 Sodium- and chloride-dependent transporter XTRP3; Sodium/imino-acid transporter 1; Solute carrier family 6 member 20; Transporter rB21A from Rattus norvegicus (Rat)
TC 2.A.22.6.1 / Q64093 Na+/Amino acid transporter 1, SIT1/IMINO (SLC6A20). Transports imino acids such as proline (Km=0.2 mM), pipecolate, and N-methylated amino acids such as MeAIB and sarcosine (Na+-dependent, Cl--stimulated, pH-independent, voltage-dependent) (Li+, but not H+ can substitute for Na+) (Takanaga et al., 2005). It is a 2Na+/1Cl--proline cotransporter from Rattus norvegicus (Rat)
RF|NP_579830.1 sodium- and chloride-dependent transporter XTRP3 from Rattus norvegicus
PFams: SNF
616 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.22.3.1 / P48065 Betaine/GABA:Na+ symporter, BGT1. (Substrates include: betaine, GABA, diaminobutyrate, β-alanine, proline, quinidine, dimethylglycine, glycine, and sarcosine with decreasing affinity in that order) from Homo sapiens (Human)
PFams: SNF
614 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.22.2.11 / Q99884 Sodium-dependent proline transporter (Solute carrier family 6 member 7) from Homo sapiens
PFams: SNF
636 amino acids: PaperBLAST, CDD, Compare to cluster