Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for gabD (succinate semialdehyde dehydrogenase) in putrescine catabolism

Or see other characterized proteins similar to gabD

Or see all steps for putrescine catabolism

Or cluster curated proteins matching a keyword

Definition of gabD

Curated proteins or TIGRFams with EC 1.2.1.79
Curated proteins or TIGRFams with EC 1.2.1.24
Curated proteins or TIGRFams with EC 1.2.1.16
Ignore hits to Q8BUF0 when looking for 'other' hits (succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24))
Ignore hits to items matching 1.2.1.20 when looking for 'other' hits
Ignore hits to items matching 1.2.1.3 when looking for 'other' hits
Ignore hits to Q9I6M5 when looking for 'other' hits (Glutarate-semialdehyde dehydrogenase; EC 1.2.1.-. glutarate semialdehyde dehydrogenase)
Comment: This may be either NADH or NADPH dependent, forming succinate in either case. Close homologs in Pseudomonas or Klebsiella are annotated as glutarate-semialdehyde dehydrogenases (1.2.1.20) or aldehyde dehydrogenases (1.2.1.3); Q9I6M5 is annotated as glutarate-semialdehyde dehydrogenase but with no EC number. Q8BUF0 appears to be misannotated in BRENDA.

Fetched 37 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 34 of these sequences

Found 1 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 450-547 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

B0JFD4 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Lucilia cuprina
PFams: Aldedh
507 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0J9X1M8 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) from Streptococcus pyogenes
PFams: Aldedh
465 amino acids: PaperBLAST, CDD, Compare to cluster

B1XMM6 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) from Synechococcus sp.
PFams: Aldedh
454 amino acids: PaperBLAST, CDD, Compare to cluster

b1300 γ-glutamyl-γ-aminobutyraldehyde dehydrogenase (EC 1.2.1.19; EC 1.2.1.24; EC 1.2.1.99) from Escherichia coli K-12 substr. MG1655
P23883 γ-glutamyl-γ-aminobutyraldehyde dehydrogenase (EC 1.2.1.19; EC 1.2.1.24; EC 1.2.1.99) from Escherichia coli (strain K12)
PUUC_ECOLI / P23883 NADP/NAD-dependent aldehyde dehydrogenase PuuC; ALDH; 3-hydroxypropionaldehyde dehydrogenase; Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Gamma-Glu-gamma-aminobutyraldehyde dehydrogenase; EC 1.2.1.5 from Escherichia coli (strain K12)
P23883 4-(gamma-glutamylamino)butanal dehydrogenase (EC 1.2.1.99) from Escherichia coli
PFams: Aldedh
495 amino acids: PaperBLAST, CDD, Compare to cluster

b2661 succinate-semialdehyde dehydrogenase (NADP⁺) GabD (EC 1.2.1.79) from Escherichia coli K-12 substr. MG1655
P25526 succinate-semialdehyde dehydrogenase (NADP⁺) GabD (EC 1.2.1.79) from Escherichia coli (strain K12)
GABD_ECOLI / P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12)
P25526 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) from Escherichia coli K-12
GB|AAC75708.1 succinate-semialdehyde dehydrogenase [NAD(P)+]; EC 1.2.1.16 from Escherichia coli K12
PFams: Aldedh
482 amino acids: PaperBLAST, CDD, Compare to cluster

P51649 Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) from Homo sapiens
SSDH_HUMAN / P51649 Succinate-semialdehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; EC 1.2.1.24 from Homo sapiens (Human)
P51649 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Homo sapiens
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q0K2K1 NAD(P)+-dependent succinate semialdehyde dehydrogenase monomer (EC 1.2.1.16) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
Q0K2K1 succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) from Cupriavidus necator
PFams: Aldedh
483 amino acids: PaperBLAST, CDD, Compare to cluster

Q3MSM3 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Hylobates lar
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q3MSM4 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Pan paniscus
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q6A2H0 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Pan troglodytes
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q6A2H1 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Gorilla gorilla
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q6A2H2 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Pongo pygmaeus pygmaeus
PFams: Aldedh
535 amino acids: PaperBLAST, CDD, Compare to cluster

Q8ZPI3 succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: Aldedh
462 amino acids: PaperBLAST, CDD, Compare to cluster

Q976X5 succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Sulfurisphaera tokodaii
PFams: Aldedh
468 amino acids: PaperBLAST, CDD, Compare to cluster

Q97XA5 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79); glyceraldehyde-3-phosphate dehydrogenase (NADP+) (EC 1.2.1.9) from Saccharolobus solfataricus
PFams: Aldedh
470 amino acids: PaperBLAST, CDD, Compare to cluster

Q97XS9 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24); glyceraldehyde-3-phosphate dehydrogenase (NADP+) (EC 1.2.1.9) from Saccharolobus solfataricus
PFams: Aldedh
470 amino acids: PaperBLAST, CDD, Compare to cluster

Q9VBP6 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Drosophila melanogaster
PFams: Aldedh, DUF1487
509 amino acids: PaperBLAST, CDD, Compare to cluster

b1525 succinate semialdehyde dehydrogenase (NAD(P)⁺) Sad (EC 1.2.1.24) from Escherichia coli K-12 substr. MG1655
P76149 succinate semialdehyde dehydrogenase (NAD(P)⁺) Sad (EC 1.2.1.24) from Escherichia coli (strain K12)
SAD_ECOLI / P76149 Succinate semialdehyde dehydrogenase [NAD(P)+] Sad; SSADH; SSDH; EC 1.2.1.16 from Escherichia coli (strain K12)
RF|NP_416042 aldehyde dehydrogenase-like protein yneI from Escherichia coli K12
PFams: Aldedh
462 amino acids: PaperBLAST, CDD, Compare to cluster

GABD_BACSU / P94428 Succinate-semialdehyde dehydrogenase [NADP(+)]; SSDH; EC 1.2.1.79 from Bacillus subtilis (strain 168)
P94428 succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) from Bacillus subtilis
PFams: Aldedh
462 amino acids: PaperBLAST, CDD, Compare to cluster

GABD2_MYCTU / P9WNX7 Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2; SSADH 2; SSDH 2; EC 1.2.1.79 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Aldedh
518 amino acids: PaperBLAST, CDD, Compare to cluster

P9WNX9 NADP-dependent succinate-semialdehyde dehydrogenase (EC 1.2.1.79) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
GABD1_MYCTU / P9WNX9 Succinate-semialdehyde dehydrogenase [NADP(+)] 1; SSADH 1; SSDH 1; EC 1.2.1.79 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WNX9 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) from Mycobacterium tuberculosis
PFams: Aldedh
457 amino acids: PaperBLAST, CDD, Compare to cluster

KGSD1_AZOBR / Q1JUP4 Alpha-ketoglutaric semialdehyde dehydrogenase 1; alphaKGSA dehydrogenase 1; 2,5-dioxovalerate dehydrogenase 1; 2-oxoglutarate semialdehyde dehydrogenase 1; KGSADH-I; Succinate-semialdehyde dehydrogenase [NAD(+)]; SSDH; EC 1.2.1.26; EC 1.2.1.24 from Azospirillum brasilense
Q1JUP4 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24); 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) from Azospirillum brasilense
PFams: Aldedh
481 amino acids: PaperBLAST, CDD, Compare to cluster

TGNE_ACIAD / Q6F9G0 Succinate semialdehyde dehydrogenase; SSA dehydrogenase; EC 1.2.1.24 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
PFams: Aldedh
483 amino acids: PaperBLAST, CDD, Compare to cluster

SSDH_PAENI / Q8GAI8 Succinate-semialdehyde dehydrogenase; SsaDH; EC 1.2.1.16 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans)
PFams: Aldedh
450 amino acids: PaperBLAST, CDD, Compare to cluster

Q8GAK7 succinate-semialdehyde dehydrogenase (NADP⁺) monomer (EC 1.2.1.79) from Paenarthrobacter nicotinovorans
ALDH_PAENI / Q8GAK7 Aldehyde dehydrogenase; NAD/NADP-dependent aldehyde dehydrogenase; EC 1.2.1.3; EC 1.2.1.4 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans)
PFams: Aldedh
458 amino acids: PaperBLAST, CDD, Compare to cluster

SSDH_ARATH / Q9SAK4 Succinate-semialdehyde dehydrogenase, mitochondrial; At-SSADH1; Aldehyde dehydrogenase family 5 member F1; NAD(+)-dependent succinic semialdehyde dehydrogenase; Protein ENLARGED FIL EXPRESSING DOMAIN 1; EC 1.2.1.24 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aldedh
528 amino acids: PaperBLAST, CDD, Compare to cluster

SSDH1_SCHPO / Q9US47 Putative succinate-semialdehyde dehydrogenase C1002.12c [NADP(+)]; SSDH; EC 1.2.1.16 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Aldedh
547 amino acids: PaperBLAST, CDD, Compare to cluster

SSDH2_SCHPO / Q9UTM8 Putative succinate-semialdehyde dehydrogenase C139.05 [NADP(+)]; SSDH; EC 1.2.1.16 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Aldedh
493 amino acids: PaperBLAST, CDD, Compare to cluster

Q9RBF6 NADP-dependent succinate semialdehyde dehydrogenase (EC 1.2.1.79) from Cupriavidus necator
Q9RBF6 succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) from Cupriavidus necator
PFams: Aldedh
483 amino acids: PaperBLAST, CDD, Compare to cluster

Q4KKA2 NAD(P)-dependent succinate-semialdehyde dehydrogenase (EC 1.2.1.16) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
PFams: Aldedh
480 amino acids: PaperBLAST, CDD, Compare to cluster

A0A222FYW4 succinate-semialdehyde dehydrogenase (NAD⁺) (EC 1.2.1.24) from Alicycliphilus sp.
PFams: Aldedh
480 amino acids: PaperBLAST, CDD, Compare to cluster

P38067 NAD(P)-dependent succinate semialdehyde dehydrogenase (EC 1.2.1.16) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: Aldedh
497 amino acids: PaperBLAST, CDD, Compare to cluster

SO1275 succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] from Shewanella oneidensis MR-1
PFams: Aldedh
482 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_11505 succinate-semialdehyde dehydrogenase (EC 1.2.1.16) from Pseudomonas fluorescens FW300-N2E3
PFams: Aldedh
480 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

A2R4V5 succinate-semialdehyde dehydrogenase (NAD+) (EC 1.2.1.24) from Aspergillus niger
PFams: Aldedh
650 amino acids: PaperBLAST, CDD

P38947 succinate semialdehyde dehydrogenase subunit (EC 1.2.1.76) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
GB|AAA92347.1 succinate-semialdehyde dehydrogenase [NAD(P)+]; EC 1.2.1.16 from Clostridium kluyveri DSM 555
PFams: Aldedh
453 amino acids: PaperBLAST, CDD

B1Q3F6 NAD-dependent succinate semialdehyde dehydrogenase (EC 1.2.1.24) from Solanum lycopersicum
PFams: NAD_binding_2, ApbA, F420_oxidored, NAD_binding_11
287 amino acids: PaperBLAST, CDD