Clusters of Characterized Proteins

Clustering the characterized proteins for dctP (pyruvate TRAP transporter, substrate-binding component) in pyruvate catabolism

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Definition of dctP

• Curated sequence Q8YSQ6: Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P. Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids
• Curated sequence D5ALT6: TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM])
• Ignore hits to Q3J1R2 when looking for 'other' hits (Alpha-keto acid-binding periplasmic protein TakP; Extracytoplasmic solute receptor protein TakP; TRAP transporter alpha-keto acid-binding subunit P; TRAP-T family sorbitol/mannitol transporter, periplasmic binding protein, SmoM)
• UniProt sequence Q48AL6: SubName: Full=Extracellular solute-binding protein, family 7 {ECO:0000313|EMBL:AAZ28655.1};
• Comment: DctP from Nostoc, Rhodobacter; associated with dctQ and dctM. Similar to TakP (Q3J1R2), which is misannotated and not characterized. The related protein Q48AL6 = CPS_0129 was shown to bind calcium-pyruvate (PMC4310620).

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 362-365 amino acids (2/3 heteromeric)

TMBP_NOSS1 / Q8YSQ6 Monocarboxylate 2-oxoacid-binding periplasmic protein all3028; Extracellular solute-binding protein; Extracytoplasmic solute receptor protein all3028; TRAP transporter monocarboxylate 2-oxoacid-binding subunit P from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
TC 2.A.56.3.3 / Q8YSQ6 Extracellular solute-binding protein, component of The 2-oxo monocarboxylate transporter (Pernil et al., 2010). Transports pyruvate which is inhibited by various 2-ketoacids from Nostoc sp. (strain PCC 7120 / UTEX 2576)
PFams: DctP
Heteromeric, 364 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.56.3.4 / D5ALT6 TRAP dicarboxylate transporter, DctP-2 subunit, component of The 2-ketomonocarboxylate transporter (presented in order of affinity - 2-oxovalerate [highest affinity, KD=0.1 μM], 2-oxoisovalerate, 2-oxobutyrate, 2-oxoisocaproate, 2-oxo-3-methylvalerate, pyruvate [lowest affinity, KD=3 μM]) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
PFams: DctP
Heteromeric, 365 amino acids: PaperBLAST, CDD, Compare to cluster

Q48AL6 Extracellular solute-binding protein, family 7
362 amino acids: PaperBLAST, CDD, Compare to cluster