Clusters of Characterized Proteins

Clustering the characterized proteins for SLC5A8 (sodium-coupled pyruvate transporter) in pyruvate catabolism

Or see other characterized proteins similar to SLC5A8

Or see all steps for pyruvate catabolism

Or cluster curated proteins matching a keyword

Definition of SLC5A8

• Curated sequence Q3ZMH1: Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; zSMCTe; Sodium solute symporter family 5 member 8 protein; Solute carrier family 5 member 8. sodium-coupled monocarboxylate transporter 1. The high affinity (Km (lactate) = 0.2mM) electrogenic Na+ monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTe
• Curated sequence Q7T384: Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; zSMCTn; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12; zSLC5A12. sodium-coupled monocarboxylate transporter 2. The low affinity (Km (lactate) = 2mM) electroneutral Na+:monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTn
• Curated sequence Q8N695: Sodium-coupled monocarboxylate transporter 1; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8. Na+-dependent short chain fatty acid transporter SLC5A8 (tumor suppressor gene product, down-regulated in colon cancer) (substrates: lactate, pyruvate, acetate, propionate, butyrate (Km ≈1 mM)) [propionate:Na+ = 1:3] (Miyauchi et al., 2004). Pyroglutamate (5-oxoproline) is also transported in a Na+- coupled mechanism (Miyauchi et al., 2010). SMCT1 and SMCT2 may transport monocarboxylate drugs (e.g. nicotinate and its derivatives) across the intestinal brush boarder membrane

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 610-623 amino acids (not heteromeric)

SC5A8_DANRE / Q3ZMH1 Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; zSMCTe; Sodium solute symporter family 5 member 8 protein; Solute carrier family 5 member 8 from Danio rerio (Zebrafish) (Brachydanio rerio)
TC 2.A.21.5.5 / Q3ZMH1 The high affinity (Km (lactate) = 0.2mM) electrogenic Na+ monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTe from Danio rerio (Zebrafish) (Brachydanio rerio)
RF|NP_001030141.1 sodium-coupled monocarboxylate transporter 1 from Danio rerio
PFams: SSF
610 amino acids: PaperBLAST, CDD, Compare to cluster

SC5AC_DANRE / Q7T384 Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; zSMCTn; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12; zSLC5A12 from Danio rerio (Zebrafish) (Brachydanio rerio)
TC 2.A.21.5.4 / Q7T384 The low affinity (Km (lactate) = 2mM) electroneutral Na+:monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTn from Danio rerio (Zebrafish) (Brachydanio rerio)
GB|AAW55812.1 sodium-coupled monocarboxylate transporter 2 from Danio rerio
PFams: SSF
623 amino acids: PaperBLAST, CDD, Compare to cluster

SC5A8_HUMAN / Q8N695 Sodium-coupled monocarboxylate transporter 1; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8 from Homo sapiens (Human)
TC 2.A.21.5.3 / Q8N695 Na+-dependent short chain fatty acid transporter SLC5A8 (tumor suppressor gene product, down-regulated in colon cancer) (substrates: lactate, pyruvate, acetate, propionate, butyrate (Km ≈1 mM)) [propionate:Na+ = 1:3] (Miyauchi et al., 2004). Pyroglutamate (5-oxoproline) is also transported in a Na+- coupled mechanism (Miyauchi et al., 2010). SMCT1 and SMCT2 may transport monocarboxylate drugs (e.g. nicotinate and its derivatives) across the intestinal brush boarder membrane
PFams: SSF
610 amino acids: PaperBLAST, CDD, Compare to cluster